Cold Spring Harbor perspectives in medicine, volume 6, issue 9, pages a025361

Bacterial Protein Synthesis as a Target for Antibiotic Inhibition

Arenz Stefan 1
1
 
Center for Integrated Protein Science Munich (CiPSM), University of Munich, 81377 Munich, Germany.
2
 
Center for Integrated Protein Science Munich (CiPSM), University of Munich, 81377 Munich, Germany Gene Center and Department for Biochemistry, University of Munich, 81377 Munich, Germany.
Publication typeJournal Article
Publication date2016-08-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor5.4
ISSN21571422
General Biochemistry, Genetics and Molecular Biology
Abstract
Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial ribosomes and the translational machinery represent one of the major targets for antibiotics in the cell. Therefore, structural and biochemical investigations into ribosome-targeting antibiotics provide not only insight into the mechanism of action and resistance of antibiotics, but also insight into the fundamental process of protein synthesis. This review summarizes the recent advances in our understanding of protein synthesis, particularly with respect to X-ray and cryoelectron microscopy (cryo-EM) structures of ribosome complexes, and highlights the different steps of translation that are targeted by the diverse array of known antibiotics. Such findings will be important for the ongoing development of novel and improved antimicrobial agents to combat the rapid emergence of multidrug resistant pathogenic bacteria.

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Arenz S., Wilson D. W. Bacterial Protein Synthesis as a Target for Antibiotic Inhibition // Cold Spring Harbor perspectives in medicine. 2016. Vol. 6. No. 9. p. a025361.
GOST all authors (up to 50) Copy
Arenz S., Wilson D. W. Bacterial Protein Synthesis as a Target for Antibiotic Inhibition // Cold Spring Harbor perspectives in medicine. 2016. Vol. 6. No. 9. p. a025361.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1101/cshperspect.a025361
UR - https://doi.org/10.1101%2Fcshperspect.a025361
TI - Bacterial Protein Synthesis as a Target for Antibiotic Inhibition
T2 - Cold Spring Harbor perspectives in medicine
AU - Arenz, Stefan
AU - Wilson, Daniel W.
PY - 2016
DA - 2016/08/01 00:00:00
PB - Cold Spring Harbor Laboratory
SP - a025361
IS - 9
VL - 6
PMID - 27481773
SN - 2157-1422
ER -
BibTex |
Cite this
BibTex Copy
@article{2016_Arenz
author = {Stefan Arenz and Daniel W. Wilson},
title = {Bacterial Protein Synthesis as a Target for Antibiotic Inhibition},
journal = {Cold Spring Harbor perspectives in medicine},
year = {2016},
volume = {6},
publisher = {Cold Spring Harbor Laboratory},
month = {aug},
url = {https://doi.org/10.1101%2Fcshperspect.a025361},
number = {9},
pages = {a025361},
doi = {10.1101/cshperspect.a025361}
}
MLA
Cite this
MLA Copy
Arenz, Stefan, and Daniel W. Wilson. “Bacterial Protein Synthesis as a Target for Antibiotic Inhibition.” Cold Spring Harbor perspectives in medicine, vol. 6, no. 9, Aug. 2016, p. a025361. https://doi.org/10.1101%2Fcshperspect.a025361.
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