Open Access
Nucleus, volume 6, issue 3, pages 172-178
A beginning of the end: new insights into the functional organization of telomeres
1
a Department of Cell and Molecular Biology
2
Feinberg School of Medicine
3
NORTHWESTERN UNIVERSITY
4
Chicago , IL , USA.
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Publication type: Journal Article
Publication date: 2015-05-04
Journal:
Nucleus
Quartile SCImago
Q1
Quartile WOS
Q3
Impact factor: 3.7
ISSN: 19491034, 19491042, 0864084X, 20755635
PubMed ID:
25961132
Cell Biology
Abstract
Ever since the first demonstration of their repetitive sequence and unique replication pathway, telomeres have beguiled researchers with how they function in protecting chromosome ends. Of course much has been learned over the years, and we now appreciate that telomeres are comprised of the multimeric protein/DNA shelterin complex and that the formation of t-loops provides protection from DNA damage machinery. Deriving their name from D-loops, t-loops are generated by the insertion of the 3′ overhang into telomeric repeats facilitated by the binding of TRF2. Recent studies have uncovered novel forms of chromosome end-structure that may implicate telomere organization in cellular processes beyond its essential role in telomere protection and homeostasis. In particular, we have recently described that t-loops form in a TRF2-dependent manner at interstitial telomere repeat sequences, which we termed interstitial telomere loops (ITLs). These structures are also dependent on association of lamin A/C, a canonical component of the nucleoskeleton that is mutated in myriad human diseases, including human segmental progeroid syndromes. Since ITLs are associated with telomere stability and require functional lamin A/C, our study suggests a mechanistic link between cellular aging (replicative senescence induced by telomere shortening) and organismal aging (modeled by Hutchinson Gilford Progeria Syndrome). Here we speculate on other potential ramifications of ITL formation, from gene expression to genome stability to chromosome structure.
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Citations by publishers
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6
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1 publication, 2.94%
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1 publication, 2.94%
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Sociedade Brasileira de Genetica, 1, 2.94%
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1 publication, 2.94%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Wood A. M. et al. A beginning of the end: new insights into the functional organization of telomeres // Nucleus. 2015. Vol. 6. No. 3. pp. 172-178.
GOST all authors (up to 50)
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Wood A. M., Laster K., Rice E. L., Kosak S. T. A beginning of the end: new insights into the functional organization of telomeres // Nucleus. 2015. Vol. 6. No. 3. pp. 172-178.
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RIS
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TY - JOUR
DO - 10.1080/19491034.2015.1048407
UR - https://doi.org/10.1080%2F19491034.2015.1048407
TI - A beginning of the end: new insights into the functional organization of telomeres
T2 - Nucleus
AU - Wood, Ashley M
AU - Laster, Kyle
AU - Rice, Ellen L
AU - Kosak, Steven T.
PY - 2015
DA - 2015/05/04 00:00:00
PB - Taylor & Francis
SP - 172-178
IS - 3
VL - 6
PMID - 25961132
SN - 1949-1034
SN - 1949-1042
SN - 0864-084X
SN - 2075-5635
ER -
Cite this
BibTex
Copy
@article{2015_Wood,
author = {Ashley M Wood and Kyle Laster and Ellen L Rice and Steven T. Kosak},
title = {A beginning of the end: new insights into the functional organization of telomeres},
journal = {Nucleus},
year = {2015},
volume = {6},
publisher = {Taylor & Francis},
month = {may},
url = {https://doi.org/10.1080%2F19491034.2015.1048407},
number = {3},
pages = {172--178},
doi = {10.1080/19491034.2015.1048407}
}
Cite this
MLA
Copy
Wood, Ashley M., et al. “A beginning of the end: new insights into the functional organization of telomeres.” Nucleus, vol. 6, no. 3, May. 2015, pp. 172-178. https://doi.org/10.1080%2F19491034.2015.1048407.