Nature Reviews Molecular Cell Biology, volume 20, issue 2, pages 116-131
Ribosome assembly coming into focus
1
Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, USA
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Publication type: Journal Article
Publication date: 2018-11-22
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 112.7
ISSN: 14710072, 14710080
PubMed ID:
30467428
Molecular Biology
Cell Biology
Abstract
In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have identified most of the factors that participate in this complex pathway and have generated models for the mechanisms driving the assembly. More recently, the publication of numerous cryo-electron microscopy structures of yeast ribosome assembly intermediates has provided near-atomic resolution snapshots of ribosome precursor particles. Satisfyingly, these structural data support the genetic and biochemical models and provide additional mechanistic insight into ribosome assembly. In this Review, we discuss the mechanisms of assembly of the yeast small ribosomal subunit and large ribosomal subunit in the nucleolus, nucleus and cytoplasm. Particular emphasis is placed on concepts such as the mechanisms of RNA compaction, the functions of molecular switches and molecular mimicry, the irreversibility of assembly checkpoints and the roles of structural and functional proofreading of pre-ribosomal particles. Our understanding of eukaryotic ribosome assembly has been boosted by recently published cryo-electron microscopy structures of yeast ribosome assembly intermediates. These studies highlight the roles of RNA compaction, checkpoints and proofreading mechanisms of pre-ribosomal particles in the nucleolus, nucleus and cytoplasm.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
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Klinge S., Woolford J. Ribosome assembly coming into focus // Nature Reviews Molecular Cell Biology. 2018. Vol. 20. No. 2. pp. 116-131.
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Klinge S., Woolford J. Ribosome assembly coming into focus // Nature Reviews Molecular Cell Biology. 2018. Vol. 20. No. 2. pp. 116-131.
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TY - JOUR
DO - 10.1038/s41580-018-0078-y
UR - https://doi.org/10.1038%2Fs41580-018-0078-y
TI - Ribosome assembly coming into focus
T2 - Nature Reviews Molecular Cell Biology
AU - Klinge, Sebastian
AU - Woolford, John
PY - 2018
DA - 2018/11/22 00:00:00
PB - Springer Nature
SP - 116-131
IS - 2
VL - 20
PMID - 30467428
SN - 1471-0072
SN - 1471-0080
ER -
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@article{2018_Klinge,
author = {Sebastian Klinge and John Woolford},
title = {Ribosome assembly coming into focus},
journal = {Nature Reviews Molecular Cell Biology},
year = {2018},
volume = {20},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1038%2Fs41580-018-0078-y},
number = {2},
pages = {116--131},
doi = {10.1038/s41580-018-0078-y}
}
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MLA
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Klinge, Sebastian, and John Woolford. “Ribosome assembly coming into focus.” Nature Reviews Molecular Cell Biology, vol. 20, no. 2, Nov. 2018, pp. 116-131. https://doi.org/10.1038%2Fs41580-018-0078-y.