Nature Structural and Molecular Biology, volume 12, issue 12, pages 1145-1149

Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome

Myasnikov Alexander G. ¹

Marzi Stefano ^{1, 2}

Simonetti Angelita ¹

Giuliodori Anna Maria ³

Gualerzi Claudio O. ³

Yusupova Gulnara ¹

Yusupov Marat ^{1, 2}

Klaholz Bruno P. ¹

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Department of Structural Biology and Genomics, Institute of Genetics and Molecular and Cellular Biology, Centre National de la Recherche Scientifique (CNRS)/Institut National de la Santé et de la Recherche Médicale (INSERM)/Université Louis Pasteur, B.P. 10142, Illkirch, France |

Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France |

Department of Biology MCA, Laboratory of Genetics, University of Camerino, Camerino (MC), Italy |

Publication type: Journal Article

Publication date: 2005-11-13

Springer Nature

Journal: Nature Structural and Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor: 16.8

ISSN: 15459993, 15459985

DOI: 10.1038/nsmb1012

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Molecular Biology

Structural Biology

Abstract

Initiation of protein synthesis is a universally conserved event that requires initiation factors IF1, IF2 and IF3 in prokaryotes. IF2 is a GTPase essential for binding initiator transfer RNA to the 30S ribosomal subunit and recruiting the 50S subunit into the 70S initiation complex. We present two cryo-EM structures of the assembled 70S initiation complex comprising mRNA, fMet-tRNAfMet and IF2 with either a non-hydrolyzable GTP analog or GDP. Transition from the GTP-bound to the GDP-bound state involves substantial conformational changes of IF2 and of the entire ribosome. In the GTP analog–bound state, IF2 interacts mostly with the 30S subunit and extends to the initiator tRNA in the peptidyl (P) site, whereas in the GDP-bound state IF2 steps back and adopts a 'ready-to-leave' conformation. Our data also provide insights into the molecular mechanism guiding release of IF1 and IF3.

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	2 4 6 8 10 12
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Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 9, 7.26% Proceedings of the National Academy of Sciences of the United States of America 9 publications, 7.26%
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Biochemistry	Biochemistry, 5, 4.03% Biochemistry 5 publications, 4.03%
Nucleic Acids Research	Nucleic Acids Research, 5, 4.03% Nucleic Acids Research 5 publications, 4.03%
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Acta Crystallographica Section F:Structural Biology Communications	Acta Crystallographica Section F:Structural Biology Communications, 1, 0.81% Acta Crystallographica Section F:Structural Biology Communications 1 publication, 0.81%
Acta Crystallographica Section F Structural Biology and Crystallization Communications	Acta Crystallographica Section F Structural Biology and Crystallization Communications, 1, 0.81% Acta Crystallographica Section F Structural Biology and Crystallization Communications 1 publication, 0.81%
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Scientific Reports	Scientific Reports, 1, 0.81% Scientific Reports 1 publication, 0.81%
Biology Direct	Biology Direct, 1, 0.81% Biology Direct 1 publication, 0.81%
Nature Structural and Molecular Biology	Nature Structural and Molecular Biology, 1, 0.81% Nature Structural and Molecular Biology 1 publication, 0.81%
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	2 4 6 8 10 12

Citations by publishers

	5 10 15 20 25 30 35
Elsevier	Elsevier, 33, 26.61% Elsevier 33 publications, 26.61%
Springer Nature	Springer Nature, 12, 9.68% Springer Nature 12 publications, 9.68%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 9, 7.26% Proceedings of the National Academy of Sciences (PNAS) 9 publications, 7.26%
Wiley	Wiley, 7, 5.65% Wiley 7 publications, 5.65%
American Chemical Society (ACS)	American Chemical Society (ACS), 6, 4.84% American Chemical Society (ACS) 6 publications, 4.84%
EMBO press	EMBO press, 5, 4.03% EMBO press 5 publications, 4.03%
Oxford University Press	Oxford University Press, 5, 4.03% Oxford University Press 5 publications, 4.03%
International Union of Crystallography (IUCr)	International Union of Crystallography (IUCr), 4, 3.23% International Union of Crystallography (IUCr) 4 publications, 3.23%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 2.42% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 2.42%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 3, 2.42% American Society for Biochemistry and Molecular Biology 3 publications, 2.42%
Taylor & Francis	Taylor & Francis, 3, 2.42% Taylor & Francis 3 publications, 2.42%
American Society for Microbiology	American Society for Microbiology, 3, 2.42% American Society for Microbiology 3 publications, 2.42%
Annual Reviews	Annual Reviews, 3, 2.42% Annual Reviews 3 publications, 2.42%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 3, 2.42% Cold Spring Harbor Laboratory 3 publications, 2.42%
Pleiades Publishing	Pleiades Publishing, 2, 1.61% Pleiades Publishing 2 publications, 1.61%
Editions E D K	Editions E D K, 2, 1.61% Editions E D K 2 publications, 1.61%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 1.61% Public Library of Science (PLoS) 2 publications, 1.61%
Scientific Research Publishing	Scientific Research Publishing, 1, 0.81% Scientific Research Publishing 1 publication, 0.81%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 0.81% American Association for the Advancement of Science (AAAS) 1 publication, 0.81%
	5 10 15 20 25 30 35

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Myasnikov A. G. et al. Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome // Nature Structural and Molecular Biology. 2005. Vol. 12. No. 12. pp. 1145-1149.

GOST all authors (up to 50) Copy

Myasnikov A. G., Marzi S., Simonetti A., Giuliodori A. M., Gualerzi C. O., Yusupova G., Yusupov M., Klaholz B. P. Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome // Nature Structural and Molecular Biology. 2005. Vol. 12. No. 12. pp. 1145-1149.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/nsmb1012

UR - https://doi.org/10.1038%2Fnsmb1012

TI - Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome

T2 - Nature Structural and Molecular Biology

AU - Myasnikov, Alexander G.

AU - Marzi, Stefano

AU - Simonetti, Angelita

AU - Giuliodori, Anna Maria

AU - Gualerzi, Claudio O.

AU - Yusupova, Gulnara

AU - Yusupov, Marat

AU - Klaholz, Bruno P.

PY - 2005

DA - 2005/11/13 00:00:00

PB - Springer Nature

SP - 1145-1149

IS - 12

VL - 12

SN - 1545-9993

SN - 1545-9985

ER -

BibTex |

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BibTex Copy

@article{2005_Myasnikov,

author = {Alexander G. Myasnikov and Stefano Marzi and Angelita Simonetti and Anna Maria Giuliodori and Claudio O. Gualerzi and Gulnara Yusupova and Marat Yusupov and Bruno P. Klaholz},

title = {Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome},

journal = {Nature Structural and Molecular Biology},

year = {2005},

volume = {12},

publisher = {Springer Nature},

month = {nov},

url = {https://doi.org/10.1038%2Fnsmb1012},

number = {12},

pages = {1145--1149},

doi = {10.1038/nsmb1012}

}

MLA

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MLA Copy

Myasnikov, Alexander G., et al. “Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome.” Nature Structural and Molecular Biology, vol. 12, no. 12, Nov. 2005, pp. 1145-1149. https://doi.org/10.1038%2Fnsmb1012.

Found error?

Publisher

Springer Nature

Journal

Nature Structural and Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor

16.8

ISSN

15459993 (Print)
15459985 (Electronic)