Open Access

Antimicrobial Agents and Chemotherapy, volume 50, issue 7, pages 2500-2505

The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics

Long Katherine S ¹

Poehlsgaard Jacob ²

Kehrenberg Corinna ³

Schwarz Stefan ³

Vester Birte ²

Hide authors affiliations Show authors affiliations: 3 affiliations

Institute of Molecular Biology and Physiology, University of Copenhagen, Sølvgade 83 H, DK-1307 Copenhagen K |

Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark |

Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystrasse 10, 31535 Neustadt-Mariensee, Germany |

Publication type: Journal Article

Publication date: 2006-07-06

American Society for Microbiology

Journal: Antimicrobial Agents and Chemotherapy

Quartile SCImago

Quartile WOS

Impact factor: 4.9

ISSN: 00664804, 10986596

DOI: 10.1128/AAC.00131-06

Copy DOI

PubMed ID: 16801432

Pharmacology

Infectious Diseases

Pharmacology (medical)

Abstract

ABSTRACT A novel multidrug resistance phenotype mediated by the Cfr rRNA methyltransferase is observed in Staphylococcus aureus and Escherichia coli. The cfr gene has previously been identified as a phenicol and lincosamide resistance gene on plasmids isolated from Staphylococcus spp. of animal origin and recently shown to encode a methyltransferase that modifies 23S rRNA at A2503. Antimicrobial susceptibility testing shows that S. aureus and E. coli strains expressing the cfr gene exhibit elevated MICs to a number of chemically unrelated drugs. The phenotype is named PhLOPSA for resistance to the following drug classes: Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics. Each of these five drug classes contains important antimicrobial agents that are currently used in human and/or veterinary medicine. We find that binding of the PhLOPSA drugs, which bind to overlapping sites at the peptidyl transferase center that abut nucleotide A2503, is perturbed upon Cfr-mediated methylation. Decreased drug binding to Cfr-methylated ribosomes has been confirmed by footprinting analysis. No other rRNA methyltransferase is known to confer resistance to five chemically distinct classes of antimicrobials. In addition, the findings described in this study represent the first report of a gene conferring transferable resistance to pleuromutilins and oxazolidinones.

By date By citations

Citations by journals

	10 20 30 40 50 60
Antimicrobial Agents and Chemotherapy	Antimicrobial Agents and Chemotherapy, 59, 10.79% Antimicrobial Agents and Chemotherapy 59 publications, 10.79%
Journal of Antimicrobial Chemotherapy	Journal of Antimicrobial Chemotherapy, 49, 8.96% Journal of Antimicrobial Chemotherapy 49 publications, 8.96%
Antibiotics	Antibiotics, 17, 3.11% Antibiotics 17 publications, 3.11%
Frontiers in Microbiology	Frontiers in Microbiology, 16, 2.93% Frontiers in Microbiology 16 publications, 2.93%
Diagnostic Microbiology and Infectious Disease	Diagnostic Microbiology and Infectious Disease, 16, 2.93% Diagnostic Microbiology and Infectious Disease 16 publications, 2.93%
Journal of Global Antimicrobial Resistance	Journal of Global Antimicrobial Resistance, 14, 2.56% Journal of Global Antimicrobial Resistance 14 publications, 2.56%
Veterinary Microbiology	Veterinary Microbiology, 12, 2.19% Veterinary Microbiology 12 publications, 2.19%
Nucleic Acids Research	Nucleic Acids Research, 8, 1.46% Nucleic Acids Research 8 publications, 1.46%
PLoS ONE	PLoS ONE, 8, 1.46% PLoS ONE 8 publications, 1.46%
Clinical Microbiology and Infection	Clinical Microbiology and Infection, 7, 1.28% Clinical Microbiology and Infection 7 publications, 1.28%
International Journal of Medical Microbiology	International Journal of Medical Microbiology, 7, 1.28% International Journal of Medical Microbiology 7 publications, 1.28%
Microbiology spectrum	Microbiology spectrum, 6, 1.1% Microbiology spectrum 6 publications, 1.1%
Expert Review of Anti-Infective Therapy	Expert Review of Anti-Infective Therapy, 6, 1.1% Expert Review of Anti-Infective Therapy 6 publications, 1.1%
Future Microbiology	Future Microbiology, 5, 0.91% Future Microbiology 5 publications, 0.91%
Microorganisms	Microorganisms, 5, 0.91% Microorganisms 5 publications, 0.91%
International Journal of Antimicrobial Agents	International Journal of Antimicrobial Agents, 5, 0.91% International Journal of Antimicrobial Agents 5 publications, 0.91%
EFSA Journal	EFSA Journal, 5, 0.91% EFSA Journal 5 publications, 0.91%
Science	Science, 5, 0.91% Science 5 publications, 0.91%
Clinical Microbiology Reviews	Clinical Microbiology Reviews, 5, 0.91% Clinical Microbiology Reviews 5 publications, 0.91%
Scientific Reports	Scientific Reports, 4, 0.73% Scientific Reports 4 publications, 0.73%
European Journal of Clinical Microbiology and Infectious Diseases	European Journal of Clinical Microbiology and Infectious Diseases, 4, 0.73% European Journal of Clinical Microbiology and Infectious Diseases 4 publications, 0.73%
Journal of Biological Chemistry	Journal of Biological Chemistry, 4, 0.73% Journal of Biological Chemistry 4 publications, 0.73%
Molecular Microbiology	Molecular Microbiology, 4, 0.73% Molecular Microbiology 4 publications, 0.73%
Journal of the American Chemical Society	Journal of the American Chemical Society, 4, 0.73% Journal of the American Chemical Society 4 publications, 0.73%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 4, 0.73% Proceedings of the National Academy of Sciences of the United States of America 4 publications, 0.73%
Microbial Drug Resistance	Microbial Drug Resistance, 3, 0.55% Microbial Drug Resistance 3 publications, 0.55%
Journal of Medical Microbiology	Journal of Medical Microbiology, 3, 0.55% Journal of Medical Microbiology 3 publications, 0.55%
Microbiology	Microbiology, 3, 0.55% Microbiology 3 publications, 0.55%
Molecules	Molecules, 3, 0.55% Molecules 3 publications, 0.55%
	10 20 30 40 50 60

Citations by publishers

	20 40 60 80 100 120
Elsevier	Elsevier, 120, 21.94% Elsevier 120 publications, 21.94%
American Society for Microbiology	American Society for Microbiology, 83, 15.17% American Society for Microbiology 83 publications, 15.17%
Oxford University Press	Oxford University Press, 64, 11.7% Oxford University Press 64 publications, 11.7%
Springer Nature	Springer Nature, 45, 8.23% Springer Nature 45 publications, 8.23%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 36, 6.58% Multidisciplinary Digital Publishing Institute (MDPI) 36 publications, 6.58%
Frontiers Media S.A.	Frontiers Media S.A., 22, 4.02% Frontiers Media S.A. 22 publications, 4.02%
Wiley	Wiley, 22, 4.02% Wiley 22 publications, 4.02%
Taylor & Francis	Taylor & Francis, 13, 2.38% Taylor & Francis 13 publications, 2.38%
American Chemical Society (ACS)	American Chemical Society (ACS), 12, 2.19% American Chemical Society (ACS) 12 publications, 2.19%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 9, 1.65% Public Library of Science (PLoS) 9 publications, 1.65%
Microbiology Society	Microbiology Society, 6, 1.1% Microbiology Society 6 publications, 1.1%
Future Medicine	Future Medicine, 5, 0.91% Future Medicine 5 publications, 0.91%
Mary Ann Liebert	Mary Ann Liebert, 5, 0.91% Mary Ann Liebert 5 publications, 0.91%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 5, 0.91% American Association for the Advancement of Science (AAAS) 5 publications, 0.91%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 4, 0.73% American Society for Biochemistry and Molecular Biology 4 publications, 0.73%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 4, 0.73% Proceedings of the National Academy of Sciences (PNAS) 4 publications, 0.73%
Bentham Science	Bentham Science, 3, 0.55% Bentham Science 3 publications, 0.55%
Wolters Kluwer Health	Wolters Kluwer Health, 3, 0.55% Wolters Kluwer Health 3 publications, 0.55%
SAGE	SAGE, 3, 0.55% SAGE 3 publications, 0.55%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 3, 0.55% Cold Spring Harbor Laboratory 3 publications, 0.55%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 0.37% Royal Society of Chemistry (RSC) 2 publications, 0.37%
Cambridge University Press	Cambridge University Press, 2, 0.37% Cambridge University Press 2 publications, 0.37%
Hindawi Limited	Hindawi Limited, 2, 0.37% Hindawi Limited 2 publications, 0.37%
Pleiades Publishing	Pleiades Publishing, 1, 0.18% Pleiades Publishing 1 publication, 0.18%
PeerJ	PeerJ, 1, 0.18% PeerJ 1 publication, 0.18%
American Society of Agronomy	American Society of Agronomy, 1, 0.18% American Society of Agronomy 1 publication, 0.18%
Kowsar Publishing Company	Kowsar Publishing Company, 1, 0.18% Kowsar Publishing Company 1 publication, 0.18%
Walter de Gruyter	Walter de Gruyter, 1, 0.18% Walter de Gruyter 1 publication, 0.18%
Pan American Health Organization/Organizacion Panamericana de la Salud	Pan American Health Organization/Organizacion Panamericana de la Salud, 1, 0.18% Pan American Health Organization/Organizacion Panamericana de la Salud 1 publication, 0.18%
	20 40 60 80 100 120

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Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
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Long K. S. et al. The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics // Antimicrobial Agents and Chemotherapy. 2006. Vol. 50. No. 7. pp. 2500-2505.

GOST all authors (up to 50) Copy

Long K. S., Poehlsgaard J., Kehrenberg C., Schwarz S., Vester B. The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics // Antimicrobial Agents and Chemotherapy. 2006. Vol. 50. No. 7. pp. 2500-2505.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1128/AAC.00131-06

UR - https://doi.org/10.1128%2FAAC.00131-06

TI - The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics

T2 - Antimicrobial Agents and Chemotherapy

AU - Long, Katherine S

AU - Poehlsgaard, Jacob

AU - Kehrenberg, Corinna

AU - Schwarz, Stefan

AU - Vester, Birte

PY - 2006

DA - 2006/07/06 00:00:00

PB - American Society for Microbiology

SP - 2500-2505

IS - 7

VL - 50

PMID - 16801432

SN - 0066-4804

SN - 1098-6596

ER -

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@article{2006_Long,

author = {Katherine S Long and Jacob Poehlsgaard and Corinna Kehrenberg and Stefan Schwarz and Birte Vester},

title = {The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics},

journal = {Antimicrobial Agents and Chemotherapy},

year = {2006},

volume = {50},

publisher = {American Society for Microbiology},

month = {jul},

url = {https://doi.org/10.1128%2FAAC.00131-06},

number = {7},

pages = {2500--2505},

doi = {10.1128/AAC.00131-06}

}

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Long, Katherine S., et al. “The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics.” Antimicrobial Agents and Chemotherapy, vol. 50, no. 7, Jul. 2006, pp. 2500-2505. https://doi.org/10.1128%2FAAC.00131-06.

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Publisher

American Society for Microbiology

Journal

Antimicrobial Agents and Chemotherapy

Quartile SCImago

Quartile WOS

Impact factor

4.9

ISSN

00664804 (Print)
10986596 (Electronic)