Molecular Biology of the Cell, volume 11, issue 12, pages 4241-4257

Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes

Gasch Audrey P. 1
Spellman Paul T. 2
Kao Camilla M 1
Carmel Harel Orna 3
Eisen Michael B. 4
Storz Gisela 3
Botstein David 2
Brown Patrick O 1
1
 
Departments of Biochemistry and
2
 
Genetics, Stanford University School of Medicine, Stanford, CA 94305-5428;
3
 
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-5430;
Publication typeJournal Article
Publication date2000-12-01
Quartile SCImago
Q1
Quartile WOS
Q3
Impact factor3.3
ISSN10591524, 19394586
Molecular Biology
Cell Biology
Abstract

We explored genomic expression patterns in the yeastSaccharomyces cerevisiae responding to diverse environmental transitions. DNA microarrays were used to measure changes in transcript levels over time for almost every yeast gene, as cells responded to temperature shocks, hydrogen peroxide, the superoxide-generating drug menadione, the sulfhydryl-oxidizing agent diamide, the disulfide-reducing agent dithiothreitol, hyper- and hypo-osmotic shock, amino acid starvation, nitrogen source depletion, and progression into stationary phase. A large set of genes (∼ 900) showed a similar drastic response to almost all of these environmental changes. Additional features of the genomic responses were specialized for specific conditions. Promoter analysis and subsequent characterization of the responses of mutant strains implicated the transcription factors Yap1p, as well as Msn2p and Msn4p, in mediating specific features of the transcriptional response, while the identification of novel sequence elements provided clues to novel regulators. Physiological themes in the genomic responses to specific environmental stresses provided insights into the effects of those stresses on the cell.

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Gasch A. P. et al. Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes // Molecular Biology of the Cell. 2000. Vol. 11. No. 12. pp. 4241-4257.
GOST all authors (up to 50) Copy
Gasch A. P., Spellman P. T., Kao C. M., Carmel Harel O., Eisen M. B., Storz G., Botstein D., Brown P. O. Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes // Molecular Biology of the Cell. 2000. Vol. 11. No. 12. pp. 4241-4257.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1091/mbc.11.12.4241
UR - https://doi.org/10.1091%2Fmbc.11.12.4241
TI - Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
T2 - Molecular Biology of the Cell
AU - Gasch, Audrey P.
AU - Spellman, Paul T.
AU - Kao, Camilla M
AU - Carmel Harel, Orna
AU - Eisen, Michael B.
AU - Storz, Gisela
AU - Botstein, David
AU - Brown, Patrick O
PY - 2000
DA - 2000/12/01 00:00:00
PB - American Society for Cell Biology (ASCB)
SP - 4241-4257
IS - 12
VL - 11
PMID - 11102521
SN - 1059-1524
SN - 1939-4586
ER -
BibTex |
Cite this
BibTex Copy
@article{2000_Gasch
author = {Audrey P. Gasch and Paul T. Spellman and Camilla M Kao and Orna Carmel Harel and Michael B. Eisen and Gisela Storz and David Botstein and Patrick O Brown},
title = {Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes},
journal = {Molecular Biology of the Cell},
year = {2000},
volume = {11},
publisher = {American Society for Cell Biology (ASCB)},
month = {dec},
url = {https://doi.org/10.1091%2Fmbc.11.12.4241},
number = {12},
pages = {4241--4257},
doi = {10.1091/mbc.11.12.4241}
}
MLA
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MLA Copy
Gasch, Audrey P., et al. “Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes.” Molecular Biology of the Cell, vol. 11, no. 12, Dec. 2000, pp. 4241-4257. https://doi.org/10.1091%2Fmbc.11.12.4241.
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