Journal of Chromatographic Science, volume 52, issue 1, pages 68-74
Development and validation of RP-HPLC method: scope of application in the determination of oil solubility of paclitaxel.
Publication type: Journal Article
Publication date: 2013-01-04
Journal:
Journal of Chromatographic Science
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 1.3
ISSN: 00219665, 1945239X
General Medicine
Analytical Chemistry
Abstract
A simple, reproducible, feasible and innovative reversed-phase high-performance liquid chromatographic method was developed and validated for the quantitative determination of paclitaxel dissolved in various oils. The method was validated after extraction of the analyte from capryol 90, triacetin and olive oil. The method was conducted on a Hypersil BDS C18 column, 250 × 4.6 mm, 5 µm particle size, with a mobile phase composed of acetonitrile: 10 mM KH2PO4 buffer (pH 3.5) (55:45, v/v) and detection at 227 nm. The linearity, in the range of 5 to 50 µg/mL, presented determination coefficients of 0.9983, 0.9997 and 0.9990 in capryol 90, triacetin and olive oil, respectively, calculated by the least-squares regression method. Intra-day precision values for percentages recovered were 0.68 to 0.80, 0.83 to 1.13 and 0.97 to 1.88, and inter day precision values were 1.52 to 1.92, 1.43 to 1.83 and 1.26 to 2.06 for capryol 90, triacetin and olive oil, respectively. The recovery of paclitaxel from the capryol 90, triacetin and olive oil ranged from 97.94 to 103.55, 96.85 to 103.27 and 97.14 to 103.64%, respectively. This developed and validated method was successfully applied to quantitatively assess paclitaxel dissolved in various oils. The solubility of paclitaxel was found to be higher in triacetin than in other tested oils.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Choudhury H. et al. Development and validation of RP-HPLC method: scope of application in the determination of oil solubility of paclitaxel. // Journal of Chromatographic Science. 2013. Vol. 52. No. 1. pp. 68-74.
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Choudhury H., Gorain B., Karmakar S., PAL T. K. Development and validation of RP-HPLC method: scope of application in the determination of oil solubility of paclitaxel. // Journal of Chromatographic Science. 2013. Vol. 52. No. 1. pp. 68-74.
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TY - JOUR
DO - 10.1093/chromsci/bms206
UR - https://doi.org/10.1093%2Fchromsci%2Fbms206
TI - Development and validation of RP-HPLC method: scope of application in the determination of oil solubility of paclitaxel.
T2 - Journal of Chromatographic Science
AU - Choudhury, Hira
AU - Gorain, Bapi
AU - Karmakar, Sanmoy
AU - PAL, Tapan Kumar
PY - 2013
DA - 2013/01/04 00:00:00
PB - Oxford University Press
SP - 68-74
IS - 1
VL - 52
SN - 0021-9665
SN - 1945-239X
ER -
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@article{2013_Choudhury,
author = {Hira Choudhury and Bapi Gorain and Sanmoy Karmakar and Tapan Kumar PAL},
title = {Development and validation of RP-HPLC method: scope of application in the determination of oil solubility of paclitaxel.},
journal = {Journal of Chromatographic Science},
year = {2013},
volume = {52},
publisher = {Oxford University Press},
month = {jan},
url = {https://doi.org/10.1093%2Fchromsci%2Fbms206},
number = {1},
pages = {68--74},
doi = {10.1093/chromsci/bms206}
}
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Choudhury, Hira, et al. “Development and validation of RP-HPLC method: scope of application in the determination of oil solubility of paclitaxel..” Journal of Chromatographic Science, vol. 52, no. 1, Jan. 2013, pp. 68-74. https://doi.org/10.1093%2Fchromsci%2Fbms206.