Gastroenterology, volume 126, issue 4, pages 1147-1156

Origin and characterization of a human bipotent liver progenitor cell line☆

Parent Romain ¹

Marion Marie-Jeanne ¹

Furio Laetitia ¹

Trépo Christian ¹

Petit Marie-Anne ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

INSERM, Unité 271, Lyon, France. |

Publication type: Journal Article

Publication date: 2004-04-01

Elsevier

Journal: Gastroenterology

Quartile SCImago

Quartile WOS

Impact factor: 29.4

ISSN: 00165085, 15280012

DOI: 10.1053/j.gastro.2004.01.002

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Gastroenterology

Hepatology

Abstract

Background & Aims: Liver progenitor cells may be important in carcinogenesis resulting from human chronic liver diseases. The HepaRG cell line has been established from a liver tumor associated with chronic hepatitis C. We observed that these cells showed an evident morphological heterogeneity, displaying both hepatocyte-like and biliary-like epithelial phenotypes. Our goal was to determine whether they could share some features with liver progenitor cells. Methods: Phenotypic studies using immunofluorescence, immunoblotting, and flow cytometry were performed at different culture stages. Results: HepaRG cells progressively exhibited polarized and functional hepatocytes and bile duct-like cell features under defined conditions. Cytokeratin 18 and 19 coexpression was, however, observed all along the maturation process together with oval cell-specific markers (M2-PK, OV-1, OV-6, and CD34); kinetics and expression profiles were dependent on the cell population. In addition, a strong commitment toward the hepatocytic lineage could be observed in the presence of epidermal growth factor. Immunohistochemistry on the fibrotic liver showing the atypical ductular reaction from which HepaRG cells originated displayed a comparable immunophenotype specifically restricted to bile neoductules. Conclusions: HepaRG cells constitute the first described human hepatic bipotent progenitor cell line regarding phenotype and histological origin.

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Hepatology	Hepatology, 9, 4.79% Hepatology 9 publications, 4.79%
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PLoS ONE	PLoS ONE, 3, 1.6% PLoS ONE 3 publications, 1.6%
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Journal of Medical Virology	Journal of Medical Virology, 2, 1.06% Journal of Medical Virology 2 publications, 1.06%
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Drug Metabolism Reviews	Drug Metabolism Reviews, 2, 1.06% Drug Metabolism Reviews 2 publications, 1.06%
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Journal of Clinical Investigation	Journal of Clinical Investigation, 1, 0.53% Journal of Clinical Investigation 1 publication, 0.53%
Pharmacological Reviews	Pharmacological Reviews, 1, 0.53% Pharmacological Reviews 1 publication, 0.53%
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Citations by publishers

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Elsevier	Elsevier, 38, 20.21% Elsevier 38 publications, 20.21%
Springer Nature	Springer Nature, 31, 16.49% Springer Nature 31 publications, 16.49%
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SAGE	SAGE, 3, 1.6% SAGE 3 publications, 1.6%
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Baishideng Publishing Group	Baishideng Publishing Group, 2, 1.06% Baishideng Publishing Group 2 publications, 1.06%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 1.06% Royal Society of Chemistry (RSC) 2 publications, 1.06%
American Society for Microbiology	American Society for Microbiology, 2, 1.06% American Society for Microbiology 2 publications, 1.06%
Hindawi Limited	Hindawi Limited, 2, 1.06% Hindawi Limited 2 publications, 1.06%
Pleiades Publishing	Pleiades Publishing, 1, 0.53% Pleiades Publishing 1 publication, 0.53%
American Society for Clinical Investigation	American Society for Clinical Investigation, 1, 0.53% American Society for Clinical Investigation 1 publication, 0.53%
Bentham Science	Bentham Science, 1, 0.53% Bentham Science 1 publication, 0.53%
The Company of Biologists	The Company of Biologists, 1, 0.53% The Company of Biologists 1 publication, 0.53%
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Impact Journals	Impact Journals, 1, 0.53% Impact Journals 1 publication, 0.53%
IOS Press	IOS Press, 1, 0.53% IOS Press 1 publication, 0.53%
Second Military Medical University Press	Second Military Medical University Press, 1, 0.53% Second Military Medical University Press 1 publication, 0.53%
Federation of American Societies for Experimental Biology (FASEB)	Federation of American Societies for Experimental Biology (FASEB), 1, 0.53% Federation of American Societies for Experimental Biology (FASEB) 1 publication, 0.53%
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EMBO press	EMBO press, 1, 0.53% EMBO press 1 publication, 0.53%
American Society of Animal Science	American Society of Animal Science, 1, 0.53% American Society of Animal Science 1 publication, 0.53%
	5 10 15 20 25 30 35 40

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GOST |

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GOST Copy

Parent R. et al. Origin and characterization of a human bipotent liver progenitor cell line☆ // Gastroenterology. 2004. Vol. 126. No. 4. pp. 1147-1156.

GOST all authors (up to 50) Copy

Parent R., Marion M., Furio L., Trépo C., Petit M. Origin and characterization of a human bipotent liver progenitor cell line☆ // Gastroenterology. 2004. Vol. 126. No. 4. pp. 1147-1156.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1053/j.gastro.2004.01.002

UR - https://doi.org/10.1053%2Fj.gastro.2004.01.002

TI - Origin and characterization of a human bipotent liver progenitor cell line☆

T2 - Gastroenterology

AU - Parent, Romain

AU - Marion, Marie-Jeanne

AU - Furio, Laetitia

AU - Trépo, Christian

AU - Petit, Marie-Anne

PY - 2004

DA - 2004/04/01 00:00:00

PB - Elsevier

SP - 1147-1156

IS - 4

VL - 126

SN - 0016-5085

SN - 1528-0012

ER -

BibTex |

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BibTex Copy

@article{2004_Parent,

author = {Romain Parent and Marie-Jeanne Marion and Laetitia Furio and Christian Trépo and Marie-Anne Petit},

title = {Origin and characterization of a human bipotent liver progenitor cell line☆},

journal = {Gastroenterology},

year = {2004},

volume = {126},

publisher = {Elsevier},

month = {apr},

url = {https://doi.org/10.1053%2Fj.gastro.2004.01.002},

number = {4},

pages = {1147--1156},

doi = {10.1053/j.gastro.2004.01.002}

}

MLA

Cite this

MLA Copy

Parent, Romain, et al. “Origin and characterization of a human bipotent liver progenitor cell line☆.” Gastroenterology, vol. 126, no. 4, Apr. 2004, pp. 1147-1156. https://doi.org/10.1053%2Fj.gastro.2004.01.002.

Found error?

Publisher

Elsevier

Journal

Gastroenterology

Quartile SCImago

Quartile WOS

Impact factor

29.4

ISSN

00165085 (Print)
15280012 (Electronic)