5-Arylaminouracil Derivatives: New Inhibitors ofMycobacterium tuberculosis
Elena Matyugina
1
,
Mikhail Novikov
2
,
Denis A Babkov
2
,
A.A. Ozerov
2
,
Larisa Chernousova
3
,
Sofia Andreevskaya
3
,
Tatiana Smirnova
3
,
И. Л. Карпенко
1
,
A. O. Chizhov
4
,
Pravin Murthu
5
,
Stefan Lutz
5
,
Sergei Kochetkov
1
,
Тип публикации: Journal Article
Дата публикации: 2015-07-14
scimago Q2
wos Q2
БС2
SJR: 0.689
CiteScore: 5.6
Impact factor: 3.3
ISSN: 17470277, 17470285
PubMed ID:
26061192
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
Краткое описание
Three series of 5‐arylaminouracil derivatives, including 5‐(phenylamino)uracils, 1‐(4′‐hydroxy‐2′‐cyclopenten‐1′‐yl)‐5‐(phenylamino)uracils, and 1,3‐di‐(4′‐hydroxy‐2′‐cyclopenten‐1′‐yl)‐5‐(phenylamino)uracils, were synthesized and screened for potential antimicrobial activity. Most of compounds had a negative effect on the growth of the Mycobacterium tuberculosis H37Rv strain, with 100% inhibition observed at concentrations between 5 and 40 μg/mL. Of those, 1‐(4′‐hydroxy‐2′‐cyclopenten‐1′‐yl)‐3‐(4‴‐hydroxy‐2‴‐cyclopenten‐1‴‐yl)‐5‐(4″‐butyloxyphenylamino)uracil proved to be the most active among tested compounds against the M. tuberculosis multidrug‐resistant strain MS‐115 (MIC90 5 μg/mL). In addition, the thymidylate kinase of M. tuberculosis was evaluated as a possible enzymatic target.
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Matyugina E. et al. 5-Arylaminouracil Derivatives: New Inhibitors ofMycobacterium tuberculosis // Chemical Biology and Drug Design. 2015. Vol. 86. No. 6. pp. 1387-1396.
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Matyugina E., Novikov M., Babkov D. A., Ozerov A., Chernousova L., Andreevskaya S., Smirnova T., Карпенко И. Л., Chizhov A. O., Murthu P., Lutz S., Kochetkov S., Seley-Radtke K. L., Khandazhinskaya A. 5-Arylaminouracil Derivatives: New Inhibitors ofMycobacterium tuberculosis // Chemical Biology and Drug Design. 2015. Vol. 86. No. 6. pp. 1387-1396.
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TY - JOUR
DO - 10.1111/cbdd.12603
UR - https://doi.org/10.1111/cbdd.12603
TI - 5-Arylaminouracil Derivatives: New Inhibitors ofMycobacterium tuberculosis
T2 - Chemical Biology and Drug Design
AU - Matyugina, Elena
AU - Novikov, Mikhail
AU - Babkov, Denis A
AU - Ozerov, A.A.
AU - Chernousova, Larisa
AU - Andreevskaya, Sofia
AU - Smirnova, Tatiana
AU - Карпенко, И. Л.
AU - Chizhov, A. O.
AU - Murthu, Pravin
AU - Lutz, Stefan
AU - Kochetkov, Sergei
AU - Seley-Radtke, Katherine L.
AU - Khandazhinskaya, Anastasia
PY - 2015
DA - 2015/07/14
PB - Wiley
SP - 1387-1396
IS - 6
VL - 86
PMID - 26061192
SN - 1747-0277
SN - 1747-0285
ER -
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@article{2015_Matyugina,
author = {Elena Matyugina and Mikhail Novikov and Denis A Babkov and A.A. Ozerov and Larisa Chernousova and Sofia Andreevskaya and Tatiana Smirnova and И. Л. Карпенко and A. O. Chizhov and Pravin Murthu and Stefan Lutz and Sergei Kochetkov and Katherine L. Seley-Radtke and Anastasia Khandazhinskaya},
title = {5-Arylaminouracil Derivatives: New Inhibitors ofMycobacterium tuberculosis},
journal = {Chemical Biology and Drug Design},
year = {2015},
volume = {86},
publisher = {Wiley},
month = {jul},
url = {https://doi.org/10.1111/cbdd.12603},
number = {6},
pages = {1387--1396},
doi = {10.1111/cbdd.12603}
}
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MLA
Скопировать
Matyugina, Elena, et al. “5-Arylaminouracil Derivatives: New Inhibitors ofMycobacterium tuberculosis.” Chemical Biology and Drug Design, vol. 86, no. 6, Jul. 2015, pp. 1387-1396. https://doi.org/10.1111/cbdd.12603.