Open Access
RSC Advances, volume 8, issue 6, pages 3274-3285
Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate drug delivery and antitumor efficiency
Zhang Zongrui
1, 2
,
Wang Xinyu
1, 2
,
Li Binbin
1, 2
,
Hou Yuanjing
1, 2
,
Cai Zhengwei
1, 2
,
Yang Jing
3
,
Li Yi
4
2
Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan 430070, China
|
4
Institute of Textiles and Clothing, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, P. R. China
|
Publication type: Journal Article
Publication date: 2018-01-16
General Chemistry
General Chemical Engineering
Abstract
The aim of this study was to develop a novel morphological paclitaxel (PTX) loaded poly(lactide-co-glycolide) (PLGA) microspheres (MS) delivery system to enhance drug delivery and antitumor efficiency as well as reduce drug administration frequency. Therefore, different morphological types of PTX-PLGA-MS were prepared using a modified solvent evaporation technique. Morphology analysis confirmed the successful preparation of the smooth PTX-PLGA-MS with internal sporadic porosity, and the novel rough PTX-PLGA-MS with microporous surface and porous internal structures. The PTX drugs were distributed in the readily bioavailable state (amorphous) in PTX-loaded MS, which allowed fast drug release from MS following intratumoral administration. The drug entrapment and release behaviors indicated that the rough MS could provide enough hydrophobic space for PTX-loading and deep surface folds for fast matrices degradation, thus achieving a higher drug-loading efficiency (17.8%) and a rapid sustained drug release effect. Furthermore, the rough MS showed strengthened in vitro anti-hepatoma efficiency than that of free PTX and smooth MS. The in vivo studies indicated remarkable antitumor activity of rough MS (tumor inhibition rate = 58.33%) for at least 13 days after a single injection, which was because the rapid sustained-release drugs could induce the pro-apoptosis gene and protein expressions, cause extensive tumor cell apoptosis, and reduce the toxicity to normal tissues. In conclusion, the rough PTX-PLGA-MS drug delivery system with outstanding tumor growth inhibition effect could serve as a promising treatment for liver tumor.
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Citations by publishers
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1 publication, 2.33%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Zhang Z. et al. Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate drug delivery and antitumor efficiency // RSC Advances. 2018. Vol. 8. No. 6. pp. 3274-3285.
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Zhang Z., Wang X., Li B., Hou Y., Cai Z., Yang J., Li Y. Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate drug delivery and antitumor efficiency // RSC Advances. 2018. Vol. 8. No. 6. pp. 3274-3285.
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TY - JOUR
DO - 10.1039/C7RA12683B
UR - https://doi.org/10.1039%2FC7RA12683B
TI - Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate drug delivery and antitumor efficiency
T2 - RSC Advances
AU - Zhang, Zongrui
AU - Wang, Xinyu
AU - Li, Binbin
AU - Hou, Yuanjing
AU - Cai, Zhengwei
AU - Yang, Jing
AU - Li, Yi
PY - 2018
DA - 2018/01/16 00:00:00
PB - Royal Society of Chemistry (RSC)
SP - 3274-3285
IS - 6
VL - 8
SN - 2046-2069
ER -
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@article{2018_Zhang,
author = {Zongrui Zhang and Xinyu Wang and Binbin Li and Yuanjing Hou and Zhengwei Cai and Jing Yang and Yi Li},
title = {Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate drug delivery and antitumor efficiency},
journal = {RSC Advances},
year = {2018},
volume = {8},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039%2FC7RA12683B},
number = {6},
pages = {3274--3285},
doi = {10.1039/C7RA12683B}
}
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MLA
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Zhang, Zongrui, et al. “Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate drug delivery and antitumor efficiency.” RSC Advances, vol. 8, no. 6, Jan. 2018, pp. 3274-3285. https://doi.org/10.1039%2FC7RA12683B.