Open Access
Scientific Reports, volume 8, issue 1, publication number 16428
Dissection of differential vanadate sensitivity in two Ogataea species links protein glycosylation and phosphate transport regulation
Karginov Azamat V
1
,
Fokina Anastasia V
1
,
Kang Hyun-Ah
2
,
Kalebina Tatyana S.
3
,
Sabirzyanova Tatyana A
3
,
Ter-Avanesyan Michael D.
1
,
1
2
Department of Life science, Chung-Ang University, Seoul, Republic of Korea
|
Publication type: Journal Article
Publication date: 2018-11-06
PubMed ID:
30401924
Multidisciplinary
Abstract
The closely related yeasts Ogataea polymorpha and O. parapolymorpha differ drastically from each other by sensitivity to the toxic phosphate analog vanadate. Search for genes underlying this difference revealed two genes, one designated as ABV1 (Alcian Blue staining, Vanadate resistance), which encodes a homologue of Saccharomyces cerevisiae Mnn4 responsible for attachment of mannosylphosphate to glycoside chains of secretory proteins, and the other designated as its S. cerevisiae homologue PHO87, encoding the plasma membrane low affinity phosphate sensor/transporter. The effect of Pho87 on vanadate resistance was bidirectional, since it decreased the resistance on phosphate-depleted medium, but was required for pronounced protection against vanadate by external phosphate. This highlights the dual function of this protein as a low affinity phosphate transporter and an external phosphate sensor. Involvement of Pho87 in phosphate sensing was confirmed by its effects on regulation of the promoter of the PHO84 gene, encoding a high affinity phosphate transporter. The effect of Abv1 was also complex, since it influenced Pho87 level and enhanced repression of the PHO84 promoter via a Pho87-independent pathway. Role of the identified genes in the difference in vanadate resistance between O. polymorpha and O. parapolymorpha is discussed.
Citations by journals
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1
2
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Scientific Reports
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Scientific Reports
2 publications, 33.33%
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Folia Microbiologica
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Folia Microbiologica
1 publication, 16.67%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 16.67%
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Prion
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Prion
1 publication, 16.67%
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American Journal of Physiology - Lung Cellular and Molecular Physiology
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American Journal of Physiology - Lung Cellular and Molecular Physiology
1 publication, 16.67%
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1
2
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Citations by publishers
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1
2
3
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Springer Nature
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Springer Nature
3 publications, 50%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 16.67%
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Taylor & Francis
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Taylor & Francis
1 publication, 16.67%
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American Physiological Society
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American Physiological Society
1 publication, 16.67%
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1
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3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Karginov A. V. et al. Dissection of differential vanadate sensitivity in two Ogataea species links protein glycosylation and phosphate transport regulation // Scientific Reports. 2018. Vol. 8. No. 1. 16428
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Karginov A. V., Fokina A. V., Kang H., Kalebina T. S., Sabirzyanova T. A., Ter-Avanesyan M. D., Agaphonov M. O. Dissection of differential vanadate sensitivity in two Ogataea species links protein glycosylation and phosphate transport regulation // Scientific Reports. 2018. Vol. 8. No. 1. 16428
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TY - JOUR
DO - 10.1038/s41598-018-34888-5
UR - https://doi.org/10.1038%2Fs41598-018-34888-5
TI - Dissection of differential vanadate sensitivity in two Ogataea species links protein glycosylation and phosphate transport regulation
T2 - Scientific Reports
AU - Karginov, Azamat V
AU - Fokina, Anastasia V
AU - Kang, Hyun-Ah
AU - Kalebina, Tatyana S.
AU - Sabirzyanova, Tatyana A
AU - Ter-Avanesyan, Michael D.
AU - Agaphonov, M. O.
PY - 2018
DA - 2018/11/06 00:00:00
PB - Springer Nature
IS - 1
VL - 8
PMID - 30401924
SN - 2045-2322
ER -
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@article{2018_Karginov,
author = {Azamat V Karginov and Anastasia V Fokina and Hyun-Ah Kang and Tatyana S. Kalebina and Tatyana A Sabirzyanova and Michael D. Ter-Avanesyan and M. O. Agaphonov},
title = {Dissection of differential vanadate sensitivity in two Ogataea species links protein glycosylation and phosphate transport regulation},
journal = {Scientific Reports},
year = {2018},
volume = {8},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1038%2Fs41598-018-34888-5},
number = {1},
doi = {10.1038/s41598-018-34888-5}
}