Journal of Antibiotics, volume 72, issue 3, pages 164-168
Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876
3
Shanghai Laiyi Center for Biopharmaceutical R&D, Shanghai, China
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Publication type: Journal Article
Publication date: 2018-12-18
Journal:
Journal of Antibiotics
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.3
ISSN: 00218820, 18811469
Drug Discovery
Pharmacology
Abstract
Two novel quinomycins I (1) and J (3) were discovered by UPLC-MS, then the two novel compounds and five known quinomycins A(2), B(4), E(5), C(6) and monosulfoxide quinomycin (7) were isolated from the culture broth of Streptomyces sp. HCCB11876. The structures of these compounds were elucidated through MS and NMR spectroscopic analysis. Compounds 1–7 showed significant antibacterial and cytotoxic activities. The structure-activity relationship indicated that sulfoxide group in N-methylcysteine of quinomycins (1, 3 and 7) would significantly decrease the antibacterial and cytotoxic activities. Moreover, the antibacterial and cytotoxic activities were decreased with the increase of carbon chain in amino-acid residues.
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Journal of Medicinal Chemistry
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1 publication, 14.29%
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Natural Product Reports
1 publication, 14.29%
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Molecules
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Molecules
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1
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Citations by publishers
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3
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Multidisciplinary Digital Publishing Institute (MDPI)
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3 publications, 42.86%
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Elsevier
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Elsevier
1 publication, 14.29%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 14.29%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 14.29%
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1
2
3
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- We do not take into account publications that without a DOI.
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Yang Z. et al. Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876 // Journal of Antibiotics. 2018. Vol. 72. No. 3. pp. 164-168.
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Yang Z., Shao L., Wang M., Rao M., Ge M., Xu Y. Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876 // Journal of Antibiotics. 2018. Vol. 72. No. 3. pp. 164-168.
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TY - JOUR
DO - 10.1038/s41429-018-0132-1
UR - https://doi.org/10.1038%2Fs41429-018-0132-1
TI - Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876
T2 - Journal of Antibiotics
AU - Yang, Zhijun
AU - Shao, Lei
AU - Wang, Meixia
AU - Rao, Min
AU - Ge, Mei
AU - Xu, Yixin
PY - 2018
DA - 2018/12/18 00:00:00
PB - Springer Nature
SP - 164-168
IS - 3
VL - 72
SN - 0021-8820
SN - 1881-1469
ER -
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@article{2018_Yang
author = {Zhijun Yang and Lei Shao and Meixia Wang and Min Rao and Mei Ge and Yixin Xu},
title = {Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876},
journal = {Journal of Antibiotics},
year = {2018},
volume = {72},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1038%2Fs41429-018-0132-1},
number = {3},
pages = {164--168},
doi = {10.1038/s41429-018-0132-1}
}
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MLA
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Yang, Zhijun, et al. “Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876.” Journal of Antibiotics, vol. 72, no. 3, Dec. 2018, pp. 164-168. https://doi.org/10.1038%2Fs41429-018-0132-1.