Biochemistry (Moscow), volume 81, issue 10, pages 1163-1172
New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel
Tereshchenkov A G
1
,
Shishkina A.V.
2
,
Karpenko V V
1
,
Chertkov V A
1
,
Konevega A L
3, 4
,
Kasatsky P S
3, 4
,
Bogdanov A. A.
1, 2
,
Sumbatyan N V
1
2
3
Publication type: Journal Article
Publication date: 2016-10-18
Journal:
Biochemistry (Moscow)
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.8
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Abstract
Novel fluorescent derivatives of macrolide antibiotics related to tylosin bearing rhodamine, fluorescein, Alexa Fluor 488, BODIPY FL, and nitrobenzoxadiazole (NBD) residues were synthesized. The formation of complexes of these compounds with 70S E. coli ribosomes was studied by measuring the fluorescence polarization depending on the ribosome amount at constant concentration of the fluorescent substance. With the synthesized fluorescent tylosin derivatives, the dissociation constants for ribosome complexes with several known antibiotics and macrolide analogs previously obtained were determined. It was found that the fluorescent tylosin derivatives containing BODIPY FL and NBD groups could be used to screen the binding of novel antibiotics to bacterial ribosomes in the macrolide-binding site.
Citations by journals
1
|
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RNA
|
RNA
1 publication, 10%
|
Journal of Molecular Biology
|
Journal of Molecular Biology
1 publication, 10%
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Antibiotics
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Antibiotics
1 publication, 10%
|
Biochemistry (Moscow)
|
Biochemistry (Moscow)
1 publication, 10%
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
1 publication, 10%
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Sensors
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Sensors
1 publication, 10%
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Microorganisms
|
Microorganisms
1 publication, 10%
|
Biomedicines
|
Biomedicines
1 publication, 10%
|
Methods in Enzymology
|
Methods in Enzymology
1 publication, 10%
|
Journal of Analytical Chemistry
|
Journal of Analytical Chemistry
1 publication, 10%
|
1
|
Citations by publishers
1
2
3
4
5
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
5 publications, 50%
|
Elsevier
|
Elsevier
2 publications, 20%
|
Pleiades Publishing
|
Pleiades Publishing
2 publications, 20%
|
Cold Spring Harbor Laboratory
|
Cold Spring Harbor Laboratory
1 publication, 10%
|
1
2
3
4
5
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Tereshchenkov A. G. et al. New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel // Biochemistry (Moscow). 2016. Vol. 81. No. 10. pp. 1163-1172.
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Tereshchenkov A. G., Shishkina A., Karpenko V. V., Chertkov V. A., Konevega A. L., Kasatsky P. S., Bogdanov A. A., Sumbatyan N. V. New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel // Biochemistry (Moscow). 2016. Vol. 81. No. 10. pp. 1163-1172.
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TY - JOUR
DO - 10.1134/S0006297916100138
UR - https://doi.org/10.1134%2FS0006297916100138
TI - New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel
T2 - Biochemistry (Moscow)
AU - Tereshchenkov, A G
AU - Shishkina, A.V.
AU - Karpenko, V V
AU - Chertkov, V A
AU - Konevega, A L
AU - Kasatsky, P S
AU - Bogdanov, A. A.
AU - Sumbatyan, N V
PY - 2016
DA - 2016/10/18 00:00:00
PB - Pleiades Publishing
SP - 1163-1172
IS - 10
VL - 81
SN - 0006-2979
SN - 1608-3040
ER -
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@article{2016_Tereshchenkov
author = {A G Tereshchenkov and A.V. Shishkina and V V Karpenko and V A Chertkov and A L Konevega and P S Kasatsky and A. A. Bogdanov and N V Sumbatyan},
title = {New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel},
journal = {Biochemistry (Moscow)},
year = {2016},
volume = {81},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://doi.org/10.1134%2FS0006297916100138},
number = {10},
pages = {1163--1172},
doi = {10.1134/S0006297916100138}
}
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MLA
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Tereshchenkov, A. G., et al. “New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel.” Biochemistry (Moscow), vol. 81, no. 10, Oct. 2016, pp. 1163-1172. https://doi.org/10.1134%2FS0006297916100138.