Journal of Antibiotics, volume 72, issue 3, pages 164-168

Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876

Yang Zhijun 1
Shao Lei 1
Wang Meixia 2
Rao Min 3
Ge Mei 3
Xu Yixin 1
Publication typeJournal Article
Publication date2018-12-18
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor3.3
ISSN00218820, 18811469
Drug Discovery
Pharmacology
Abstract
Two novel quinomycins I (1) and J (3) were discovered by UPLC-MS, then the two novel compounds and five known quinomycins A(2), B(4), E(5), C(6) and monosulfoxide quinomycin (7) were isolated from the culture broth of Streptomyces sp. HCCB11876. The structures of these compounds were elucidated through MS and NMR spectroscopic analysis. Compounds 1–7 showed significant antibacterial and cytotoxic activities. The structure-activity relationship indicated that sulfoxide group in N-methylcysteine of quinomycins (1, 3 and 7) would significantly decrease the antibacterial and cytotoxic activities. Moreover, the antibacterial and cytotoxic activities were decreased with the increase of carbon chain in amino-acid residues.

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GOST |
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GOST Copy
Yang Z. et al. Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876 // Journal of Antibiotics. 2018. Vol. 72. No. 3. pp. 164-168.
GOST all authors (up to 50) Copy
Yang Z., Shao L., Wang M., Rao M., Ge M., Xu Y. Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876 // Journal of Antibiotics. 2018. Vol. 72. No. 3. pp. 164-168.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1038/s41429-018-0132-1
UR - https://doi.org/10.1038%2Fs41429-018-0132-1
TI - Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876
T2 - Journal of Antibiotics
AU - Yang, Zhijun
AU - Shao, Lei
AU - Wang, Meixia
AU - Rao, Min
AU - Ge, Mei
AU - Xu, Yixin
PY - 2018
DA - 2018/12/18 00:00:00
PB - Springer Nature
SP - 164-168
IS - 3
VL - 72
SN - 0021-8820
SN - 1881-1469
ER -
BibTex |
Cite this
BibTex Copy
@article{2018_Yang
author = {Zhijun Yang and Lei Shao and Meixia Wang and Min Rao and Mei Ge and Yixin Xu},
title = {Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876},
journal = {Journal of Antibiotics},
year = {2018},
volume = {72},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1038%2Fs41429-018-0132-1},
number = {3},
pages = {164--168},
doi = {10.1038/s41429-018-0132-1}
}
MLA
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MLA Copy
Yang, Zhijun, et al. “Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876.” Journal of Antibiotics, vol. 72, no. 3, Dec. 2018, pp. 164-168. https://doi.org/10.1038%2Fs41429-018-0132-1.
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