Biochemistry (Moscow), volume 81, issue 10, pages 1163-1172

New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel

Tereshchenkov A G 1
Shishkina A.V. 2
Karpenko V V 1
Chertkov V A 1
Konevega A L 3, 4
Kasatsky P S 3, 4
Bogdanov A. A. 1, 2
Sumbatyan N V 1
Publication typeJournal Article
Publication date2016-10-18
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor2.8
ISSN00062979, 16083040
Biochemistry
General Medicine
Abstract
Novel fluorescent derivatives of macrolide antibiotics related to tylosin bearing rhodamine, fluorescein, Alexa Fluor 488, BODIPY FL, and nitrobenzoxadiazole (NBD) residues were synthesized. The formation of complexes of these compounds with 70S E. coli ribosomes was studied by measuring the fluorescence polarization depending on the ribosome amount at constant concentration of the fluorescent substance. With the synthesized fluorescent tylosin derivatives, the dissociation constants for ribosome complexes with several known antibiotics and macrolide analogs previously obtained were determined. It was found that the fluorescent tylosin derivatives containing BODIPY FL and NBD groups could be used to screen the binding of novel antibiotics to bacterial ribosomes in the macrolide-binding site.

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GOST Copy
Tereshchenkov A. G. et al. New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel // Biochemistry (Moscow). 2016. Vol. 81. No. 10. pp. 1163-1172.
GOST all authors (up to 50) Copy
Tereshchenkov A. G., Shishkina A., Karpenko V. V., Chertkov V. A., Konevega A. L., Kasatsky P. S., Bogdanov A. A., Sumbatyan N. V. New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel // Biochemistry (Moscow). 2016. Vol. 81. No. 10. pp. 1163-1172.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1134/S0006297916100138
UR - https://doi.org/10.1134%2FS0006297916100138
TI - New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel
T2 - Biochemistry (Moscow)
AU - Tereshchenkov, A G
AU - Shishkina, A.V.
AU - Karpenko, V V
AU - Chertkov, V A
AU - Konevega, A L
AU - Kasatsky, P S
AU - Bogdanov, A. A.
AU - Sumbatyan, N V
PY - 2016
DA - 2016/10/18 00:00:00
PB - Pleiades Publishing
SP - 1163-1172
IS - 10
VL - 81
SN - 0006-2979
SN - 1608-3040
ER -
BibTex |
Cite this
BibTex Copy
@article{2016_Tereshchenkov
author = {A G Tereshchenkov and A.V. Shishkina and V V Karpenko and V A Chertkov and A L Konevega and P S Kasatsky and A. A. Bogdanov and N V Sumbatyan},
title = {New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel},
journal = {Biochemistry (Moscow)},
year = {2016},
volume = {81},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://doi.org/10.1134%2FS0006297916100138},
number = {10},
pages = {1163--1172},
doi = {10.1134/S0006297916100138}
}
MLA
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MLA Copy
Tereshchenkov, A. G., et al. “New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel.” Biochemistry (Moscow), vol. 81, no. 10, Oct. 2016, pp. 1163-1172. https://doi.org/10.1134%2FS0006297916100138.
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