Open Access
Nucleic Acids Research, volume 45, issue D1, pages D158-D169
UniProt: the universal protein knowledgebase
Publication type: Journal Article
Publication date: 2016-11-29
Journal:
Nucleic Acids Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 14.9
ISSN: 03051048, 13624962
PubMed ID:
27899622
Genetics
Abstract
Abstract The UniProt knowledgebase is a large resource of protein sequences and associated detailed annotation. The database contains over 60 million sequences, of which over half a million sequences have been curated by experts who critically review experimental and predicted data for each protein. The remainder are automatically annotated based on rule systems that rely on the expert curated knowledge. Since our last update in 2014, we have more than doubled the number of reference proteomes to 5631, giving a greater coverage of taxonomic diversity. We implemented a pipeline to remove redundant highly similar proteomes that were causing excessive redundancy in UniProt. The initial run of this pipeline reduced the number of sequences in UniProt by 47 million. For our users interested in the accessory proteomes, we have made available sets of pan proteome sequences that cover the diversity of sequences for each species that is found in its strains and sub-strains. To help interpretation of genomic variants, we provide tracks of detailed protein information for the major genome browsers. We provide a SPARQL endpoint that allows complex queries of the more than 22 billion triples of data in UniProt (http://sparql.uniprot.org/). UniProt resources can be accessed via the website at http://www.uniprot.org/.
Citations by journals
|
20
40
60
80
100
120
140
|
|
|
Nucleic Acids Research
|
Nucleic Acids Research
125 publications, 3.43%
|
|
Scientific Reports
|
Scientific Reports
116 publications, 3.19%
|
|
PLoS ONE
|
PLoS ONE
73 publications, 2%
|
|
Journal of Proteome Research
|
Journal of Proteome Research
51 publications, 1.4%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
50 publications, 1.37%
|
|
Nature Communications
|
Nature Communications
49 publications, 1.35%
|
|
Bioinformatics
|
Bioinformatics
47 publications, 1.29%
|
|
Methods in Molecular Biology
|
Methods in Molecular Biology
45 publications, 1.24%
|
|
Frontiers in Microbiology
|
Frontiers in Microbiology
41 publications, 1.13%
|
|
BMC Genomics
|
BMC Genomics
40 publications, 1.1%
|
|
Briefings in Bioinformatics
|
Briefings in Bioinformatics
31 publications, 0.85%
|
|
BMC Bioinformatics
|
BMC Bioinformatics
30 publications, 0.82%
|
|
Database : the journal of biological databases and curation
|
Database : the journal of biological databases and curation
28 publications, 0.77%
|
|
eLife
|
eLife
28 publications, 0.77%
|
|
Genes
|
Genes
24 publications, 0.66%
|
|
Molecules
|
Molecules
24 publications, 0.66%
|
|
Journal of Biological Chemistry
|
Journal of Biological Chemistry
23 publications, 0.63%
|
|
PeerJ
|
PeerJ
23 publications, 0.63%
|
|
Frontiers in Genetics
|
Frontiers in Genetics
23 publications, 0.63%
|
|
Molecular and Cellular Proteomics
|
Molecular and Cellular Proteomics
22 publications, 0.6%
|
|
Computational and Structural Biotechnology Journal
|
Computational and Structural Biotechnology Journal
22 publications, 0.6%
|
|
Journal of Chemical Information and Modeling
|
Journal of Chemical Information and Modeling
22 publications, 0.6%
|
|
Scientific data
|
Scientific data
20 publications, 0.55%
|
|
Cell Reports
|
Cell Reports
20 publications, 0.55%
|
|
Proceedings of the National Academy of Sciences of the United States of America
|
Proceedings of the National Academy of Sciences of the United States of America
19 publications, 0.52%
|
|
Frontiers in Plant Science
|
Frontiers in Plant Science
17 publications, 0.47%
|
|
Frontiers in Immunology
|
Frontiers in Immunology
17 publications, 0.47%
|
|
Proteins: Structure, Function and Genetics
|
Proteins: Structure, Function and Genetics
17 publications, 0.47%
|
|
mSystems
|
mSystems
17 publications, 0.47%
|
|
20
40
60
80
100
120
140
|
Citations by publishers
|
100
200
300
400
500
600
700
|
|
|
Springer Nature
|
Springer Nature
679 publications, 18.65%
|
|
Elsevier
|
Elsevier
507 publications, 13.92%
|
|
Oxford University Press
|
Oxford University Press
319 publications, 8.76%
|
|
Wiley
|
Wiley
233 publications, 6.4%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
201 publications, 5.52%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
164 publications, 4.5%
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
155 publications, 4.26%
|
|
Public Library of Science (PLoS)
|
Public Library of Science (PLoS)
111 publications, 3.05%
|
|
American Society for Microbiology
|
American Society for Microbiology
71 publications, 1.95%
|
|
Taylor & Francis
|
Taylor & Francis
66 publications, 1.81%
|
|
American Society for Biochemistry and Molecular Biology
|
American Society for Biochemistry and Molecular Biology
46 publications, 1.26%
|
|
Hindawi Limited
|
Hindawi Limited
41 publications, 1.13%
|
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
28 publications, 0.77%
|
|
eLife Sciences Publications
|
eLife Sciences Publications
28 publications, 0.77%
|
|
Bentham Science
|
Bentham Science
26 publications, 0.71%
|
|
American Association for the Advancement of Science (AAAS)
|
American Association for the Advancement of Science (AAAS)
26 publications, 0.71%
|
|
PeerJ
|
PeerJ
24 publications, 0.66%
|
|
Proceedings of the National Academy of Sciences (PNAS)
|
Proceedings of the National Academy of Sciences (PNAS)
19 publications, 0.52%
|
|
IEEE
|
IEEE
17 publications, 0.47%
|
|
F1000 Research
|
F1000 Research
14 publications, 0.38%
|
|
Impact Journals
|
Impact Journals
13 publications, 0.36%
|
|
Microbiology Society
|
Microbiology Society
10 publications, 0.27%
|
|
Wolters Kluwer Health
|
Wolters Kluwer Health
10 publications, 0.27%
|
|
SAGE
|
SAGE
10 publications, 0.27%
|
|
Genetics Society of America
|
Genetics Society of America
10 publications, 0.27%
|
|
Cold Spring Harbor Laboratory
|
Cold Spring Harbor Laboratory
10 publications, 0.27%
|
|
International Union of Crystallography (IUCr)
|
International Union of Crystallography (IUCr)
8 publications, 0.22%
|
|
Mary Ann Liebert
|
Mary Ann Liebert
8 publications, 0.22%
|
|
Portland Press
|
Portland Press
8 publications, 0.22%
|
|
100
200
300
400
500
600
700
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","",""],"datasets":[{"label":"Citations number","data":[1,297,827,887,584,451,319,234,41],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["0.03","8.16","22.71","24.36","16.04","12.39","8.76","6.43","1.13"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Nucleic Acids Research","Scientific Reports","PLoS ONE","Journal of Proteome Research","International Journal of Molecular Sciences","Nature Communications","Bioinformatics","Methods in Molecular Biology","Frontiers in Microbiology","BMC Genomics","Briefings in Bioinformatics","BMC Bioinformatics","Database : the journal of biological databases and curation","eLife","Genes","Molecules","Journal of Biological Chemistry","PeerJ","Frontiers in Genetics","Molecular and Cellular Proteomics","Computational and Structural Biotechnology Journal","Journal of Chemical Information and Modeling","Scientific data","Cell Reports","Proceedings of the National Academy of Sciences of the United States of America","Frontiers in Plant Science","Frontiers in Immunology","Proteins: Structure, Function and Genetics","mSystems"],"ids":[23904,13767,24963,14208,14627,3231,19324,3516,24403,7708,23409,6831,21335,24138,8879,1770,19451,2875,13242,6086,4268,13608,2082,9130,306,1823,1699,19687,3395],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/eIZgkq1MRZyJ3hBkdupnUUv7wgB6zCl9D99SlPN5_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/aOPqEqNWK2Sq9T8CLDlsR6diWsFkHppx3bLsAnpx_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp"],"datasets":[{"label":"","data":[125,116,73,51,50,49,47,45,41,40,31,30,28,28,24,24,23,23,23,22,22,22,20,20,19,17,17,17,17],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[3.43,3.19,2,1.4,1.37,1.35,1.29,1.24,1.13,1.1,0.85,0.82,0.77,0.77,0.66,0.66,0.63,0.63,0.63,0.6,0.6,0.6,0.55,0.55,0.52,0.47,0.47,0.47,0.47],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Springer Nature","Elsevier","Oxford University Press","Wiley","Multidisciplinary Digital Publishing Institute (MDPI)","Frontiers Media S.A.","American Chemical Society (ACS)","Public Library of Science (PLoS)","American Society for Microbiology","Taylor & Francis","American Society for Biochemistry and Molecular Biology","Hindawi Limited","Royal Society of Chemistry (RSC)","eLife Sciences Publications","Bentham Science","American Association for the Advancement of Science (AAAS)","PeerJ","Proceedings of the National Academy of Sciences (PNAS)","IEEE","F1000 Research","Impact Journals","Microbiology Society","Wolters Kluwer Health","SAGE","Genetics Society of America","Cold Spring Harbor Laboratory","International Union of Crystallography (IUCr)","Mary Ann Liebert","Portland Press"],"ids":[8,17,19,11,202,208,40,344,142,18,2090,6921,123,6627,39,189,1089,162,6953,7910,342,827,32,31,3356,6909,730,230,801],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/eIZgkq1MRZyJ3hBkdupnUUv7wgB6zCl9D99SlPN5_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/aOPqEqNWK2Sq9T8CLDlsR6diWsFkHppx3bLsAnpx_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/6scCJegesojp2jubwY3uKCzTAmgsaH2GIFlg6Hfk_medium.webp","\/storage\/images\/resized\/WEXVM2IukNfkmwoqmPhtMKmAeERljKWAbbXmEX7m_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/RlMKyKHh4Q2iTSKF38VHwIFW4f6Ke5ChRSXbQHkq_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/ruydfaB80LDjlkYqsfOeUAZohOIODyq7bQzis5O7_medium.webp","\/storage\/images\/resized\/9EVpRifnnUJt6oHGY5GfsfSXTEz5wzbdgnZqiF5m_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/xG3oC19920mmFVqkoVEGKGaMCeoalzyvWxPkVox5_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp"],"datasets":[{"label":"","data":[679,507,319,233,201,164,155,111,71,66,46,41,28,28,26,26,24,19,17,14,13,10,10,10,10,10,8,8,8],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[18.65,13.92,8.76,6.4,5.52,4.5,4.26,3.05,1.95,1.81,1.26,1.13,0.77,0.77,0.71,0.71,0.66,0.52,0.47,0.38,0.36,0.27,0.27,0.27,0.27,0.27,0.22,0.22,0.22],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}