Open Access
Open access
Journal of Biomedical Optics, volume 22, issue 08, pages 1

Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus.

Sidorov Victor V. 3
Krupatkin Alexander I. 4
Makovik Irina N. 1
Zherebtsova Angelina I. 1
Doronin Alexander 5
Rafailov Ilya E. 7
Litvinova Karina 8
Publication typeJournal Article
Publication date2017-08-19
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor3.5
ISSN10833668, 15602281
Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Biomedical Engineering
Abstract
According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus. These patients were divided into two groups depending on the degree of complications. The control group consisted of 48 healthy volunteers. The local thermal stimulation was selected as a stimulus on the blood microcirculation system. The experimental studies have shown that diabetic patients have elevated values of normalized fluorescence amplitudes, as well as a lower perfusion response to local heating. In the group of people with diabetes with trophic ulcers, these parameters also significantly differ from the control and diabetes only groups. Thus, the intensity of skin fluorescence and level of tissue blood perfusion can act as markers for various degrees of complications from the beginning of diabetes to the formation of trophic ulcers.

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GOST |
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GOST Copy
Meglinski I. et al. Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus. // Journal of Biomedical Optics. 2017. Vol. 22. No. 08. p. 1.
GOST all authors (up to 50) Copy
Meglinski I., Zherebtsov E. A., Sidorov V. V., Krupatkin A. I., Makovik I. N., Zherebtsova A. I., Zharkikh E. V., Potapova E. V., Dunaev A. V., Doronin A., Bykov A. V., Rafailov I. E., Litvinova K., Socolovski S., Rafailov E. Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus. // Journal of Biomedical Optics. 2017. Vol. 22. No. 08. p. 1.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1117/1.JBO.22.8.085003
UR - https://doi.org/10.1117%2F1.JBO.22.8.085003
TI - Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus.
T2 - Journal of Biomedical Optics
AU - Meglinski, Igor
AU - Zherebtsov, Evgeny A.
AU - Sidorov, Victor V.
AU - Krupatkin, Alexander I.
AU - Makovik, Irina N.
AU - Zherebtsova, Angelina I.
AU - Zharkikh, Elena V.
AU - Potapova, Elena V.
AU - Dunaev, Andrey V.
AU - Doronin, Alexander
AU - Bykov, Alexander V.
AU - Rafailov, Ilya E.
AU - Litvinova, Karina
AU - Socolovski, Sergey
AU - Rafailov, Edik
PY - 2017
DA - 2017/08/19 00:00:00
PB - SPIE
SP - 1
IS - 08
VL - 22
SN - 1083-3668
SN - 1560-2281
ER -
BibTex |
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BibTex Copy
@article{2017_Meglinski,
author = {Igor Meglinski and Evgeny A. Zherebtsov and Victor V. Sidorov and Alexander I. Krupatkin and Irina N. Makovik and Angelina I. Zherebtsova and Elena V. Zharkikh and Elena V. Potapova and Andrey V. Dunaev and Alexander Doronin and Alexander V. Bykov and Ilya E. Rafailov and Karina Litvinova and Sergey Socolovski and Edik Rafailov},
title = {Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus.},
journal = {Journal of Biomedical Optics},
year = {2017},
volume = {22},
publisher = {SPIE},
month = {aug},
url = {https://doi.org/10.1117%2F1.JBO.22.8.085003},
number = {08},
pages = {1},
doi = {10.1117/1.JBO.22.8.085003}
}
MLA
Cite this
MLA Copy
Meglinski, Igor, et al. “Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus..” Journal of Biomedical Optics, vol. 22, no. 08, Aug. 2017, p. 1. https://doi.org/10.1117%2F1.JBO.22.8.085003.
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