Open Access
Scientific Reports, volume 12, issue 1, publication number 16345
Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice
Morozova Maryana V
1, 2
,
Borisova Mariya A
3
,
Snytnikova Olga A
4
,
Achasova Kseniya M
1, 2
,
Litvinova Ekaterina A
1, 5
,
Kozhevnikova Elena N.
1, 2, 6
1
Publication type: Journal Article
Publication date: 2022-09-29
PubMed ID:
36175462
Multidisciplinary
Abstract
Inflammatory bowel diseases (IBD) are chronic and relapsing inflammatory disorders of the gastrointestinal tract with complex etiology and no strategies for complete cure. IBD are often complicated by mental disorders like anxiety and depression, indicating substantial shifts in the microbiota gut-brain axis. However, the mechanisms connecting IBD to mental diseases are still under debate. Here we use Muc2 knockout mouse model of chronic colitis to uncouple the effects of the intestinal microbiota on host behavior from chronic inflammation in the gut. Muc2 knockout male mice exhibit high exploratory activity, reduced anxiety-related behaviors, impaired sensorimotor gating, and altered social preference towards males and females. Microbial transfer to wild-type mice via littermate co-housing shows that colitis-associated microbiota rather than inflammation per se defines behavioral features in Muc2 colitis model. Metagenomic profiling and combination of antibiotic treatments revealed that bacterial species Akkermansia muciniphila is associated with the behavioral phenotype in mutants, and that its intestinal abundance correlates with social preference towards males. Metabolomic analysis together with pharmacological inhibition of Gly and NMDA receptors helped us to determine that brain glycine is responsible for the behavioral phenotype in Muc2 mice. Blood and brain metabolic profiles suggest that microbiota-dependent changes in choline metabolism might be involved in regulation of central glycine neurotransmission. Taken together, our data demonstrates that colitis-associated microbiota controls anxiety, sensorimotor gating and social behavior via metabolic regulation of the brain glycinergic system, providing new venues to combat neurological complications of IBD.
Citations by journals
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1
2
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 22.22%
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Journal of Functional Foods
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Journal of Functional Foods
1 publication, 11.11%
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Human Brain Mapping
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Human Brain Mapping
1 publication, 11.11%
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Frontiers in Neuroscience
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Frontiers in Neuroscience
1 publication, 11.11%
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Pharmaceutics
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Pharmaceutics
1 publication, 11.11%
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Journal of Evolutionary Biochemistry and Physiology
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Journal of Evolutionary Biochemistry and Physiology
1 publication, 11.11%
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1
2
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Citations by publishers
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1
2
3
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 33.33%
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Elsevier
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Elsevier
1 publication, 11.11%
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Wiley
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Wiley
1 publication, 11.11%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 11.11%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 11.11%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Morozova M. V. et al. Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice // Scientific Reports. 2022. Vol. 12. No. 1. 16345
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Morozova M. V., Borisova M. A., Snytnikova O. A., Achasova K. M., Litvinova E. A., Tsentalovich Y. P., Kozhevnikova E. N. Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice // Scientific Reports. 2022. Vol. 12. No. 1. 16345
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TY - JOUR
DO - 10.1038/s41598-022-19219-z
UR - https://doi.org/10.1038%2Fs41598-022-19219-z
TI - Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice
T2 - Scientific Reports
AU - Morozova, Maryana V
AU - Borisova, Mariya A
AU - Snytnikova, Olga A
AU - Achasova, Kseniya M
AU - Litvinova, Ekaterina A
AU - Tsentalovich, Yuri P
AU - Kozhevnikova, Elena N.
PY - 2022
DA - 2022/09/29 00:00:00
PB - Springer Nature
IS - 1
VL - 12
PMID - 36175462
SN - 2045-2322
ER -
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@article{2022_Morozova,
author = {Maryana V Morozova and Mariya A Borisova and Olga A Snytnikova and Kseniya M Achasova and Ekaterina A Litvinova and Yuri P Tsentalovich and Elena N. Kozhevnikova},
title = {Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice},
journal = {Scientific Reports},
year = {2022},
volume = {12},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1038%2Fs41598-022-19219-z},
number = {1},
doi = {10.1038/s41598-022-19219-z}
}
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