Open Access
Gastroenterology, volume 141, issue 1, pages 326-337000
The Promoter of Human Telomerase Reverse Transcriptase Is Activated During Liver Regeneration and Hepatocyte Proliferation
Sirma Hüseyin
1
,
Kumar Mukesh
2
,
Meena Jitendra Kumar
3
,
Witt Britta
2
,
Weise Julia M
2
,
Lechel André
3
,
Satyanarayana Ande
3
,
Sakk Vadim
3
,
Guguen-Guillouzo Christiane
4
,
Zender Lars
5
,
Rudolph Karl Lenhard
3
,
Günes Cagatay
2
1
Heinrich-Pette-Institute, Hamburg, Germany,
|
2
Heinriche-Pette-Institute
3
Institute of Molecular Medicine and Max‐Planck‐Research Group on Stem Cell Aging Ulm Germany
|
4
Foie, métabolismes et cancer
5
Helmholtz Centre for Infection Research, Braunschweig, Germany
|
Publication type: Journal Article
Publication date: 2011-07-01
Journal:
Gastroenterology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 29.4
ISSN: 00165085, 15280012
Gastroenterology
Hepatology
Abstract
BACKGROUND & AIMS
Telomerase activity has not been detected in healthy human liver biopsy samples, but it is up-regulated in most human liver tumors. It is not clear whether telomerase is activated in response to acute or chronic liver injury. Telomerase activity is closely associated with expression of its catalytic subunit, telomerase reverse transcriptase (TERT). We analyzed the activity of the human TERT (hTERT) promoter during liver regeneration in vivo and hepatocyte proliferation in vitro.
METHODS
We used hTERTp-lacZ transgenic mice, which contain an 8.0-kilobase pair fragment of the hTERT gene promoter, to study the role of TERT in liver regeneration following partial hepatectomy. As an in vitro model, we used the HepaRG cell line as a new model system for human hepatocyte proliferation and differentiation.
RESULTS
Activity of the hTERT promoter increased significantly after partial hepatectomy; it was also induced in hepatocytes, based on immunohistologic analysis. Similar to the in vivo results, telomerase activity and hTERT expression were up-regulated in proliferating HepaRG cells and repressed in response to growth arrest and differentiation. Promoter mapping revealed that a proximal 0.3-kilobase pair fragment contains all elements necessary for regulation of hTERT in HepaRG cells. We identified E2F2 and E2F7 as transcription factors that control the differential expression of hTERT in proliferating hepatocytes, in vitro and in vivo.
CONCLUSIONS
hTERT is induced in hepatocytes during liver regeneration, indicating a functional role for telomerase in human liver.
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1 publication, 3.33%
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6
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Sirma H. et al. The Promoter of Human Telomerase Reverse Transcriptase Is Activated During Liver Regeneration and Hepatocyte Proliferation // Gastroenterology. 2011. Vol. 141. No. 1. pp. 326-337000.
GOST all authors (up to 50)
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Sirma H., Kumar M., Meena J. K., Witt B., Weise J. M., Lechel A., Satyanarayana A., Sakk V., Guguen-Guillouzo C., Zender L., Rudolph K. L., Günes C. The Promoter of Human Telomerase Reverse Transcriptase Is Activated During Liver Regeneration and Hepatocyte Proliferation // Gastroenterology. 2011. Vol. 141. No. 1. pp. 326-337000.
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TY - JOUR
DO - 10.1053/j.gastro.2011.03.047
UR - https://doi.org/10.1053%2Fj.gastro.2011.03.047
TI - The Promoter of Human Telomerase Reverse Transcriptase Is Activated During Liver Regeneration and Hepatocyte Proliferation
T2 - Gastroenterology
AU - Sirma, Hüseyin
AU - Kumar, Mukesh
AU - Meena, Jitendra Kumar
AU - Witt, Britta
AU - Weise, Julia M
AU - Lechel, André
AU - Satyanarayana, Ande
AU - Sakk, Vadim
AU - Guguen-Guillouzo, Christiane
AU - Zender, Lars
AU - Rudolph, Karl Lenhard
AU - Günes, Cagatay
PY - 2011
DA - 2011/07/01 00:00:00
PB - Elsevier
SP - 326-337000
IS - 1
VL - 141
SN - 0016-5085
SN - 1528-0012
ER -
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@article{2011_Sirma,
author = {Hüseyin Sirma and Mukesh Kumar and Jitendra Kumar Meena and Britta Witt and Julia M Weise and André Lechel and Ande Satyanarayana and Vadim Sakk and Christiane Guguen-Guillouzo and Lars Zender and Karl Lenhard Rudolph and Cagatay Günes},
title = {The Promoter of Human Telomerase Reverse Transcriptase Is Activated During Liver Regeneration and Hepatocyte Proliferation},
journal = {Gastroenterology},
year = {2011},
volume = {141},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1053%2Fj.gastro.2011.03.047},
number = {1},
pages = {326--337000},
doi = {10.1053/j.gastro.2011.03.047}
}
Cite this
MLA
Copy
Sirma, Hüseyin, et al. “The Promoter of Human Telomerase Reverse Transcriptase Is Activated During Liver Regeneration and Hepatocyte Proliferation.” Gastroenterology, vol. 141, no. 1, Jul. 2011, pp. 326-337000. https://doi.org/10.1053%2Fj.gastro.2011.03.047.