Open Access
Genes and Development, volume 12, issue 8, pages 1073-1085
The telomerase reverse transcriptase: components and regulation
1
Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
|
Publication type: Journal Article
Publication date: 1998-04-15
Journal:
Genes and Development
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 10.5
ISSN: 08909369, 15495477
Genetics
Developmental Biology
Abstract
The idea that chromosomes have special terminal structures first arose as a consequence of experiments conducted by Muller, who found that treatment of Drosophila with X-rays rarely resulted in terminal deletions or inversions of the chromosomes (Muller 1938). Complementary experiments in maize by McClintock expanded upon the idea that telomeres, the physical ends of chromosomes, are required for chromosome stability, by contrasting the breakage-fusion-bridge cycle resulting from broken dicentric chromosomes with the stability of chromosomes with intact termini (McClintock 1941, 1942). With the dawn of molecular biology, telomeres in most eukaryotes are now known to be composed of short repeated G-rich sequences complexed with proteins to form a special heterochromatin-like structure. More recent experimental manipulation of chromosome termini and of the proteins that bind them have confirmed the early observations of Muller and McClintock, showing that a primary role of telomeres is to insulate the ends of chromosomes both from fusion with other ends and
Citations by journals
|
5
10
15
20
25
30
|
|
|
Molecular and Cellular Biology
|
Molecular and Cellular Biology
27 publications, 8.41%
|
|
Journal of Biological Chemistry
|
Journal of Biological Chemistry
19 publications, 5.92%
|
|
Oncogene
|
Oncogene
11 publications, 3.43%
|
|
Proceedings of the National Academy of Sciences of the United States of America
|
Proceedings of the National Academy of Sciences of the United States of America
8 publications, 2.49%
|
|
Genetics
|
Genetics
7 publications, 2.18%
|
|
Current Biology
|
Current Biology
6 publications, 1.87%
|
|
Molecular Biology of the Cell
|
Molecular Biology of the Cell
6 publications, 1.87%
|
|
Molecular Cell
|
Molecular Cell
5 publications, 1.56%
|
|
Biochemical and Biophysical Research Communications
|
Biochemical and Biophysical Research Communications
5 publications, 1.56%
|
|
Nucleic Acids Research
|
Nucleic Acids Research
5 publications, 1.56%
|
|
FEBS Letters
|
FEBS Letters
4 publications, 1.25%
|
|
Journal of Cell Science
|
Journal of Cell Science
4 publications, 1.25%
|
|
Nature
|
Nature
4 publications, 1.25%
|
|
Nature Genetics
|
Nature Genetics
4 publications, 1.25%
|
|
Science
|
Science
4 publications, 1.25%
|
|
Current Opinion in Genetics and Development
|
Current Opinion in Genetics and Development
3 publications, 0.93%
|
|
Experimental Cell Research
|
Experimental Cell Research
3 publications, 0.93%
|
|
Current Opinion in Cell Biology
|
Current Opinion in Cell Biology
3 publications, 0.93%
|
|
Cancer Letters
|
Cancer Letters
3 publications, 0.93%
|
|
Cancer Cell
|
Cancer Cell
3 publications, 0.93%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
3 publications, 0.93%
|
|
PLoS ONE
|
PLoS ONE
3 publications, 0.93%
|
|
Blood
|
Blood
3 publications, 0.93%
|
|
Genes and Development
|
Genes and Development
3 publications, 0.93%
|
|
Biochimie
|
Biochimie
2 publications, 0.62%
|
|
Cell
|
Cell
2 publications, 0.62%
|
|
Biochemical Pharmacology
|
Biochemical Pharmacology
2 publications, 0.62%
|
|
Journal of Molecular and Cellular Cardiology
|
Journal of Molecular and Cellular Cardiology
2 publications, 0.62%
|
|
Trends in Biochemical Sciences
|
Trends in Biochemical Sciences
2 publications, 0.62%
|
|
5
10
15
20
25
30
|
Citations by publishers
|
10
20
30
40
50
60
70
80
90
|
|
|
Elsevier
|
Elsevier
82 publications, 25.55%
|
|
Springer Nature
|
Springer Nature
45 publications, 14.02%
|
|
American Society for Microbiology
|
American Society for Microbiology
31 publications, 9.66%
|
|
Wiley
|
Wiley
27 publications, 8.41%
|
|
American Society for Biochemistry and Molecular Biology
|
American Society for Biochemistry and Molecular Biology
19 publications, 5.92%
|
|
Proceedings of the National Academy of Sciences (PNAS)
|
Proceedings of the National Academy of Sciences (PNAS)
8 publications, 2.49%
|
|
Genetics Society of America
|
Genetics Society of America
7 publications, 2.18%
|
|
Wolters Kluwer Health
|
Wolters Kluwer Health
6 publications, 1.87%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
6 publications, 1.87%
|
|
Taylor & Francis
|
Taylor & Francis
6 publications, 1.87%
|
|
American Society for Cell Biology (ASCB)
|
American Society for Cell Biology (ASCB)
6 publications, 1.87%
|
|
Oxford University Press
|
Oxford University Press
5 publications, 1.56%
|
|
The Company of Biologists
|
The Company of Biologists
4 publications, 1.25%
|
|
Public Library of Science (PLoS)
|
Public Library of Science (PLoS)
4 publications, 1.25%
|
|
American Association for the Advancement of Science (AAAS)
|
American Association for the Advancement of Science (AAAS)
4 publications, 1.25%
|
|
Cold Spring Harbor Laboratory
|
Cold Spring Harbor Laboratory
4 publications, 1.25%
|
|
Pleiades Publishing
|
Pleiades Publishing
3 publications, 0.93%
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
3 publications, 0.93%
|
|
American Society of Hematology
|
American Society of Hematology
3 publications, 0.93%
|
|
American Association for Cancer Research (AACR)
|
American Association for Cancer Research (AACR)
2 publications, 0.62%
|
|
American Thoracic Society
|
American Thoracic Society
1 publication, 0.31%
|
|
CSIRO Publishing
|
CSIRO Publishing
1 publication, 0.31%
|
|
The Endocrine Society
|
The Endocrine Society
1 publication, 0.31%
|
|
Impact Journals
|
Impact Journals
1 publication, 0.31%
|
|
IOS Press
|
IOS Press
1 publication, 0.31%
|
|
Mary Ann Liebert
|
Mary Ann Liebert
1 publication, 0.31%
|
|
The Royal Society
|
The Royal Society
1 publication, 0.31%
|
|
Spandidos Publications
|
Spandidos Publications
1 publication, 0.31%
|
|
Baishideng Publishing Group
|
Baishideng Publishing Group
1 publication, 0.31%
|
|
10
20
30
40
50
60
70
80
90
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[1998,1999,2000,2001,2002,2003,2004,2005,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","","","","","","","","","","","","","","","","","","","",""],"datasets":[{"label":"Citations number","data":[6,35,39,27,28,28,18,19,13,6,11,5,7,7,8,8,10,11,2,7,3,8,2,5,4,2,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["1.87","10.9","12.15","8.41","8.72","8.72","5.61","5.92","4.05","1.87","3.43","1.56","2.18","2.18","2.49","2.49","3.12","3.43","0.62","2.18","0.93","2.49","0.62","1.56","1.25","0.62","0.31"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Molecular and Cellular Biology","Journal of Biological Chemistry","Oncogene","Proceedings of the National Academy of Sciences of the United States of America","Genetics","Current Biology","Molecular Biology of the Cell","Molecular Cell","Biochemical and Biophysical Research Communications","Nucleic Acids Research","FEBS Letters","Journal of Cell Science","Nature","Nature Genetics","Science","Current Opinion in Genetics and Development","Experimental Cell Research","Current Opinion in Cell Biology","Cancer Letters","Cancer Cell","International Journal of Molecular Sciences","PLoS ONE","Blood","Genes and Development","Biochimie","Cell","Biochemical Pharmacology","Journal of Molecular and Cellular Cardiology","Trends in Biochemical Sciences"],"ids":[17678,19451,20423,306,10675,16010,18406,19820,12390,23904,405,21886,14611,5840,7711,11302,525,7206,1654,23070,14627,24963,6594,7332,4794,16552,20448,5720,4668],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/9EVpRifnnUJt6oHGY5GfsfSXTEz5wzbdgnZqiF5m_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/1pFWD0EzQnc5egizpglbyNDhAbHCAVj1O7hBchfP_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/ko5EaisKGm66J1hHXtfEgVEeeWb9uOcMofpNuf0a_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/QMhhcrIUiVtFnND3WWZ7hIbu6GYeoRoA2zoVsMEX_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[27,19,11,8,7,6,6,5,5,5,4,4,4,4,4,3,3,3,3,3,3,3,3,3,2,2,2,2,2],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[8.41,5.92,3.43,2.49,2.18,1.87,1.87,1.56,1.56,1.56,1.25,1.25,1.25,1.25,1.25,0.93,0.93,0.93,0.93,0.93,0.93,0.93,0.93,0.93,0.62,0.62,0.62,0.62,0.62],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Springer Nature","American Society for Microbiology","Wiley","American Society for Biochemistry and Molecular Biology","Proceedings of the National Academy of Sciences (PNAS)","Genetics Society of America","Wolters Kluwer Health","Multidisciplinary Digital Publishing Institute (MDPI)","Taylor & Francis","American Society for Cell Biology (ASCB)","Oxford University Press","The Company of Biologists","Public Library of Science (PLoS)","American Association for the Advancement of Science (AAAS)","Cold Spring Harbor Laboratory","Pleiades Publishing","American Chemical Society (ACS)","American Society of Hematology","American Association for Cancer Research (AACR)","American Thoracic Society","CSIRO Publishing","The Endocrine Society","Impact Journals","IOS Press","Mary Ann Liebert","The Royal Society","Spandidos Publications","Baishideng Publishing Group"],"ids":[17,8,142,11,2090,162,3356,32,202,18,4151,19,872,344,189,6909,101,40,2252,2286,3246,7016,2489,342,29,230,259,1097,7719],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/9EVpRifnnUJt6oHGY5GfsfSXTEz5wzbdgnZqiF5m_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/1pFWD0EzQnc5egizpglbyNDhAbHCAVj1O7hBchfP_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/ko5EaisKGm66J1hHXtfEgVEeeWb9uOcMofpNuf0a_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/QMhhcrIUiVtFnND3WWZ7hIbu6GYeoRoA2zoVsMEX_medium.webp","\/storage\/images\/resized\/cfuVw6XIq2mATDNJdXiose3W8qYbkmaVSpHoP8XL_medium.webp","\/storage\/images\/resized\/y6coX2RdMAMXy0PTXCMVDlJvumyjAcjbT7WXoxjx_medium.webp","\/storage\/images\/resized\/se1SPF1aqPN9oZ2Pvhp519I0unlLQM7LOKSeYPe8_medium.webp","\/storage\/images\/resized\/ykVNlEVbd1r3y7sMfZorOnDlpU1cRYn1ESbDmhRe_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/KqWdDIHwzps3KNMz2kSZBC4SgMnkL3bwEKJqtZ2u_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/BHBStD1OkQqtKFRRjS5njgNe7bXCAEgaDQVK7GTA_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/bKOjgSt9mSGUD9fzKZyqcKSIgDCDSMd1ZWjJOZzx_medium.webp"],"datasets":[{"label":"","data":[82,45,31,27,19,8,7,6,6,6,6,5,4,4,4,4,3,3,3,2,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[25.55,14.02,9.66,8.41,5.92,2.49,2.18,1.87,1.87,1.87,1.87,1.56,1.25,1.25,1.25,1.25,0.93,0.93,0.93,0.62,0.31,0.31,0.31,0.31,0.31,0.31,0.31,0.31,0.31],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Nugent C., Lundblad V. The telomerase reverse transcriptase: components and regulation // Genes and Development. 1998. Vol. 12. No. 8. pp. 1073-1085.
GOST all authors (up to 50)
Copy
Nugent C., Lundblad V. The telomerase reverse transcriptase: components and regulation // Genes and Development. 1998. Vol. 12. No. 8. pp. 1073-1085.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1101/gad.12.8.1073
UR - https://doi.org/10.1101%2Fgad.12.8.1073
TI - The telomerase reverse transcriptase: components and regulation
T2 - Genes and Development
AU - Nugent, Constance
AU - Lundblad, V.
PY - 1998
DA - 1998/04/15 00:00:00
PB - Cold Spring Harbor Laboratory
SP - 1073-1085
IS - 8
VL - 12
SN - 0890-9369
SN - 1549-5477
ER -
Cite this
BibTex
Copy
@article{1998_Nugent,
author = {Constance Nugent and V. Lundblad},
title = {The telomerase reverse transcriptase: components and regulation},
journal = {Genes and Development},
year = {1998},
volume = {12},
publisher = {Cold Spring Harbor Laboratory},
month = {apr},
url = {https://doi.org/10.1101%2Fgad.12.8.1073},
number = {8},
pages = {1073--1085},
doi = {10.1101/gad.12.8.1073}
}
Cite this
MLA
Copy
Nugent, Constance, and V. Lundblad. “The telomerase reverse transcriptase: components and regulation.” Genes and Development, vol. 12, no. 8, Apr. 1998, pp. 1073-1085. https://doi.org/10.1101%2Fgad.12.8.1073.