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Nature Structural and Molecular Biology, volume 22, issue 4, pages 342-344

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

Polikanov Yury S. ^{1, 2}

Melnikov Sergey ¹

Söll Dieter ^{1, 3}

Steitz Thomas A. ^{1, 2, 3}

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Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, USA |

Howard Hughes Medical Institute at Yale University, New Haven, USA |

Department of Chemistry, Yale University, New Haven, USA |

Publication type: Journal Article

Publication date: 2015-03-16

Springer Nature

Journal: Nature Structural and Molecular Biology

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Quartile WOS

Impact factor: 16.8

ISSN: 15459993, 15459985

DOI: 10.1038/nsmb.2992

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PubMed ID: 25775268

Molecular Biology

Structural Biology

Abstract

We report crystal structures of the Thermus thermophilus ribosome at 2.3- to 2.5-Å resolution, which have enabled modeling of rRNA modifications. The structures reveal contacts of modified nucleotides with mRNA and tRNAs or protein pY, and contacts within the ribosome interior stabilizing the functional fold of rRNA. Our work provides a resource to explore the roles of rRNA modifications and yields a more comprehensive atomic model of a bacterial ribosome.

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Nucleic Acids Research	Nucleic Acids Research, 23, 10.85% Nucleic Acids Research 23 publications, 10.85%
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Scientific Reports	Scientific Reports, 4, 1.89% Scientific Reports 4 publications, 1.89%
Nature Structural and Molecular Biology	Nature Structural and Molecular Biology, 4, 1.89% Nature Structural and Molecular Biology 4 publications, 1.89%
Journal of Biological Chemistry	Journal of Biological Chemistry, 4, 1.89% Journal of Biological Chemistry 4 publications, 1.89%
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Nature	Nature, 3, 1.42% Nature 3 publications, 1.42%
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Frontiers in Microbiology	Frontiers in Microbiology, 2, 0.94% Frontiers in Microbiology 2 publications, 0.94%
Trends in Biochemical Sciences	Trends in Biochemical Sciences, 2, 0.94% Trends in Biochemical Sciences 2 publications, 0.94%
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Citations by publishers

	5 10 15 20 25 30 35
Springer Nature	Springer Nature, 31, 14.62% Springer Nature 31 publications, 14.62%
Oxford University Press	Oxford University Press, 28, 13.21% Oxford University Press 28 publications, 13.21%
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American Chemical Society (ACS)	American Chemical Society (ACS), 7, 3.3% American Chemical Society (ACS) 7 publications, 3.3%
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EMBO press	EMBO press, 4, 1.89% EMBO press 4 publications, 1.89%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 3, 1.42% Public Library of Science (PLoS) 3 publications, 1.42%
Walter de Gruyter	Walter de Gruyter, 3, 1.42% Walter de Gruyter 3 publications, 1.42%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 3, 1.42% American Association for the Advancement of Science (AAAS) 3 publications, 1.42%
American Society for Microbiology	American Society for Microbiology, 2, 0.94% American Society for Microbiology 2 publications, 0.94%
eLife Sciences Publications	eLife Sciences Publications, 2, 0.94% eLife Sciences Publications 2 publications, 0.94%
The Company of Biologists	The Company of Biologists, 1, 0.47% The Company of Biologists 1 publication, 0.47%
Portland Press	Portland Press, 1, 0.47% Portland Press 1 publication, 0.47%
PeerJ	PeerJ, 1, 0.47% PeerJ 1 publication, 0.47%
Biophysical Society	Biophysical Society, 1, 0.47% Biophysical Society 1 publication, 0.47%
IEEE	IEEE, 1, 0.47% IEEE 1 publication, 0.47%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 1, 0.47% American Association for Cancer Research (AACR) 1 publication, 0.47%
	5 10 15 20 25 30 35

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Polikanov Y. S. et al. Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly // Nature Structural and Molecular Biology. 2015. Vol. 22. No. 4. pp. 342-344.

GOST all authors (up to 50) Copy

Polikanov Y. S., Melnikov S., Söll D., Steitz T. A. Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly // Nature Structural and Molecular Biology. 2015. Vol. 22. No. 4. pp. 342-344.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/nsmb.2992

UR - https://doi.org/10.1038%2Fnsmb.2992

TI - Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

T2 - Nature Structural and Molecular Biology

AU - Polikanov, Yury S.

AU - Melnikov, Sergey

AU - Söll, Dieter

AU - Steitz, Thomas A.

PY - 2015

DA - 2015/03/16 00:00:00

PB - Springer Nature

SP - 342-344

IS - 4

VL - 22

PMID - 25775268

SN - 1545-9993

SN - 1545-9985

ER -

BibTex |

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BibTex Copy

@article{2015_Polikanov,

author = {Yury S. Polikanov and Sergey Melnikov and Dieter Söll and Thomas A. Steitz},

title = {Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly},

journal = {Nature Structural and Molecular Biology},

year = {2015},

volume = {22},

publisher = {Springer Nature},

month = {mar},

url = {https://doi.org/10.1038%2Fnsmb.2992},

number = {4},

pages = {342--344},

doi = {10.1038/nsmb.2992}

}

MLA

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MLA Copy

Polikanov, Yury S., et al. “Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.” Nature Structural and Molecular Biology, vol. 22, no. 4, Mar. 2015, pp. 342-344. https://doi.org/10.1038%2Fnsmb.2992.

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Publisher

Springer Nature

Journal

Nature Structural and Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor

16.8

ISSN

15459993 (Print)
15459985 (Electronic)