Open Access
Genes and Development, volume 11, issue 21, pages 2790-2800
Functionally interacting telomerase RNAs in the yeast telomerase complex
1
Department of Microbiology, University of California, San Francisco, San Francisco, California 94143-0414 USA.
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Publication type: Journal Article
Publication date: 1997-11-01
Journal:
Genes and Development
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 10.5
ISSN: 08909369, 15495477
PubMed ID:
9353249
Genetics
Developmental Biology
Abstract
The ribonucleoprotein (RNP) enzyme telomerase from Saccharomyces cerevisiae adds telomeric DNA to chromosomal ends in short increments both in vivo and in vitro. Whether or not telomerase functions as a multimer has not been addressed previously. Here we show, first, that following polymerization, the telomerase RNP remains stably bound to its telomeric oligonucleotide reaction product. We then exploit this finding and a previously reported mutant telomerase RNA to demonstrate that, unexpectedly, the S. cerevisiae telomerase complex contains at least two functionally interacting RNA molecules that both act as templates for DNA polymerization. Here, functional telomerase contains at least two active sites.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
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GOST
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Prescott J., Blackburn E. Functionally interacting telomerase RNAs in the yeast telomerase complex // Genes and Development. 1997. Vol. 11. No. 21. pp. 2790-2800.
GOST all authors (up to 50)
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Prescott J., Blackburn E. Functionally interacting telomerase RNAs in the yeast telomerase complex // Genes and Development. 1997. Vol. 11. No. 21. pp. 2790-2800.
Cite this
RIS
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TY - JOUR
DO - 10.1101/gad.11.21.2790
UR - https://doi.org/10.1101%2Fgad.11.21.2790
TI - Functionally interacting telomerase RNAs in the yeast telomerase complex
T2 - Genes and Development
AU - Prescott, J.
AU - Blackburn, Elizabeth
PY - 1997
DA - 1997/11/01 00:00:00
PB - Cold Spring Harbor Laboratory
SP - 2790-2800
IS - 21
VL - 11
PMID - 9353249
SN - 0890-9369
SN - 1549-5477
ER -
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@article{1997_Prescott,
author = {J. Prescott and Elizabeth Blackburn},
title = {Functionally interacting telomerase RNAs in the yeast telomerase complex},
journal = {Genes and Development},
year = {1997},
volume = {11},
publisher = {Cold Spring Harbor Laboratory},
month = {nov},
url = {https://doi.org/10.1101%2Fgad.11.21.2790},
number = {21},
pages = {2790--2800},
doi = {10.1101/gad.11.21.2790}
}
Cite this
MLA
Copy
Prescott, J., and Elizabeth Blackburn. “Functionally interacting telomerase RNAs in the yeast telomerase complex.” Genes and Development, vol. 11, no. 21, Nov. 1997, pp. 2790-2800. https://doi.org/10.1101%2Fgad.11.21.2790.