Open Access
Nucleic Acids Research, volume 47, issue 12, pages 6250-6268
The telomeric Cdc13–Stn1–Ten1 complex regulates RNA polymerase II transcription
Calvo O
1
,
Grandin Nathalie
2
,
Jordán Pla Antonio
3
,
Miñambres Esperanza
1
,
González Polo Noelia
1
,
Pérez-Ortı́n José E
3
,
Charbonneau Michel
2
1
Instituto de Biología Funcional y Genómica, CSIC-USAL, Salamanca, Spain
|
2
GReD laboratory, CNRS UMR6293, INSERM U1103, Faculty of Medicine, University Clermont-Auvergne, 28 place Henri Dunant, BP 38, 63001 Clermont-Ferrand Cedex, France
|
3
ERI Biotecmed, Facultad de Ciencias Biológicas, Universitat de València, C/Dr. Moliner 50, E46100 Burjassot, Spain
|
Publication type: Journal Article
Publication date: 2019-04-22
Journal:
Nucleic Acids Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 14.9
ISSN: 03051048, 13624962
PubMed ID:
31006804
Genetics
Abstract
Abstract Specialized telomeric proteins have an essential role in maintaining genome stability through chromosome end protection and telomere length regulation. In the yeast Saccharomyces cerevisiae, the evolutionary conserved CST complex, composed of the Cdc13, Stn1 and Ten1 proteins, largely contributes to these functions. Here, we report genetic interactions between TEN1 and several genes coding for transcription regulators. Molecular assays confirmed this novel function of Ten1 and further established that it regulates the occupancies of RNA polymerase II and the Spt5 elongation factor within transcribed genes. Since Ten1, but also Cdc13 and Stn1, were found to physically associate with Spt5, we propose that Spt5 represents the target of CST in transcription regulation. Moreover, CST physically associates with Hmo1, previously shown to mediate the architecture of S-phase transcribed genes. The fact that, genome-wide, the promoters of genes down-regulated in the ten1-31 mutant are prefentially bound by Hmo1, leads us to propose a potential role for CST in synchronizing transcription with replication fork progression following head-on collisions.
Citations by journals
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1
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eLife
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eLife
1 publication, 12.5%
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Cancer genetics
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Cancer genetics
1 publication, 12.5%
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Journal of Biological Chemistry
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Journal of Biological Chemistry
1 publication, 12.5%
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DNA Repair
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DNA Repair
1 publication, 12.5%
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Science advances
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Science advances
1 publication, 12.5%
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1
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Citations by publishers
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1
2
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Elsevier
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Elsevier
2 publications, 25%
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eLife Sciences Publications
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eLife Sciences Publications
1 publication, 12.5%
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American Society for Biochemistry and Molecular Biology
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American Society for Biochemistry and Molecular Biology
1 publication, 12.5%
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American Association for the Advancement of Science (AAAS)
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American Association for the Advancement of Science (AAAS)
1 publication, 12.5%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Calvo O. et al. The telomeric Cdc13–Stn1–Ten1 complex regulates RNA polymerase II transcription // Nucleic Acids Research. 2019. Vol. 47. No. 12. pp. 6250-6268.
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Calvo O., Grandin N., Jordán Pla A., Miñambres E., González Polo N., Pérez-Ortı́n J. E., Charbonneau M. The telomeric Cdc13–Stn1–Ten1 complex regulates RNA polymerase II transcription // Nucleic Acids Research. 2019. Vol. 47. No. 12. pp. 6250-6268.
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TY - JOUR
DO - 10.1093/nar/gkz279
UR - https://doi.org/10.1093%2Fnar%2Fgkz279
TI - The telomeric Cdc13–Stn1–Ten1 complex regulates RNA polymerase II transcription
T2 - Nucleic Acids Research
AU - Calvo, O
AU - Grandin, Nathalie
AU - Miñambres, Esperanza
AU - González Polo, Noelia
AU - Pérez-Ortı́n, José E
AU - Charbonneau, Michel
AU - Jordán Pla, Antonio
PY - 2019
DA - 2019/04/22 00:00:00
PB - Oxford University Press
SP - 6250-6268
IS - 12
VL - 47
PMID - 31006804
SN - 0305-1048
SN - 1362-4962
ER -
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@article{2019_Calvo,
author = {O Calvo and Nathalie Grandin and Esperanza Miñambres and Noelia González Polo and José E Pérez-Ortı́n and Michel Charbonneau and Antonio Jordán Pla},
title = {The telomeric Cdc13–Stn1–Ten1 complex regulates RNA polymerase II transcription},
journal = {Nucleic Acids Research},
year = {2019},
volume = {47},
publisher = {Oxford University Press},
month = {apr},
url = {https://doi.org/10.1093%2Fnar%2Fgkz279},
number = {12},
pages = {6250--6268},
doi = {10.1093/nar/gkz279}
}
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MLA
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Calvo, O., et al. “The telomeric Cdc13–Stn1–Ten1 complex regulates RNA polymerase II transcription.” Nucleic Acids Research, vol. 47, no. 12, Apr. 2019, pp. 6250-6268. https://doi.org/10.1093%2Fnar%2Fgkz279.