Open Access
RNA Biology, volume 14, issue 10, pages 1399-1410
Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing
Publication type: Journal Article
Publication date: 2017-03-21
Journal:
RNA Biology
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4.1
ISSN: 15476286, 15558584
PubMed ID:
28277933
Molecular Biology
Cell Biology
Abstract
ABSTRACT Exon or cassette duplication is an important means of expanding protein and functional diversity through mutually exclusive splicing. However, the mechanistic basis of this process in non-arthropod species remains poorly understood. Here, we demonstrate that MRP1 genes underwent tandem exon duplication in Nematoda, Platyhelminthes, Annelida, Mollusca, Arthropoda, Echinodermata, and early-diverging Chordata but not in late-diverging vertebrates. Interestingly, these events were of independent origin in different phyla, suggesting convergent evolution of alternative splicing. Furthermore, we showed that multiple sets of clade-conserved RNA pairings evolved to guide species-specific mutually exclusive splicing in Arthropoda. Importantly, we also identified a similar structural code in MRP exon clusters of the annelid, Capitella teleta, and chordate, Branchiostoma belcheri, suggesting an evolutionarily conserved competing pairing-guided mechanism in bilaterians. Taken together, these data reveal the molecular determinants and RNA pairing-guided evolution of species-specific mutually exclusive splicing spanning more than 600 million years of bilaterian evolution. These findings have a significant impact on our understanding of the evolution of and mechanism underpinning isoform diversity and complex gene structure.
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Citations by publishers
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1
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Yuan Y. et al. Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing // RNA Biology. 2017. Vol. 14. No. 10. pp. 1399-1410.
GOST all authors (up to 50)
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Yuan Y., Hou S., Wang X., Zhan L., Cao G., Li G., Shi Y., Zhang P., Zhang P., Hong W., Lin H., Liu B., Shi F., Yang Y., Jin Y. Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing // RNA Biology. 2017. Vol. 14. No. 10. pp. 1399-1410.
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TY - JOUR
DO - 10.1080/15476286.2017.1294308
UR - https://doi.org/10.1080%2F15476286.2017.1294308
TI - Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing
T2 - RNA Biology
AU - Yuan, Yue
AU - Hou, Shouqing
AU - Zhan, Leilei
AU - Cao, Guozheng
AU - Li, Guoli
AU - Zhang, Peng
AU - Hong, Weiling
AU - Liu, Baoping
AU - Yang, Yun
AU - Jin, Yongfeng
AU - Wang, Xiu
AU - Shi, Yang
AU - Zhang, Peng
AU - Lin, Hao
AU - Shi, Feng
PY - 2017
DA - 2017/03/21 00:00:00
PB - Taylor & Francis
SP - 1399-1410
IS - 10
VL - 14
PMID - 28277933
SN - 1547-6286
SN - 1555-8584
ER -
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@article{2017_Yuan,
author = {Yue Yuan and Shouqing Hou and Leilei Zhan and Guozheng Cao and Guoli Li and Peng Zhang and Weiling Hong and Baoping Liu and Yun Yang and Yongfeng Jin and Xiu Wang and Yang Shi and Peng Zhang and Hao Lin and Feng Shi},
title = {Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing},
journal = {RNA Biology},
year = {2017},
volume = {14},
publisher = {Taylor & Francis},
month = {mar},
url = {https://doi.org/10.1080%2F15476286.2017.1294308},
number = {10},
pages = {1399--1410},
doi = {10.1080/15476286.2017.1294308}
}
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MLA
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Yuan, Yue, et al. “Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing.” RNA Biology, vol. 14, no. 10, Mar. 2017, pp. 1399-1410. https://doi.org/10.1080%2F15476286.2017.1294308.