Open Access

Nature Structural and Molecular Biology, volume 21, issue 9, pages 787-793

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome

Polikanov Yury S. ^{1, 2}

Steitz Thomas A. ^{1, 2, 3}

Innis C Axel ^{1, 4}

Hide authors affiliations Show authors affiliations: 4 affiliations

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, USA |

Howard Hughes Medical Institute, Yale University, New Haven, USA |

Department of Chemistry, Yale University, New Haven, USA |

⁴

Present address: Institut Européen de Chimie et Biologie, Université de Bordeaux, Pessac, France and Institut National de la Santé et de la Recherche Médicale (U869), Bordeaux, France., |

Publication type: Journal Article

Publication date: 2014-08-17

Springer Nature

Journal: Nature Structural and Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor: 16.8

ISSN: 15459993, 15459985

DOI: 10.1038/nsmb.2871

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PubMed ID: 25132179

Molecular Biology

Structural Biology

Abstract

During peptide-bond formation on the ribosome, the α-amine of an aminoacyl-tRNA attacks the ester carbonyl carbon of a peptidyl-tRNA to yield a peptide lengthened by one amino acid. Although the ribosome's contribution to catalysis is predominantly entropic, the lack of high-resolution structural data for the complete active site in complex with full-length ligands has made it difficult to assess how the ribosome might influence the pathway of the reaction. Here, we present crystal structures of preattack and postcatalysis complexes of the Thermus thermophilus 70S ribosome at ~2.6-Å resolution. These structures reveal a network of hydrogen bonds along which proton transfer could take place to ensure the concerted, rate-limiting formation of a tetrahedral intermediate. We propose that, unlike earlier models, the ribosome and the A-site tRNA facilitate the deprotonation of the nucleophile through the activation of a water molecule.

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Polikanov Y. S. et al. A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome // Nature Structural and Molecular Biology. 2014. Vol. 21. No. 9. pp. 787-793.

GOST all authors (up to 50) Copy

Polikanov Y. S., Steitz T. A., Innis C. A. A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome // Nature Structural and Molecular Biology. 2014. Vol. 21. No. 9. pp. 787-793.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/nsmb.2871

UR - https://doi.org/10.1038%2Fnsmb.2871

TI - A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome

T2 - Nature Structural and Molecular Biology

AU - Polikanov, Yury S.

AU - Steitz, Thomas A.

AU - Innis, C Axel

PY - 2014

DA - 2014/08/17 00:00:00

PB - Springer Nature

SP - 787-793

IS - 9

VL - 21

PMID - 25132179

SN - 1545-9993

SN - 1545-9985

ER -

BibTex |

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BibTex Copy

@article{2014_Polikanov,

author = {Yury S. Polikanov and Thomas A. Steitz and C Axel Innis},

title = {A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome},

journal = {Nature Structural and Molecular Biology},

year = {2014},

volume = {21},

publisher = {Springer Nature},

month = {aug},

url = {https://doi.org/10.1038%2Fnsmb.2871},

number = {9},

pages = {787--793},

doi = {10.1038/nsmb.2871}

}

MLA

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MLA Copy

Polikanov, Yury S., et al. “A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.” Nature Structural and Molecular Biology, vol. 21, no. 9, Aug. 2014, pp. 787-793. https://doi.org/10.1038%2Fnsmb.2871.

Found error?

Publisher

Springer Nature

Journal

Nature Structural and Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor

16.8

ISSN

15459993 (Print)
15459985 (Electronic)