Journal of Pharmacy and Pharmacology, volume 70, issue 9, pages 1164-1173
A novel formulation of zolpidem for direct nose‐to‐brain delivery: synthesis, encapsulation and intranasal administration to mice
Borodina T N
1, 2
,
Marchenko Irina
1, 3
,
Trushina Daria
1, 2, 3
,
Volkova Yulia
4
,
Shirinian Valerii
4
,
Zavarzin Igor
4
,
Kondrakhin Evgeny
5
,
Kovalev Georgy
5
,
Kovalchuk Mikhail
1, 3
,
Bukreeva Tatiana
1, 3
1
Publication type: Journal Article
Publication date: 2018-06-28
Journal:
Journal of Pharmacy and Pharmacology
Quartile SCImago
Q1
Quartile WOS
Q3
Impact factor: 3.3
ISSN: 00223573, 20427158, 23282150, 23282150
Pharmacology
Pharmaceutical Science
Abstract
Objectives
Anxiolytic drug zolpidem was incorporated into the microcontainers based on mesoporous calcium carbonate particles modified by diethylaminoethyl-dextran/hyaluronic acid shell. The release of zolpidem in saline solution and in polymer film modelling nasal mucosa was investigated. The anxiolytic effect of zolpidem upon intranasal administration of microcontainers and free medicine was determined by in vivo experiments on mice.
Methods
The structures of all compounds during zolpidem synthesis were established using nuclear magnetic resonance spectroscopy. The loading efficacy and release kinetics of zolpidem were analysed by spectrophotometry. Surface morphology of formulation was investigated by scanning electron microscopy. To determine the effect of zolpidem-loaded containers administration by the intranasal route in vivo experiments was carried out applying the open field test.
Key findings
Nasal administration of zolpidem in the form of the microcontainers based on mesoporous calcium carbonate particles modified by diethylaminoethyl-dextran/hyaluronic acid shell has a pronounced anxiolytic effect on the behaviour of the animals in the open field test.
Conclusions
The polyelectrolyte shell deposited together with zolpidem enhances the loading efficacy of the microcontainers. In vivo experiments on mice demonstrate increase in anxiolytic effect of zolpidem in microcontainers compared with upon intranasal administration of free medicine.
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1 publication, 9.09%
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Herald of the Russian Academy of Sciences
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1 publication, 9.09%
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Citations by publishers
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Pleiades Publishing
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3 publications, 27.27%
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3 publications, 27.27%
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Elsevier
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2 publications, 18.18%
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Taylor & Francis
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1 publication, 9.09%
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Springer Nature
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Springer Nature
1 publication, 9.09%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 9.09%
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1
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Borodina T. N. et al. A novel formulation of zolpidem for direct nose‐to‐brain delivery: synthesis, encapsulation and intranasal administration to mice // Journal of Pharmacy and Pharmacology. 2018. Vol. 70. No. 9. pp. 1164-1173.
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Borodina T. N., Marchenko I., Trushina D., Volkova Y., Shirinian V., Zavarzin I., Kondrakhin E., Kovalev G., Kovalchuk M., Bukreeva T. A novel formulation of zolpidem for direct nose‐to‐brain delivery: synthesis, encapsulation and intranasal administration to mice // Journal of Pharmacy and Pharmacology. 2018. Vol. 70. No. 9. pp. 1164-1173.
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TY - JOUR
DO - 10.1111/jphp.12958
UR - https://doi.org/10.1111%2Fjphp.12958
TI - A novel formulation of zolpidem for direct nose‐to‐brain delivery: synthesis, encapsulation and intranasal administration to mice
T2 - Journal of Pharmacy and Pharmacology
AU - Borodina, T N
AU - Marchenko, Irina
AU - Trushina, Daria
AU - Volkova, Yulia
AU - Shirinian, Valerii
AU - Kondrakhin, Evgeny
AU - Kovalev, Georgy
AU - Kovalchuk, Mikhail
AU - Zavarzin, Igor
AU - Bukreeva, Tatiana
PY - 2018
DA - 2018/06/28 00:00:00
PB - Wiley
SP - 1164-1173
IS - 9
VL - 70
SN - 0022-3573
SN - 2042-7158
SN - 2328-2150
SN - 2328-2150
ER -
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@article{2018_Borodina,
author = {T N Borodina and Irina Marchenko and Daria Trushina and Yulia Volkova and Valerii Shirinian and Evgeny Kondrakhin and Georgy Kovalev and Mikhail Kovalchuk and Igor Zavarzin and Tatiana Bukreeva},
title = {A novel formulation of zolpidem for direct nose‐to‐brain delivery: synthesis, encapsulation and intranasal administration to mice},
journal = {Journal of Pharmacy and Pharmacology},
year = {2018},
volume = {70},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1111%2Fjphp.12958},
number = {9},
pages = {1164--1173},
doi = {10.1111/jphp.12958}
}
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MLA
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Borodina, T. N., et al. “A novel formulation of zolpidem for direct nose‐to‐brain delivery: synthesis, encapsulation and intranasal administration to mice.” Journal of Pharmacy and Pharmacology, vol. 70, no. 9, Jun. 2018, pp. 1164-1173. https://doi.org/10.1111%2Fjphp.12958.