Open Access
Nucleic Acids Research, volume 45, issue 18, pages 10492-10503
PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells
Hsieh Meng-Hsun
1
,
Chen Yi-Ting
1
,
Chen You Tzung
2
,
Lee Yi-Hsuan
3
,
Lu Jean
3
,
Chien Chung-Liang
4
,
Chen Shee-Ping
5
,
Ho Hong Meng
5
,
Yu Jau-Song
6, 7
,
Wang Zhao-Qi
8
,
TENG SHU WEI
9
1
3
Genomics research Center, Academia Sinica, Taipei 115, Taiwan
|
7
Department of Thoracic Medicine, Chang Gung Memorial Hospital, Linkou, Tao-Yuan 333, Taiwan.
|
8
Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), 07745 Jena, Germany
|
Publication type: Journal Article
Publication date: 2017-08-01
Journal:
Nucleic Acids Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 14.9
ISSN: 03051048, 13624962
PubMed ID:
28985359
Genetics
Abstract
Abstract Telomerase is highly expressed in cancer and embryonic stem cells (ESCs) and implicated in controlling genome integrity, cancer formation and stemness. Previous studies identified that Krüppel-like transcription factor 4 (KLF4) activates telomerase reverse transcriptase (TERT) expression and contributes to the maintenance of self-renewal in ESCs. However, little is known about how KLF4 regulates TERT expression. Here, we discover poly(ADP-ribose) polymerase 1 (PARP1) as a novel KLF4-interacting partner. Knockdown of PARP1 reduces TERT expression and telomerase activity not only in cancer cells, but also in human and mouse ESCs. Recruitment of KLF4 to TERT promoter is reduced in PARP1-suppressed cells. The poly(ADP-ribose) polymerase activity is dispensable, while the oligo(ADP-ribose) polymerase activity is required for the PARP1- and KLF4-mediated TERT activation. Repression of Parp1 in mouse ESCs decreases expression of pluripotent markers and induces differentiation. These results suggest that PARP1 recruits KLF4 to activate telomerase expression and stem cell pluripotency, indicating a positive regulatory role of the PARP1–KLF4 complex in telomerase expression in cancer and stem cells.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Hsieh M. et al. PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells // Nucleic Acids Research. 2017. Vol. 45. No. 18. pp. 10492-10503.
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Hsieh M., Chen Y., Chen Y. T., Lee Y., Lu J., Chien C., Chen S., Ho H. M., Yu J., Wang Z., TENG S. W. PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells // Nucleic Acids Research. 2017. Vol. 45. No. 18. pp. 10492-10503.
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TY - JOUR
DO - 10.1093/nar/gkx683
UR - https://doi.org/10.1093%2Fnar%2Fgkx683
TI - PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells
T2 - Nucleic Acids Research
AU - Hsieh, Meng-Hsun
AU - Lee, Yi-Hsuan
AU - Wang, Zhao-Qi
AU - Chen, Yi-Ting
AU - Chen, You Tzung
AU - Lu, Jean
AU - Chien, Chung-Liang
AU - Chen, Shee-Ping
AU - Ho, Hong Meng
AU - Yu, Jau-Song
AU - TENG, SHU WEI
PY - 2017
DA - 2017/08/01 00:00:00
PB - Oxford University Press
SP - 10492-10503
IS - 18
VL - 45
PMID - 28985359
SN - 0305-1048
SN - 1362-4962
ER -
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@article{2017_Hsieh,
author = {Meng-Hsun Hsieh and Yi-Hsuan Lee and Zhao-Qi Wang and Yi-Ting Chen and You Tzung Chen and Jean Lu and Chung-Liang Chien and Shee-Ping Chen and Hong Meng Ho and Jau-Song Yu and SHU WEI TENG},
title = {PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells},
journal = {Nucleic Acids Research},
year = {2017},
volume = {45},
publisher = {Oxford University Press},
month = {aug},
url = {https://doi.org/10.1093%2Fnar%2Fgkx683},
number = {18},
pages = {10492--10503},
doi = {10.1093/nar/gkx683}
}
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MLA
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Hsieh, Meng-Hsun, et al. “PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.” Nucleic Acids Research, vol. 45, no. 18, Aug. 2017, pp. 10492-10503. https://doi.org/10.1093%2Fnar%2Fgkx683.