Open Access

Scientific Reports, volume 6, issue 1, publication number 28951

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

Stock Kristin ¹

Estrada Marta F ^{2, 3}

Vidic Suzana ^{4, 5, 6}

Gjerde Kjersti ^{4, 5}

Rudisch Albin ⁷

Santo Vítor E ^{2, 3}

Barbier Michaël ⁴

Blom Sami ⁸

Arundkar Sharath C ⁹

Selvam Irwin ⁷

Osswald Annika ^{7, 10}

Stein Yan ⁹

Gruenewald Sylvia ¹

Brito Catarina ^{2, 3}

van Weerden Wytske ⁵

ROTTER VARDA ⁹

Boghaert Erwin ¹¹

Oren Moshe ⁹

Sommergruber Wolfgang ⁷

Chong Yolanda ⁴

de Hoogt Ronald ⁴

Graeser Ralph ¹²

Hide authors affiliations Show authors affiliations: 12 affiliations

Bayer Pharma AG, Berlin, Germany |

iBET, Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal |

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal , |

⁴

Janssen Pharmaceutica nv, Belgium |

⁵

ERASMUS MC, The Netherlands |

⁶

Faculty of Mathematics, University of Primorska, Slovenia |

⁷

Boehringer Ingelheim RCV, GmbH & Co. KG, Doktor-Boehringer-Gasse 5-11, 1120 Wien, Austria , |

⁸

Institute for Molecular Medicine Finland FIMM, Finland |

⁹

The Weizmann Institute, Israel |

¹⁰

Institute of Medical Genetics, Medical University of Vienna, Waehringerstrasse 10, A-1090 Vienna, Austria , |

¹¹

AbbVie, 1 North Waukegan Road, IL 60064-6098, USA |

¹²

Boehringer Ingelheim Pharma GmbH & Co. KG, Germany |

Publication type: Journal Article

Publication date: 2016-07-01

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/srep28951

Copy DOI

PubMed ID: 27364600

Multidisciplinary

Abstract

Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been established and cross-comparisons made using three standard cell carcinoma lines: MCF7, LNCaP, NCI-H1437. Fluorescence-based growth curves, 3D image analysis, immunohistochemistry and treatment responses showed that end points differed according to cell type, stromal co-culture and culture format. The adaptable methodologies described here should guide the choice of appropriate simple and complex in vitro models.

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Citations by journals

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Cell Biology International	Cell Biology International, 1, 0.55% Cell Biology International 1 publication, 0.55%
	2 4 6 8 10 12

Citations by publishers

	5 10 15 20 25 30 35 40
Springer Nature	Springer Nature, 39, 21.31% Springer Nature 39 publications, 21.31%
Elsevier	Elsevier, 37, 20.22% Elsevier 37 publications, 20.22%
Wiley	Wiley, 17, 9.29% Wiley 17 publications, 9.29%
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American Chemical Society (ACS)	American Chemical Society (ACS), 7, 3.83% American Chemical Society (ACS) 7 publications, 3.83%
IOP Publishing	IOP Publishing, 5, 2.73% IOP Publishing 5 publications, 2.73%
Taylor & Francis	Taylor & Francis, 3, 1.64% Taylor & Francis 3 publications, 1.64%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 3, 1.64% American Association for Cancer Research (AACR) 3 publications, 1.64%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 2, 1.09% American Institute of Physics (AIP) 2 publications, 1.09%
Bentham Science	Bentham Science, 1, 0.55% Bentham Science 1 publication, 0.55%
F1000 Research	F1000 Research, 1, 0.55% F1000 Research 1 publication, 0.55%
Impact Journals	Impact Journals, 1, 0.55% Impact Journals 1 publication, 0.55%
The Royal Society	The Royal Society, 1, 0.55% The Royal Society 1 publication, 0.55%
Federation of American Societies for Experimental Biology (FASEB)	Federation of American Societies for Experimental Biology (FASEB), 1, 0.55% Federation of American Societies for Experimental Biology (FASEB) 1 publication, 0.55%
Oxford University Press	Oxford University Press, 1, 0.55% Oxford University Press 1 publication, 0.55%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 0.55% American Association for the Advancement of Science (AAAS) 1 publication, 0.55%
Pleiades Publishing	Pleiades Publishing, 1, 0.55% Pleiades Publishing 1 publication, 0.55%
	5 10 15 20 25 30 35 40

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GOST Copy

Stock K. et al. Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery // Scientific Reports. 2016. Vol. 6. No. 1. 28951

GOST all authors (up to 50) Copy

Stock K., Estrada M. F., Vidic S., Gjerde K., Rudisch A., Santo V. E., Barbier M., Blom S., Arundkar S. C., Selvam I., Osswald A., Stein Y., Gruenewald S., Brito C., van Weerden W., ROTTER V., Boghaert E., Oren M., Sommergruber W., Chong Y., de Hoogt R., Graeser R. Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery // Scientific Reports. 2016. Vol. 6. No. 1. 28951

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/srep28951

UR - https://doi.org/10.1038%2Fsrep28951

TI - Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

T2 - Scientific Reports

AU - Stock, Kristin

AU - Estrada, Marta F

AU - Vidic, Suzana

AU - Gjerde, Kjersti

AU - Rudisch, Albin

AU - Santo, Vítor E

AU - Barbier, Michaël

AU - Blom, Sami

AU - Arundkar, Sharath C

AU - Selvam, Irwin

AU - Osswald, Annika

AU - Stein, Yan

AU - Gruenewald, Sylvia

AU - Brito, Catarina

AU - van Weerden, Wytske

AU - ROTTER, VARDA

AU - Boghaert, Erwin

AU - Oren, Moshe

AU - Sommergruber, Wolfgang

AU - Chong, Yolanda

AU - de Hoogt, Ronald

AU - Graeser, Ralph

PY - 2016

DA - 2016/07/01 00:00:00

PB - Springer Nature

IS - 1

VL - 6

PMID - 27364600

SN - 2045-2322

ER -

BibTex

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BibTex Copy

@article{2016_Stock,

author = {Kristin Stock and Marta F Estrada and Suzana Vidic and Kjersti Gjerde and Albin Rudisch and Vítor E Santo and Michaël Barbier and Sami Blom and Sharath C Arundkar and Irwin Selvam and Annika Osswald and Yan Stein and Sylvia Gruenewald and Catarina Brito and Wytske van Weerden and VARDA ROTTER and Erwin Boghaert and Moshe Oren and Wolfgang Sommergruber and Yolanda Chong and Ronald de Hoogt and Ralph Graeser},

title = {Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery},

journal = {Scientific Reports},

year = {2016},

volume = {6},

publisher = {Springer Nature},

month = {jul},

url = {https://doi.org/10.1038%2Fsrep28951},

number = {1},

doi = {10.1038/srep28951}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)