Open Access
Scientific Reports, volume 11, issue 1, publication number 13774
New insights into the microscopic interactions associated with the physical mechanism of action of highly diluted biologics
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Lehrstuhl für BioMolekulare Optik, Ludwig-Maximilians-Universität, Munich, Germany
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Publication type: Journal Article
Publication date: 2021-07-02
PubMed ID:
34215838
Multidisciplinary
Abstract
In this investigation, we report the effect on the microscopic dynamics and interactions of the cytokine interferon gamma (IFN-γ) and antibodies to IFN-γ (anti-IFN-γ) and to the interferon gamma receptor 1 (anti-IFNGR1) prepared in exceptionally dilute solutions of initial proteins. Using both THz spectroscopy and molecular dynamics simulations we have uncovered that the high dilution method of sample preparation results in the reorganization of the sample surface residue dynamics at the solvent–protein interface that leads to both structural and kinetic heterogeneous dynamics that ultimately create interactions that enhance the binding probability of the antigen binding site. Our results indicate that the modified interfacial dynamics of anti-IFN-γ and anti-IFGNR1 that we probe experimentally are directly associated with alterations in the complementarity regions of the distinct antibodies that designate both antigen–antibody affinity and recognition.
Citations by journals
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Pharmaceutics
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2 publications, 13.33%
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Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
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Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
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1 publication, 6.67%
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1 publication, 6.67%
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Applied Sciences (Switzerland)
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Russian Physics Journal
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1 publication, 6.67%
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European Journal of Pharmaceutical Sciences
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1 publication, 6.67%
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Bulletin of Experimental Biology and Medicine
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1 publication, 6.67%
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Canadian Respiratory Journal
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Canadian Respiratory Journal
1 publication, 6.67%
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Antibiotiki i Khimioterapiya
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Antibiotiki i Khimioterapiya
1 publication, 6.67%
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Russian Journal of Gastroenterology Hepatology Coloproctology
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Russian Journal of Gastroenterology Hepatology Coloproctology
1 publication, 6.67%
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Terapevticheskii Arkhiv
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Terapevticheskii Arkhiv, 1, 6.67%
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1 publication, 6.67%
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Neurochemical Journal
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Neurochemical Journal
1 publication, 6.67%
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1
2
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Citations by publishers
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1
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3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 26.67%
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Springer Nature
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2 publications, 13.33%
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Media Sphere Publishing Group
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Media Sphere Publishing Group
2 publications, 13.33%
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International Dose-Response Society
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International Dose-Response Society, 1, 6.67%
International Dose-Response Society
1 publication, 6.67%
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Elsevier
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Elsevier
1 publication, 6.67%
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Hindawi Limited
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Hindawi Limited
1 publication, 6.67%
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Publishing House OKI
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Publishing House OKI
1 publication, 6.67%
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Russian Gastroenterolgocial Society
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Russian Gastroenterolgocial Society
1 publication, 6.67%
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Consilium Medicum
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Consilium Medicum, 1, 6.67%
Consilium Medicum
1 publication, 6.67%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 6.67%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Woods K. N. New insights into the microscopic interactions associated with the physical mechanism of action of highly diluted biologics // Scientific Reports. 2021. Vol. 11. No. 1. 13774
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Woods K. N. New insights into the microscopic interactions associated with the physical mechanism of action of highly diluted biologics // Scientific Reports. 2021. Vol. 11. No. 1. 13774
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TY - JOUR
DO - 10.1038/s41598-021-93326-1
UR - https://doi.org/10.1038%2Fs41598-021-93326-1
TI - New insights into the microscopic interactions associated with the physical mechanism of action of highly diluted biologics
T2 - Scientific Reports
AU - Woods, Kristina N
PY - 2021
DA - 2021/07/02 00:00:00
PB - Springer Nature
IS - 1
VL - 11
PMID - 34215838
SN - 2045-2322
ER -
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@article{2021_Woods,
author = {Kristina N Woods},
title = {New insights into the microscopic interactions associated with the physical mechanism of action of highly diluted biologics},
journal = {Scientific Reports},
year = {2021},
volume = {11},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1038%2Fs41598-021-93326-1},
number = {1},
doi = {10.1038/s41598-021-93326-1}
}