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Proceedings of the National Academy of Sciences of the United States of America, volume 111, issue 11, pages 4173-4178

Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5

Kim Taewan 1
Cui Ri 1, 2
Jeon Young Jun 1
Lee Jihoon 3
Lee Ju-Hee 4
Sim Hosung 5
Park Jong Kook 6
Fadda Paolo 1
Tili Esmerina 1, 7
Nakanishi Hiroshi 1
Huh Man-Il 8
Kim Sung-Hak 9, 10
Cho Ju Hwan 11
Sung Bong Hwan 12
Peng Yong 1
Lee Tae Jin 1
Luo Zhenghua 1
Sun Hui-Lung 1
Wei Huijun 1
Alder Hansjuerg 1
Oh Jeong-Su 13
Shim Kang-Sup 1
Ko Sang-Bong 14
Croce Carlo M. 1
1
 
Department of Molecular Virology, Immunology and Medical Genetics and
2
 
Department of Pathology, Affiliated Hospital of YanBian University, YanJi 133002, China;
3
 
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235;
4
 
Department of Applied Mathematics and Statistics, University of California, Santa Cruz, CA 95064;
5
 
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109;
6
 
Department of Dermatology, Northwestern University, Chicago, IL 60208;
7
 
Department of Anesthesiology, Wexner Medical Center, and
8
 
Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu 700-842, Korea;
9
 
Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210;
10
 
School of Life Sciences and Biotechnology, Korea University, Seoul 136-702, Korea;
11
 
Department of Radiation Oncology, The Ohio State University Medical Center, Arthur G. James Comprehensive Cancer Center, Columbus, OH 43210;
12
 
Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232;
13
 
Department of Genetic Engineering, Sungkyunkwan University, Suwon 110-745, Korea; and
14
 
Department of Orthopedic Surgery, Daegu Catholic University Medical Center, Catholic University of Daegu School of Medicine, Daegu 705-718, Korea
Publication typeJournal Article
Publication date2014-03-04
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor11.1
ISSN00278424, 10916490
Multidisciplinary
Abstract
Significance Many cancer-associated variants have been found in the 8q24.21 region harboring enhancer activity. However, the functional mechanism of the variants is not clear due to the lack of protein-coding genes in the region and no significant correlation with the nearest oncogene MYC. We identified long noncoding RNAs (lncRNAs) named cancer-associated region long noncoding RNAs (CARLos) in the 8q24.21 region. Interestingly, we found that the cancer-associated variant rs6983267 regulating the enhancer activity is significantly associated with the expression of one of the lncRNAs CARLo-5 and that CARLo-5 has an oncogenic function. By showing direct interaction between the enhancer region and active regulatory region of the CARLo-5 promoter, we provide a regulatory mechanism of cancer susceptibility caused by the cancer-associated variants. The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant rs6983267, increases cancer risk is unknown due to the lack of protein-coding genes at 8q24.21. Here we report the identification of long noncoding RNAs named cancer-associated region long noncoding RNAs (CARLos) in the 8q24 region. The expression of one of the long noncoding RNAs, CARLo-5, is significantly correlated with the rs6983267 allele associated with increased cancer susceptibility. We also found the MYC enhancer region physically interacts with the active regulatory region of the CARLo-5 promoter, suggesting long-range interaction of MYC enhancer with the CARLo-5 promoter regulates CARLo-5 expression. Finally, we demonstrate that CARLo-5 has a function in cell-cycle regulation and tumor development. Overall, our data provide a key of the mystery of the 8q24 gene desert.

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GOST Copy
Kim T. et al. Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5 // Proceedings of the National Academy of Sciences of the United States of America. 2014. Vol. 111. No. 11. pp. 4173-4178.
GOST all authors (up to 50) Copy
Kim T., Cui R., Jeon Y. J., Lee J., Lee J., Sim H., Park J. K., Fadda P., Tili E., Nakanishi H., Huh M., Kim S., Cho J., Sung B. H., Peng Y., Lee T. J., Luo Z., Sun H., Wei H., Alder H., Oh J., Shim K., Ko S., Croce C. M. Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5 // Proceedings of the National Academy of Sciences of the United States of America. 2014. Vol. 111. No. 11. pp. 4173-4178.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1073/pnas.1400350111
UR - https://doi.org/10.1073%2Fpnas.1400350111
TI - Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Kim, Taewan
AU - Cui, Ri
AU - Jeon, Young Jun
AU - Lee, Jihoon
AU - Lee, Ju-Hee
AU - Sim, Hosung
AU - Park, Jong Kook
AU - Fadda, Paolo
AU - Tili, Esmerina
AU - Nakanishi, Hiroshi
AU - Huh, Man-Il
AU - Kim, Sung-Hak
AU - Cho, Ju Hwan
AU - Sung, Bong Hwan
AU - Peng, Yong
AU - Lee, Tae Jin
AU - Luo, Zhenghua
AU - Sun, Hui-Lung
AU - Wei, Huijun
AU - Alder, Hansjuerg
AU - Oh, Jeong-Su
AU - Shim, Kang-Sup
AU - Ko, Sang-Bong
AU - Croce, Carlo M.
PY - 2014
DA - 2014/03/04 00:00:00
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 4173-4178
IS - 11
VL - 111
PMID - 24594601
SN - 0027-8424
SN - 1091-6490
ER -
BibTex |
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BibTex Copy
@article{2014_Kim
author = {Taewan Kim and Ri Cui and Young Jun Jeon and Jihoon Lee and Ju-Hee Lee and Hosung Sim and Jong Kook Park and Paolo Fadda and Esmerina Tili and Hiroshi Nakanishi and Man-Il Huh and Sung-Hak Kim and Ju Hwan Cho and Bong Hwan Sung and Yong Peng and Tae Jin Lee and Zhenghua Luo and Hui-Lung Sun and Huijun Wei and Hansjuerg Alder and Jeong-Su Oh and Kang-Sup Shim and Sang-Bong Ko and Carlo M. Croce},
title = {Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2014},
volume = {111},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {mar},
url = {https://doi.org/10.1073%2Fpnas.1400350111},
number = {11},
pages = {4173--4178},
doi = {10.1073/pnas.1400350111}
}
MLA
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MLA Copy
Kim, Taewan, et al. “Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5.” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 11, Mar. 2014, pp. 4173-4178. https://doi.org/10.1073%2Fpnas.1400350111.
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