Open Access
Open Biology, volume 7, issue 3, pages 160338
Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells
Publication type: Journal Article
Publication date: 2017-03-22
PubMed ID:
28330934
General Biochemistry, Genetics and Molecular Biology
General Neuroscience
Immunology
Abstract
Aberrant activation of telomerase occurs in 85–90% of all cancers and underpins the ability of cancer cells to bypass their proliferative limit, rendering them immortal. The activity of telomerase is tightly controlled at multiple levels, from transcriptional regulation of the telomerase components to holoenzyme biogenesis and recruitment to the telomere, and finally activation and processivity. However, studies using cancer cell lines and other model systems have begun to reveal features of telomeres and telomerase that are unique to cancer. This review summarizes our current knowledge on the mechanisms of telomerase recruitment and activation using insights from studies in mammals and budding and fission yeasts. Finally, we discuss the differences in telomere homeostasis between normal cells and cancer cells, which may provide a foundation for telomere/telomerase targeted cancer treatments.
Citations by journals
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2 publications, 3.23%
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1 publication, 1.61%
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Molecular Biology Reports
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1 publication, 1.61%
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FASEB Journal
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1 publication, 1.61%
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1 publication, 1.61%
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1 publication, 1.61%
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Cell Reports
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1 publication, 1.61%
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Analytica Chimica Acta
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1 publication, 1.61%
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Journal of Molecular Biology
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1 publication, 1.61%
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1 publication, 1.61%
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Journal of Cellular Biochemistry
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1 publication, 1.61%
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1 publication, 1.61%
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1 publication, 1.61%
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1 publication, 1.61%
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1 publication, 1.61%
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1 publication, 1.61%
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1 publication, 1.61%
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Citations by publishers
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10 publications, 16.13%
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Wiley
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7 publications, 11.29%
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6 publications, 9.68%
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Elsevier
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6 publications, 9.68%
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3 publications, 4.84%
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Taylor & Francis
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2 publications, 3.23%
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Frontiers Media S.A.
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2 publications, 3.23%
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American Society for Biochemistry and Molecular Biology
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2 publications, 3.23%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
2 publications, 3.23%
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Genetics Society of America
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2 publications, 3.23%
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Portland Press
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Portland Press
1 publication, 1.61%
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Federation of American Societies for Experimental Biology (FASEB)
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1 publication, 1.61%
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Public Library of Science (PLoS)
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1 publication, 1.61%
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Meditsinski Universitet - Sofia
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Meditsinski Universitet - Sofia, 1, 1.61%
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1 publication, 1.61%
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American Society for Microbiology
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1 publication, 1.61%
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1 publication, 1.61%
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Cold Spring Harbor Laboratory
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1 publication, 1.61%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Armstrong C. A., Tomita K. Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells // Open Biology. 2017. Vol. 7. No. 3. p. 160338.
GOST all authors (up to 50)
Copy
Armstrong C. A., Tomita K. Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells // Open Biology. 2017. Vol. 7. No. 3. p. 160338.
Cite this
RIS
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TY - JOUR
DO - 10.1098/rsob.160338
UR - https://doi.org/10.1098%2Frsob.160338
TI - Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells
T2 - Open Biology
AU - Armstrong, Christine A.
AU - Tomita, Kazunori
PY - 2017
DA - 2017/03/22 00:00:00
PB - The Royal Society
SP - 160338
IS - 3
VL - 7
PMID - 28330934
SN - 2046-2441
ER -
Cite this
BibTex
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@article{2017_Armstrong,
author = {Christine A. Armstrong and Kazunori Tomita},
title = {Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells},
journal = {Open Biology},
year = {2017},
volume = {7},
publisher = {The Royal Society},
month = {mar},
url = {https://doi.org/10.1098%2Frsob.160338},
number = {3},
pages = {160338},
doi = {10.1098/rsob.160338}
}
Cite this
MLA
Copy
Armstrong, Christine A., and Kazunori Tomita. “Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells.” Open Biology, vol. 7, no. 3, Mar. 2017, p. 160338. https://doi.org/10.1098%2Frsob.160338.