Open Access

Nature Structural and Molecular Biology, volume 21, issue 2, pages 198-206

Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre

Hacisuleyman Ezgi ^{1, 2, 3}

Goff Loyal A ^{1, 2, 4}

Trapnell Cole ^{1, 2}

Williams Adam ⁵

Henao-Mejia Jorge ⁵

Sun Lei ⁶

Mcclanahan Patrick ⁷

Hendrickson David G. ^{1, 2}

Sauvageau Martin ^{1, 2}

Kelley David R. ^{1, 2}

Morse Michael ¹

Engreitz Jesse ¹

Lander Eric S ¹

Guttman Mitch ⁸

Lodish Harvey F. ^{6, 9, 10}

Flavell Richard ^{5, 11}

Raj Arjun ⁷

Rinn John L. ^{1, 2, 12}

Hide authors affiliations Show authors affiliations: 12 affiliations

Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, USA |

Department of Stem cell and Regenerative Biology, Harvard University, Cambridge, USA |

Department of Molecular and Cellular biology, Harvard University, Cambridge, USA |

⁴

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, USA |

⁵

Department of Immunobiology, Yale University School of Medicine, New Haven, USA |

⁶

Whitehead Institute for Biomedical Research, Cambridge, USA |

⁷

Department of Bioengineering, University of Pennsylvania, Philadelphia, USA |

⁸

Department of Biology, California Institute of Technology, Pasadena, USA |

⁹

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA |

¹⁰

Department of Biology, Massachusetts Institute of Technology, Cambridge, USA |

¹¹

Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, USA |

¹²

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, USA |

Publication type: Journal Article

Publication date: 2014-01-26

Springer Nature

Journal: Nature Structural and Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor: 16.8

ISSN: 15459993, 15459985

DOI: 10.1038/nsmb.2764

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PubMed ID: 24463464

Molecular Biology

Structural Biology

Abstract

RNA, including long noncoding RNA (lncRNA), is known to be an abundant and important structural component of the nuclear matrix. However, the molecular identities, functional roles and localization dynamics of lncRNAs that influence nuclear architecture remain poorly understood. Here, we describe one lncRNA, Firre, that interacts with the nuclear-matrix factor hnRNPU through a 156-bp repeating sequence and localizes across an ~5-Mb domain on the X chromosome. We further observed Firre localization across five distinct trans-chromosomal loci, which reside in spatial proximity to the Firre genomic locus on the X chromosome. Both genetic deletion of the Firre locus and knockdown of hnRNPU resulted in loss of colocalization of these trans-chromosomal interacting loci. Thus, our data suggest a model in which lncRNAs such as Firre can interface with and modulate nuclear architecture across chromosomes.

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Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 5, 0.94% Proceedings of the National Academy of Sciences of the United States of America 5 publications, 0.94%
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Citations by publishers

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Elsevier	Elsevier, 113, 21.28% Elsevier 113 publications, 21.28%
Springer Nature	Springer Nature, 107, 20.15% Springer Nature 107 publications, 20.15%
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Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 5, 0.94% Proceedings of the National Academy of Sciences (PNAS) 5 publications, 0.94%
Rockefeller University Press	Rockefeller University Press, 5, 0.94% Rockefeller University Press 5 publications, 0.94%
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SAGE	SAGE, 2, 0.38% SAGE 2 publications, 0.38%
The American Association of Immunologists	The American Association of Immunologists, 1, 0.19% The American Association of Immunologists 1 publication, 0.19%
	20 40 60 80 100 120

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Hacisuleyman E. et al. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre // Nature Structural and Molecular Biology. 2014. Vol. 21. No. 2. pp. 198-206.

GOST all authors (up to 50) Copy

Hacisuleyman E., Goff L. A., Trapnell C., Williams A., Henao-Mejia J., Sun L., Mcclanahan P., Hendrickson D. G., Sauvageau M., Kelley D. R., Morse M., Engreitz J., Lander E. S., Guttman M., Lodish H. F., Flavell R., Raj A., Rinn J. L. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre // Nature Structural and Molecular Biology. 2014. Vol. 21. No. 2. pp. 198-206.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/nsmb.2764

UR - https://doi.org/10.1038%2Fnsmb.2764

TI - Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre

T2 - Nature Structural and Molecular Biology

AU - Hacisuleyman, Ezgi

AU - Goff, Loyal A

AU - Trapnell, Cole

AU - Williams, Adam

AU - Henao-Mejia, Jorge

AU - Sun, Lei

AU - Mcclanahan, Patrick

AU - Hendrickson, David G.

AU - Sauvageau, Martin

AU - Kelley, David R.

AU - Morse, Michael

AU - Engreitz, Jesse

AU - Lander, Eric S

AU - Guttman, Mitch

AU - Lodish, Harvey F.

AU - Flavell, Richard

AU - Raj, Arjun

AU - Rinn, John L.

PY - 2014

DA - 2014/01/26 00:00:00

PB - Springer Nature

SP - 198-206

IS - 2

VL - 21

PMID - 24463464

SN - 1545-9993

SN - 1545-9985

ER -

BibTex |

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BibTex Copy

@article{2014_Hacisuleyman,

author = {Ezgi Hacisuleyman and Loyal A Goff and Cole Trapnell and Adam Williams and Jorge Henao-Mejia and Lei Sun and Patrick Mcclanahan and David G. Hendrickson and Martin Sauvageau and David R. Kelley and Michael Morse and Jesse Engreitz and Eric S Lander and Mitch Guttman and Harvey F. Lodish and Richard Flavell and Arjun Raj and John L. Rinn},

title = {Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre},

journal = {Nature Structural and Molecular Biology},

year = {2014},

volume = {21},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1038%2Fnsmb.2764},

number = {2},

pages = {198--206},

doi = {10.1038/nsmb.2764}

}

MLA

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MLA Copy

Hacisuleyman, Ezgi, et al. “Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.” Nature Structural and Molecular Biology, vol. 21, no. 2, Jan. 2014, pp. 198-206. https://doi.org/10.1038%2Fnsmb.2764.

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Publisher

Springer Nature

Journal

Nature Structural and Molecular Biology

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Quartile WOS

Impact factor

16.8

ISSN

15459993 (Print)
15459985 (Electronic)