Nature Reviews Molecular Cell Biology, volume 21, issue 7, pages 384-397
Regulation of human telomerase in homeostasis and disease
1
Stanford Cancer Institute, Stanford University School of Medicine, Stanford, USA
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2
Department of Medicine, Stanford University School of Medicine, Stanford, USA
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3
Department of Biochemistry, Stanford University School of Medicine, Stanford, USA
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Publication type: Journal Article
Publication date: 2020-04-02
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 112.7
ISSN: 14710072, 14710080
PubMed ID:
32242127
Molecular Biology
Cell Biology
Abstract
Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR), which serves as a template for the addition of telomeric repeats to chromosome ends. Telomerase expression is restricted in humans to certain cell types, and telomerase levels are tightly controlled in normal conditions. Increased levels of telomerase are found in the vast majority of human cancers, and we have recently begun to understand the mechanisms by which cancer cells increase telomerase activity. Conversely, germline mutations in telomerase-relevant genes that decrease telomerase function cause a range of genetic disorders, including dyskeratosis congenita, idiopathic pulmonary fibrosis and bone marrow failure. In this Review, we discuss the transcriptional regulation of human TERT, hTR processing, assembly of the telomerase complex, the cellular localization of telomerase and its recruitment to telomeres, and the regulation of telomerase activity. We also discuss the disease relevance of each of these steps of telomerase biogenesis. Telomere length is maintained by telomerase, which comprises a reverse transcriptase and a template RNA. Telomerase activity is disrupted in several genetic disorders, but is commonly increased in cancer. Recent studies have uncovered many regulatory mechanisms of telomerase and how telomerase upregulation in cancer is achieved.
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Roake C. M. et al. Regulation of human telomerase in homeostasis and disease // Nature Reviews Molecular Cell Biology. 2020. Vol. 21. No. 7. pp. 384-397.
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Roake C. M., Artandi S. E. Regulation of human telomerase in homeostasis and disease // Nature Reviews Molecular Cell Biology. 2020. Vol. 21. No. 7. pp. 384-397.
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TY - JOUR
DO - 10.1038/s41580-020-0234-z
UR - https://doi.org/10.1038%2Fs41580-020-0234-z
TI - Regulation of human telomerase in homeostasis and disease
T2 - Nature Reviews Molecular Cell Biology
AU - Roake, Caitlin M
AU - Artandi, Steven E.
PY - 2020
DA - 2020/04/02 00:00:00
PB - Springer Nature
SP - 384-397
IS - 7
VL - 21
PMID - 32242127
SN - 1471-0072
SN - 1471-0080
ER -
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@article{2020_Roake,
author = {Caitlin M Roake and Steven E. Artandi},
title = {Regulation of human telomerase in homeostasis and disease},
journal = {Nature Reviews Molecular Cell Biology},
year = {2020},
volume = {21},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1038%2Fs41580-020-0234-z},
number = {7},
pages = {384--397},
doi = {10.1038/s41580-020-0234-z}
}
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MLA
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Roake, Caitlin M., et al. “Regulation of human telomerase in homeostasis and disease.” Nature Reviews Molecular Cell Biology, vol. 21, no. 7, Apr. 2020, pp. 384-397. https://doi.org/10.1038%2Fs41580-020-0234-z.