FEBS Journal, volume 289, issue 18, pages 5697-5713

Dietary restriction modulates mitochondrial DNA damage and oxylipin profile in aged rats

Gureev Artem P ^{1, 2}

Andrianova Nadezda V ³

Pevzner Irina B. ^{3, 4}

Zorova Ljubava D ^{3, 4}

Chernyshova Ekaterina V ¹

Sadovnikova Irina S ¹

Chistyakov Dmitry A ³

Popkov Vasily A. ^{3, 4}

Semenovich Dmitry S ³

Babenko Valentina A. ^{3, 4}

Silachev Denis N ^{3, 4}

Зоров Д. Б. ^{3, 4}

Plotnikov Egor Yu ^{3, 4}

Popov V. N. ^{1, 2}

Hide authors affiliations Show authors affiliations: 4 affiliations

Department of Genetics, Cytology and Bioengineering Voronezh State University Voronezh Russia"> Department of Genetics, Cytology and Bioengineering Voronezh State University Voronezh Russia |

Laboratory of Metagenomics and Food Biotechnology Voronezh State University of Engineering Technology Voronezh Russia |

Belozersky Institute of Physico‐Chemical Biology Lomonosov Moscow State University Moscow Russia"> Belozersky Institute of Physico‐Chemical Biology Lomonosov Moscow State University Moscow Russia |

⁴

Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology Moscow Russia |

Publication type: Journal Article

Publication date: 2022-04-19

Wiley

Journal: FEBS Journal

Quartile SCImago

Quartile WOS

Impact factor: 5.4

ISSN: 1742464X, 14321033

DOI: 10.1111/febs.16451

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Biochemistry

Molecular Biology

Cell Biology

Abstract

Age-related impairment of coordination of the processes of maintaining mitochondrial homeostasis is associated with a decrease in the functionality of cells and leads to degenerative processes. Mitochondrial DNA (mtDNA) can be a marker of oxidative stress and tissue degeneration. However, the mechanism of accumulation of age-related damage in mtDNA remains unclear. In this study, we analyzed the accumulation of mtDNA damage in several organs of rats during aging, as well as the possibility of reversing these alterations by dietary restriction (DR). We showed that mtDNA of brain compartments (with the exception of the cerebellum), along with kidney mtDNA, was the most susceptible to accumulation of age-related damage, while liver, testis, and lung were the least susceptible organs. DR prevented age-related accumulation of mtDNA damage in the cortex and led to its decrease in the lung and testis. Changes in mtDNA copy number and expression of genes involved in the regulation of mitochondrial biogenesis and mitophagy were also tissue-specific. There was a tendency for an age-related decrease in the copy number of mtDNA in the striatum and its increase in the kidney. DR promoted an increase in the amount of mtDNA in the cerebellum and hippocampus. mtDNA damage may be associated not only with the metabolic activity of organs but also with the lipid composition and activity of processes associated with the isoprostanes pathway of lipid peroxidation. The comparison of polyunsaturated fatty acids (PUFAs) and oxylipins profiles in old rats showed that DR decreased the synthesis of arachidonic acid and its metabolites synthesized by the cyclooxygenase (COX), cytochrome P450 monooxygenases (CYP), and lipoxygenase (LOX) metabolic pathways.

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Citations by journals

	1
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 25% International Journal of Molecular Sciences 1 publication, 25%
Biochemistry (Moscow)	Biochemistry (Moscow), 1, 25% Biochemistry (Moscow) 1 publication, 25%
Bulletin of Experimental Biology and Medicine	Bulletin of Experimental Biology and Medicine, 1, 25% Bulletin of Experimental Biology and Medicine 1 publication, 25%
Journal of Ethnopharmacology	Journal of Ethnopharmacology, 1, 25% Journal of Ethnopharmacology 1 publication, 25%
	1

Citations by publishers

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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 25% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 25%
Pleiades Publishing	Pleiades Publishing, 1, 25% Pleiades Publishing 1 publication, 25%
Springer Nature	Springer Nature, 1, 25% Springer Nature 1 publication, 25%
Elsevier	Elsevier, 1, 25% Elsevier 1 publication, 25%
	1

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Gureev A. P. et al. Dietary restriction modulates mitochondrial DNA damage and oxylipin profile in aged rats // FEBS Journal. 2022. Vol. 289. No. 18. pp. 5697-5713.

GOST all authors (up to 50) Copy

Gureev A. P., Andrianova N. V., Pevzner I. B., Zorova L. D., Chernyshova E. V., Sadovnikova I. S., Chistyakov D. A., Popkov V. A., Semenovich D. S., Babenko V. A., Silachev D. N., Зоров Д. Б., Plotnikov E. Yu., Popov V. N. Dietary restriction modulates mitochondrial DNA damage and oxylipin profile in aged rats // FEBS Journal. 2022. Vol. 289. No. 18. pp. 5697-5713.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1111/febs.16451

UR - https://doi.org/10.1111%2Ffebs.16451

TI - Dietary restriction modulates mitochondrial DNA damage and oxylipin profile in aged rats

T2 - FEBS Journal

AU - Chernyshova, Ekaterina V

AU - Sadovnikova, Irina S

AU - Babenko, Valentina A.

AU - Gureev, Artem P

AU - Andrianova, Nadezda V

AU - Pevzner, Irina B.

AU - Zorova, Ljubava D

AU - Chistyakov, Dmitry A

AU - Popkov, Vasily A.

AU - Semenovich, Dmitry S

AU - Silachev, Denis N

AU - Зоров, Д. Б.

AU - Plotnikov, Egor Yu

AU - Popov, V. N.

PY - 2022

DA - 2022/04/19 00:00:00

PB - Wiley

SP - 5697-5713

IS - 18

VL - 289

SN - 1742-464X

SN - 1432-1033

ER -

BibTex |

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BibTex Copy

@article{2022_Gureev,

author = {Ekaterina V Chernyshova and Irina S Sadovnikova and Valentina A. Babenko and Artem P Gureev and Nadezda V Andrianova and Irina B. Pevzner and Ljubava D Zorova and Dmitry A Chistyakov and Vasily A. Popkov and Dmitry S Semenovich and Denis N Silachev and Д. Б. Зоров and Egor Yu Plotnikov and V. N. Popov},

title = {Dietary restriction modulates mitochondrial DNA damage and oxylipin profile in aged rats},

journal = {FEBS Journal},

year = {2022},

volume = {289},

publisher = {Wiley},

month = {apr},

url = {https://doi.org/10.1111%2Ffebs.16451},

number = {18},

pages = {5697--5713},

doi = {10.1111/febs.16451}

}

MLA

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MLA Copy

Gureev, Artem P., et al. “Dietary restriction modulates mitochondrial DNA damage and oxylipin profile in aged rats.” FEBS Journal, vol. 289, no. 18, Apr. 2022, pp. 5697-5713. https://doi.org/10.1111%2Ffebs.16451.

Found error?

Publisher

Wiley

Journal

FEBS Journal

Quartile SCImago

Quartile WOS

Impact factor

5.4

ISSN

1742464X (Print)
14321033 (Electronic)

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