Cold Spring Harbor perspectives in medicine, volume 6, issue 9, pages a025361
Bacterial Protein Synthesis as a Target for Antibiotic Inhibition
1
Center for Integrated Protein Science Munich (CiPSM), University of Munich, 81377 Munich, Germany.
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2
Center for Integrated Protein Science Munich (CiPSM), University of Munich, 81377 Munich, Germany Gene Center and Department for Biochemistry, University of Munich, 81377 Munich, Germany.
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Publication type: Journal Article
Publication date: 2016-08-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.4
ISSN: 21571422
PubMed ID:
27481773
General Biochemistry, Genetics and Molecular Biology
Abstract
Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial ribosomes and the translational machinery represent one of the major targets for antibiotics in the cell. Therefore, structural and biochemical investigations into ribosome-targeting antibiotics provide not only insight into the mechanism of action and resistance of antibiotics, but also insight into the fundamental process of protein synthesis. This review summarizes the recent advances in our understanding of protein synthesis, particularly with respect to X-ray and cryoelectron microscopy (cryo-EM) structures of ribosome complexes, and highlights the different steps of translation that are targeted by the diverse array of known antibiotics. Such findings will be important for the ongoing development of novel and improved antimicrobial agents to combat the rapid emergence of multidrug resistant pathogenic bacteria.
Citations by journals
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3
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Molecules
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3 publications, 3.45%
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Nucleic Acids Research
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2 publications, 2.3%
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2 publications, 2.3%
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Nature Communications
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2 publications, 2.3%
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Biochemistry (Moscow)
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1 publication, 1.15%
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Biochimie
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1 publication, 1.15%
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Microbial genomics
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1 publication, 1.15%
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Bioinformatics and Biology Insights
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1 publication, 1.15%
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Cancers
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1 publication, 1.15%
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Frontiers in Genetics
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Frontiers in Genetics
1 publication, 1.15%
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Journal of Functional Biomaterials
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Journal of Functional Biomaterials
1 publication, 1.15%
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Pharmaceutical Chemistry Journal
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Pharmaceutical Chemistry Journal
1 publication, 1.15%
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Communications Biology
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Communications Biology
1 publication, 1.15%
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Amino Acids
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Amino Acids
1 publication, 1.15%
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European Journal of Clinical Pharmacology
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European Journal of Clinical Pharmacology
1 publication, 1.15%
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Nature Chemical Biology
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Nature Chemical Biology
1 publication, 1.15%
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BMC Biology
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BMC Biology
1 publication, 1.15%
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Journal of Membrane Science
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Journal of Membrane Science
1 publication, 1.15%
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Engineering
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Engineering
1 publication, 1.15%
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Heliyon
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Heliyon
1 publication, 1.15%
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Journal of Magnesium and Alloys
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Journal of Magnesium and Alloys
1 publication, 1.15%
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PLoS Genetics
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PLoS Genetics
1 publication, 1.15%
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1
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3
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Citations by publishers
2
4
6
8
10
12
14
16
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Springer Nature
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Springer Nature
15 publications, 17.24%
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Elsevier
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Elsevier
13 publications, 14.94%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
9 publications, 10.34%
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Wiley
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Wiley
9 publications, 10.34%
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Oxford University Press
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Oxford University Press
6 publications, 6.9%
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Frontiers Media S.A.
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Frontiers Media S.A.
3 publications, 3.45%
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American Society for Microbiology
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American Society for Microbiology
2 publications, 2.3%
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Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS)
2 publications, 2.3%
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Annual Reviews
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Annual Reviews
2 publications, 2.3%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 1.15%
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Microbiology Society
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Microbiology Society
1 publication, 1.15%
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SAGE
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SAGE
1 publication, 1.15%
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KeAi Communications Co.
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KeAi Communications Co.
1 publication, 1.15%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
1 publication, 1.15%
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Taylor & Francis
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Taylor & Francis
1 publication, 1.15%
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Acta Naturae Ltd
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Acta Naturae Ltd, 1, 1.15%
Acta Naturae Ltd
1 publication, 1.15%
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eLife Sciences Publications
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eLife Sciences Publications
1 publication, 1.15%
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Cold Spring Harbor Laboratory
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Cold Spring Harbor Laboratory
1 publication, 1.15%
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Belgorod National Research University
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Belgorod National Research University
1 publication, 1.15%
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IOP Publishing
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IOP Publishing
1 publication, 1.15%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Arenz S., Wilson D. W. Bacterial Protein Synthesis as a Target for Antibiotic Inhibition // Cold Spring Harbor perspectives in medicine. 2016. Vol. 6. No. 9. p. a025361.
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Arenz S., Wilson D. W. Bacterial Protein Synthesis as a Target for Antibiotic Inhibition // Cold Spring Harbor perspectives in medicine. 2016. Vol. 6. No. 9. p. a025361.
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RIS
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TY - JOUR
DO - 10.1101/cshperspect.a025361
UR - https://doi.org/10.1101%2Fcshperspect.a025361
TI - Bacterial Protein Synthesis as a Target for Antibiotic Inhibition
T2 - Cold Spring Harbor perspectives in medicine
AU - Arenz, Stefan
AU - Wilson, Daniel W.
PY - 2016
DA - 2016/08/01 00:00:00
PB - Cold Spring Harbor Laboratory
SP - a025361
IS - 9
VL - 6
PMID - 27481773
SN - 2157-1422
ER -
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BibTex
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@article{2016_Arenz
author = {Stefan Arenz and Daniel W. Wilson},
title = {Bacterial Protein Synthesis as a Target for Antibiotic Inhibition},
journal = {Cold Spring Harbor perspectives in medicine},
year = {2016},
volume = {6},
publisher = {Cold Spring Harbor Laboratory},
month = {aug},
url = {https://doi.org/10.1101%2Fcshperspect.a025361},
number = {9},
pages = {a025361},
doi = {10.1101/cshperspect.a025361}
}
Cite this
MLA
Copy
Arenz, Stefan, and Daniel W. Wilson. “Bacterial Protein Synthesis as a Target for Antibiotic Inhibition.” Cold Spring Harbor perspectives in medicine, vol. 6, no. 9, Aug. 2016, p. a025361. https://doi.org/10.1101%2Fcshperspect.a025361.