Journal of Materials Chemistry B, volume 4, issue 1, pages 113-120
Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy.
Shi Huaxia
1
,
Sun Wucheng
1
,
Liu Changbing
1
,
Gu Guiying
2
,
Ma Bo
2
,
Si Weili
3
,
Fu Nina
1
,
Zhang Qi
2
,
Huang Wei
1, 3
,
Publication type: Journal Article
Publication date: 2016-01-01
Journal:
Journal of Materials Chemistry B
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7
ISSN: 20507518, 2050750X
General Chemistry
General Medicine
General Materials Science
Biomedical Engineering
Abstract
Specific targeting towards tumors and the on-site activation of photosensitizers to diagnose tumors and reduce side effects for patients are currently the main challenges for photodynamic therapy (PDT) in the clinic. Herein, uniform diiodostyryl bodipy conjugated hyaluronic acid nanoparticles (DBHA-NPs) were successfully synthesized. The evaluation of their PDT effect at both a cellular level and in animal models of tumor-bearing mice shows that the DBHA-NPs present a remarkable suppression of tumorous growth due to their specific targeting and enhanced permeability and retention (EPR) effect. More importantly, the enzyme-activated "self-assembly and disaggregation" behavior in tumors can lead to the on-site activation of DBHA-NPs, which can diagnose the tumor exactly and reduce the side effects for patients significantly. These findings confirm that DBHA-NPs have significant potential for photodynamically activated cancer theranostics in a clinical setting.
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1 publication, 1.96%
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1 publication, 1.96%
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Citations by publishers
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2
4
6
8
10
12
14
16
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Elsevier
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15 publications, 29.41%
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10 publications, 19.61%
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Wiley
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8 publications, 15.69%
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American Chemical Society (ACS)
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7 publications, 13.73%
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Multidisciplinary Digital Publishing Institute (MDPI)
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2 publications, 3.92%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 1.96%
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Shanghai Institute of Organic Chemistry
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Shanghai Institute of Organic Chemistry
1 publication, 1.96%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 1.96%
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Springer Nature
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Springer Nature
1 publication, 1.96%
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IOP Publishing
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IOP Publishing
1 publication, 1.96%
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KeAi Communications Co.
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KeAi Communications Co.
1 publication, 1.96%
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, 1, 1.96%
1 publication, 1.96%
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2
4
6
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10
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14
16
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Shi H. et al. Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy. // Journal of Materials Chemistry B. 2016. Vol. 4. No. 1. pp. 113-120.
GOST all authors (up to 50)
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Shi H., Sun W., Liu C., Gu G., Ma B., Si W., Fu N., Zhang Q., Huang W., Dong X. Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy. // Journal of Materials Chemistry B. 2016. Vol. 4. No. 1. pp. 113-120.
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TY - JOUR
DO - 10.1039/C5TB02041G
UR - https://doi.org/10.1039%2FC5TB02041G
TI - Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy.
T2 - Journal of Materials Chemistry B
AU - Shi, Huaxia
AU - Sun, Wucheng
AU - Liu, Changbing
AU - Gu, Guiying
AU - Fu, Nina
AU - Ma, Bo
AU - Si, Weili
AU - Zhang, Qi
AU - Huang, Wei
AU - Dong, Xiaochen
PY - 2016
DA - 2016/01/01 00:00:00
PB - Royal Society of Chemistry (RSC)
SP - 113-120
IS - 1
VL - 4
SN - 2050-7518
SN - 2050-750X
ER -
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@article{2016_Shi,
author = {Huaxia Shi and Wucheng Sun and Changbing Liu and Guiying Gu and Nina Fu and Bo Ma and Weili Si and Qi Zhang and Wei Huang and Xiaochen Dong},
title = {Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy.},
journal = {Journal of Materials Chemistry B},
year = {2016},
volume = {4},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039%2FC5TB02041G},
number = {1},
pages = {113--120},
doi = {10.1039/C5TB02041G}
}
Cite this
MLA
Copy
Shi, Huaxia, et al. “Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy..” Journal of Materials Chemistry B, vol. 4, no. 1, Jan. 2016, pp. 113-120. https://doi.org/10.1039%2FC5TB02041G.