Biochemistry (Moscow), volume 87, issue 9, pages 871-889
Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome
Khairullina Zimfira Z
1
,
Makarov Gennady I
2
,
Tereshchenkov Andrey G
3
,
Buev Vitaly S
4
,
Lukianov Dmitrii A.
1, 5
,
Tashlitsky Vadim N
1
,
Osterman Ilya A.
1, 5
,
Sumbatyan Natalia V
1
3
Publication type: Journal Article
Publication date: 2022-09-15
Journal:
Biochemistry (Moscow)
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.8
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Biophysics
Geriatrics and Gerontology
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Abstract
Design and synthesis of conjugates consisting of the macrolide antibiotic desmycosin and fragments of the antibacterial peptide oncocin were performed in attempt to develop new antimicrobial compounds. New compounds were shown to bind to the E. coli 70S ribosomes, to inhibit bacterial protein synthesis in vitro, as well as to suppress bacterial growth. The conjugates of N-terminal hexa- and tripeptide fragments of oncocin and 3,2′,4′′-triacetyldesmycosin were found to be active against some strains of macrolide-resistant bacteria. By simulating molecular dynamics of the complexes of these compounds with the wild-type bacterial ribosomes and with ribosomes, containing A2059G 23S RNA mutation, the specific structural features of their interactions were revealed.
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International Journal of Pharmaceutics
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International Journal of Pharmaceutics
1 publication, 100%
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Elsevier
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Elsevier
1 publication, 100%
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Khairullina Z. Z. et al. Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome // Biochemistry (Moscow). 2022. Vol. 87. No. 9. pp. 871-889.
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Khairullina Z. Z., Makarov G. I., Tereshchenkov A. G., Buev V. S., Lukianov D. A., Polshakov V. I., Tashlitsky V. N., Osterman I. A., Sumbatyan N. V. Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome // Biochemistry (Moscow). 2022. Vol. 87. No. 9. pp. 871-889.
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TY - JOUR
DO - 10.1134/S0006297922090024
UR - https://doi.org/10.1134%2FS0006297922090024
TI - Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome
T2 - Biochemistry (Moscow)
AU - Khairullina, Zimfira Z
AU - Makarov, Gennady I
AU - Tereshchenkov, Andrey G
AU - Buev, Vitaly S
AU - Lukianov, Dmitrii A.
AU - Polshakov, Vladimir I
AU - Tashlitsky, Vadim N
AU - Osterman, Ilya A.
AU - Sumbatyan, Natalia V
PY - 2022
DA - 2022/09/15 00:00:00
PB - Pleiades Publishing
SP - 871-889
IS - 9
VL - 87
SN - 0006-2979
SN - 1608-3040
ER -
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@article{2022_Khairullina,
author = {Zimfira Z Khairullina and Gennady I Makarov and Andrey G Tereshchenkov and Vitaly S Buev and Dmitrii A. Lukianov and Vladimir I Polshakov and Vadim N Tashlitsky and Ilya A. Osterman and Natalia V Sumbatyan},
title = {Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome},
journal = {Biochemistry (Moscow)},
year = {2022},
volume = {87},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134%2FS0006297922090024},
number = {9},
pages = {871--889},
doi = {10.1134/S0006297922090024}
}
Cite this
MLA
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Khairullina, Zimfira Z., et al. “Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome.” Biochemistry (Moscow), vol. 87, no. 9, Sep. 2022, pp. 871-889. https://doi.org/10.1134%2FS0006297922090024.