Nature Structural and Molecular Biology, volume 15, issue 1, pages 26-33
TER1, the RNA subunit of fission yeast telomerase
1
Stowers Institute for Medical Research, Kansas City, USA
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2
Present address: Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA.,
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3
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, USA
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Publication type: Journal Article
Publication date: 2007-12-23
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16.8
ISSN: 15459993, 15459985
DOI:
10.1038/nsmb1343
Molecular Biology
Structural Biology
Abstract
Telomerase is the ribonucleoprotein complex that adds telomeric repeats to the ends of chromosomes. Its protein subunit TERT is highly conserved among eukaryotes, whereas the RNA subunit varies greatly in size and sequence, hindering the identification of telomerase RNAs in some important model organisms. Here we report the identification and functional characterization of TER1, the telomerase RNA component from fission yeast Schizosaccharomyces pombe. Deletion of ter1+ caused progressive shortening of telomeres and cellular senescence followed by chromosome circularization. Interactions between Est1 and Trt1, the two known protein components of fission yeast telomerase, were dependent on TER1, supporting its role as a scaffold for the assembly of protein subunits. Using a series of template mutations, we show that translocation or dissociation site variability and template-primer slippage account for the sequence heterogeneity of fission yeast telomeres.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Leonardi J. et al. TER1, the RNA subunit of fission yeast telomerase // Nature Structural and Molecular Biology. 2007. Vol. 15. No. 1. pp. 26-33.
GOST all authors (up to 50)
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Leonardi J., Box J. A., Bunch J. T., Baumann P. TER1, the RNA subunit of fission yeast telomerase // Nature Structural and Molecular Biology. 2007. Vol. 15. No. 1. pp. 26-33.
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TY - JOUR
DO - 10.1038/nsmb1343
UR - https://doi.org/10.1038%2Fnsmb1343
TI - TER1, the RNA subunit of fission yeast telomerase
T2 - Nature Structural and Molecular Biology
AU - Leonardi, Jessica
AU - Box, Jessica A
AU - Bunch, Jeremy T
AU - Baumann, Peter
PY - 2007
DA - 2007/12/23 00:00:00
PB - Springer Nature
SP - 26-33
IS - 1
VL - 15
SN - 1545-9993
SN - 1545-9985
ER -
Cite this
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@article{2007_Leonardi,
author = {Jessica Leonardi and Jessica A Box and Jeremy T Bunch and Peter Baumann},
title = {TER1, the RNA subunit of fission yeast telomerase},
journal = {Nature Structural and Molecular Biology},
year = {2007},
volume = {15},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1038%2Fnsmb1343},
number = {1},
pages = {26--33},
doi = {10.1038/nsmb1343}
}
Cite this
MLA
Copy
Leonardi, Jessica, et al. “TER1, the RNA subunit of fission yeast telomerase.” Nature Structural and Molecular Biology, vol. 15, no. 1, Dec. 2007, pp. 26-33. https://doi.org/10.1038%2Fnsmb1343.