Chemical Society Reviews, volume 50, issue 6, pages 4185-4219

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application.

Zhao Xueze ¹

Liu Jiangping ²

Fan Jiangli ^{1, 3}

Chao Hui-Lin ²

Peng Xiaojun ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, 116024 Dalian, China |

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, China |

Ningbo Institute of Dalian University of Technology, 26 Yucai Road, Jiangbei District, Ningbo, China |

Publication type: Journal Article

Publication date: 2021-02-02

Royal Society of Chemistry (RSC)

Journal: Chemical Society Reviews

Quartile SCImago

Quartile WOS

Impact factor: 46.2

ISSN: 03060012, 14604744

DOI: 10.1039/D0CS00173B

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General Chemistry

Abstract

Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been recognized as an attractive oncotherapy treatment. However, nonnegligible challenges remain for its further clinical use, including finite tumor suppression, poor tumor targeting, and limited therapeutic depth. The photosensitizer (PS), being the most important element of PDT, plays a decisive role in PDT treatment. This review summarizes recent progress made in the development of PSs for overcoming the above challenges. This progress has included PSs developed to display enhanced tolerance of the tumor microenvironment, improved tumor-specific selectivity, and feasibility of use in deep tissue. Based on their molecular photophysical properties and design directions, the PSs are classified by parent structures, which are discussed in detail from the molecular design to application. Finally, a brief summary of current strategies for designing PSs and future perspectives are also presented. We expect the information provided in this review to spur the further design of PSs and the clinical development of PDT-mediated cancer treatments.

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BMJ	BMJ, 1, 0.18% BMJ 1 publication, 0.18%
	20 40 60 80 100 120 140 160 180

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Zhao X. et al. Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application. // Chemical Society Reviews. 2021. Vol. 50. No. 6. pp. 4185-4219.

GOST all authors (up to 50) Copy

Zhao X., Liu J., Fan J., Chao H., Peng X. Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application. // Chemical Society Reviews. 2021. Vol. 50. No. 6. pp. 4185-4219.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1039/D0CS00173B

UR - https://doi.org/10.1039%2FD0CS00173B

TI - Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application.

T2 - Chemical Society Reviews

AU - Zhao, Xueze

AU - Liu, Jiangping

AU - Fan, Jiangli

AU - Chao, Hui-Lin

AU - Peng, Xiaojun

PY - 2021

DA - 2021/02/02 00:00:00

PB - Royal Society of Chemistry (RSC)

SP - 4185-4219

IS - 6

VL - 50

SN - 0306-0012

SN - 1460-4744

ER -

BibTex |

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BibTex Copy

@article{2021_Zhao,

author = {Xueze Zhao and Jiangping Liu and Jiangli Fan and Hui-Lin Chao and Xiaojun Peng},

title = {Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application.},

journal = {Chemical Society Reviews},

year = {2021},

volume = {50},

publisher = {Royal Society of Chemistry (RSC)},

month = {feb},

url = {https://doi.org/10.1039%2FD0CS00173B},

number = {6},

pages = {4185--4219},

doi = {10.1039/D0CS00173B}

}

MLA

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MLA Copy

Zhao, Xueze, et al. “Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application..” Chemical Society Reviews, vol. 50, no. 6, Feb. 2021, pp. 4185-4219. https://doi.org/10.1039%2FD0CS00173B.

Found error?

Publisher

Royal Society of Chemistry (RSC)

Journal

Chemical Society Reviews

Quartile SCImago

Quartile WOS

Impact factor

46.2

ISSN

03060012 (Print)
14604744 (Electronic)