Open Access
Open access
Genes and Development, volume 29, issue 11, pages 1095-1105

Human telomerase: biogenesis, trafficking, recruitment, and activation

Schmidt Jens 1
Cech Thomas R. 1
1
 
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado 80309, USA
Publication typeJournal Article
Publication date2015-06-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor10.5
ISSN08909369, 15495477
Genetics
Developmental Biology
Abstract
Telomerase is the ribonucleoprotein enzyme that catalyzes the extension of telomeric DNA in eukaryotes. Recent work has begun to reveal key aspects of the assembly of the human telomerase complex, its intracellular trafficking involving Cajal bodies, and its recruitment to telomeres. Once telomerase has been recruited to the telomere, it appears to undergo a separate activation step, which may include an increase in its repeat addition processivity. This review covers human telomerase biogenesis, trafficking, and activation, comparing key aspects with the analogous events in other species.

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GOST |
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GOST Copy
Schmidt J., Cech T. R. Human telomerase: biogenesis, trafficking, recruitment, and activation // Genes and Development. 2015. Vol. 29. No. 11. pp. 1095-1105.
GOST all authors (up to 50) Copy
Schmidt J., Cech T. R. Human telomerase: biogenesis, trafficking, recruitment, and activation // Genes and Development. 2015. Vol. 29. No. 11. pp. 1095-1105.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1101/gad.263863.115
UR - https://doi.org/10.1101%2Fgad.263863.115
TI - Human telomerase: biogenesis, trafficking, recruitment, and activation
T2 - Genes and Development
AU - Schmidt, Jens
AU - Cech, Thomas R.
PY - 2015
DA - 2015/06/01 00:00:00
PB - Cold Spring Harbor Laboratory
SP - 1095-1105
IS - 11
VL - 29
PMID - 26063571
SN - 0890-9369
SN - 1549-5477
ER -
BibTex |
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BibTex Copy
@article{2015_Schmidt
author = {Jens Schmidt and Thomas R. Cech},
title = {Human telomerase: biogenesis, trafficking, recruitment, and activation},
journal = {Genes and Development},
year = {2015},
volume = {29},
publisher = {Cold Spring Harbor Laboratory},
month = {jun},
url = {https://doi.org/10.1101%2Fgad.263863.115},
number = {11},
pages = {1095--1105},
doi = {10.1101/gad.263863.115}
}
MLA
Cite this
MLA Copy
Schmidt, Jens, and Thomas R. Cech. “Human telomerase: biogenesis, trafficking, recruitment, and activation.” Genes and Development, vol. 29, no. 11, Jun. 2015, pp. 1095-1105. https://doi.org/10.1101%2Fgad.263863.115.
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