Open Access

Annual Review of Biochemistry, volume 87, issue 1, pages 451-478

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

Lin Jinzhong ¹

Zhou Dejian ¹

Steitz Thomas A. ^{2, 3, 4}

Polikanov Yury S. ⁵

Gagnon Matthieu G ^{2, 4, 6}

Hide authors affiliations Show authors affiliations: 6 affiliations

State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; |

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA; |

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA |

⁴

Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06520, USA |

⁵

Department of Biological Sciences, and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60607, USA; |

⁶

Current affiliation: Department of Microbiology and Immunology, and Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, USA; |

Publication type: Journal Article

Publication date: 2018-06-20

Annual Reviews

Journal: Annual Review of Biochemistry

Quartile SCImago

Quartile WOS

Impact factor: 16.6

ISSN: 00664154, 15454509

DOI: 10.1146/annurev-biochem-062917-011942

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Biochemistry

Abstract

Genetic information is translated into proteins by the ribosome. Structural studies of the ribosome and of its complexes with factors and inhibitors have provided invaluable information on the mechanism of protein synthesis. Ribosome inhibitors are among the most successful antimicrobial drugs and constitute more than half of all medicines used to treat infections. However, bacterial infections are becoming increasingly difficult to treat because the microbes have developed resistance to the most effective antibiotics, creating a major public health care threat. This has spurred a renewed interest in structure-function studies of protein synthesis inhibitors, and in few cases, compounds have been developed into potent therapeutic agents against drug-resistant pathogens. In this review, we describe the modes of action of many ribosome-targeting antibiotics, highlight the major resistance mechanisms developed by pathogenic bacteria, and discuss recent advances in structure-assisted design of new molecules.

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Citations by journals

	1 2 3 4 5 6 7 8 9
Nucleic Acids Research	Nucleic Acids Research, 9, 4.66% Nucleic Acids Research 9 publications, 4.66%
Nature Communications	Nature Communications, 7, 3.63% Nature Communications 7 publications, 3.63%
Antibiotics	Antibiotics, 4, 2.07% Antibiotics 4 publications, 2.07%
Molecules	Molecules, 4, 2.07% Molecules 4 publications, 2.07%
Microorganisms	Microorganisms, 4, 2.07% Microorganisms 4 publications, 2.07%
Nature Chemical Biology	Nature Chemical Biology, 4, 2.07% Nature Chemical Biology 4 publications, 2.07%
mBio	mBio, 4, 2.07% mBio 4 publications, 2.07%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 1.55% International Journal of Molecular Sciences 3 publications, 1.55%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 3, 1.55% Proceedings of the National Academy of Sciences of the United States of America 3 publications, 1.55%
Antimicrobial Agents and Chemotherapy	Antimicrobial Agents and Chemotherapy, 2, 1.04% Antimicrobial Agents and Chemotherapy 2 publications, 1.04%
Biochimie	Biochimie, 2, 1.04% Biochimie 2 publications, 1.04%
Frontiers in Cellular and Infection Microbiology	Frontiers in Cellular and Infection Microbiology, 2, 1.04% Frontiers in Cellular and Infection Microbiology 2 publications, 1.04%
Cells	Cells, 2, 1.04% Cells 2 publications, 1.04%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 2, 1.04% Frontiers in Bioengineering and Biotechnology 2 publications, 1.04%
Frontiers in Microbiology	Frontiers in Microbiology, 2, 1.04% Frontiers in Microbiology 2 publications, 1.04%
Nature	Nature, 2, 1.04% Nature 2 publications, 1.04%
Current Microbiology	Current Microbiology, 2, 1.04% Current Microbiology 2 publications, 1.04%
Nature Chemistry	Nature Chemistry, 2, 1.04% Nature Chemistry 2 publications, 1.04%
Nature Structural and Molecular Biology	Nature Structural and Molecular Biology, 2, 1.04% Nature Structural and Molecular Biology 2 publications, 1.04%
Journal of Biological Chemistry	Journal of Biological Chemistry, 2, 1.04% Journal of Biological Chemistry 2 publications, 1.04%
ChemMedChem	ChemMedChem, 2, 1.04% ChemMedChem 2 publications, 1.04%
ACS Infectious Diseases	ACS Infectious Diseases, 2, 1.04% ACS Infectious Diseases 2 publications, 1.04%
ACS Chemical Biology	ACS Chemical Biology, 2, 1.04% ACS Chemical Biology 2 publications, 1.04%
Microbiology spectrum	Microbiology spectrum, 2, 1.04% Microbiology spectrum 2 publications, 1.04%
Natural Product Reports	Natural Product Reports, 2, 1.04% Natural Product Reports 2 publications, 1.04%
Critical Reviews in Microbiology	Critical Reviews in Microbiology, 2, 1.04% Critical Reviews in Microbiology 2 publications, 1.04%
Acta Naturae	Acta Naturae, 1, 0.52% Acta Naturae 1 publication, 0.52%
Biomolecules	Biomolecules, 1, 0.52% Biomolecules 1 publication, 0.52%
Molecular Pharmacology	Molecular Pharmacology, 1, 0.52% Molecular Pharmacology 1 publication, 0.52%
	1 2 3 4 5 6 7 8 9

Citations by publishers

	5 10 15 20 25 30 35
Springer Nature	Springer Nature, 32, 16.58% Springer Nature 32 publications, 16.58%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 23, 11.92% Multidisciplinary Digital Publishing Institute (MDPI) 23 publications, 11.92%
Elsevier	Elsevier, 21, 10.88% Elsevier 21 publications, 10.88%
Oxford University Press	Oxford University Press, 12, 6.22% Oxford University Press 12 publications, 6.22%
Wiley	Wiley, 12, 6.22% Wiley 12 publications, 6.22%
American Society for Microbiology	American Society for Microbiology, 10, 5.18% American Society for Microbiology 10 publications, 5.18%
Frontiers Media S.A.	Frontiers Media S.A., 8, 4.15% Frontiers Media S.A. 8 publications, 4.15%
American Chemical Society (ACS)	American Chemical Society (ACS), 8, 4.15% American Chemical Society (ACS) 8 publications, 4.15%
Taylor & Francis	Taylor & Francis, 5, 2.59% Taylor & Francis 5 publications, 2.59%
Annual Reviews	Annual Reviews, 3, 1.55% Annual Reviews 3 publications, 1.55%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 1.55% Royal Society of Chemistry (RSC) 3 publications, 1.55%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 3, 1.55% Proceedings of the National Academy of Sciences (PNAS) 3 publications, 1.55%
American Society for Pharmacology and Experimental Therapeutics	American Society for Pharmacology and Experimental Therapeutics, 2, 1.04% American Society for Pharmacology and Experimental Therapeutics 2 publications, 1.04%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 2, 1.04% American Society for Biochemistry and Molecular Biology 2 publications, 1.04%
Acta Naturae Ltd	Acta Naturae Ltd, 1, 0.52% Acta Naturae Ltd 1 publication, 0.52%
Bentham Science	Bentham Science, 1, 0.52% Bentham Science 1 publication, 0.52%
Mary Ann Liebert	Mary Ann Liebert, 1, 0.52% Mary Ann Liebert 1 publication, 0.52%
Microbiology Society	Microbiology Society, 1, 0.52% Microbiology Society 1 publication, 0.52%
The Royal Society	The Royal Society, 1, 0.52% The Royal Society 1 publication, 0.52%
Future Medicine	Future Medicine, 1, 0.52% Future Medicine 1 publication, 0.52%
Biophysical Society of Japan	Biophysical Society of Japan, 1, 0.52% Biophysical Society of Japan 1 publication, 0.52%
PeerJ	PeerJ, 1, 0.52% PeerJ 1 publication, 0.52%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 0.52% Public Library of Science (PLoS) 1 publication, 0.52%
Pleiades Publishing	Pleiades Publishing, 1, 0.52% Pleiades Publishing 1 publication, 0.52%
Hindawi Limited	Hindawi Limited, 1, 0.52% Hindawi Limited 1 publication, 0.52%
eLife Sciences Publications	eLife Sciences Publications, 1, 0.52% eLife Sciences Publications 1 publication, 0.52%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 0.52% Cold Spring Harbor Laboratory 1 publication, 0.52%
Belgorod National Research University	Belgorod National Research University, 1, 0.52% Belgorod National Research University 1 publication, 0.52%
Naukova Dumka	Naukova Dumka, 1, 0.52% Naukova Dumka 1 publication, 0.52%
	5 10 15 20 25 30 35

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Lin J. et al. Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design // Annual Review of Biochemistry. 2018. Vol. 87. No. 1. pp. 451-478.

GOST all authors (up to 50) Copy

Lin J., Zhou D., Steitz T. A., Polikanov Y. S., Gagnon M. G. Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design // Annual Review of Biochemistry. 2018. Vol. 87. No. 1. pp. 451-478.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1146/annurev-biochem-062917-011942

UR - https://doi.org/10.1146%2Fannurev-biochem-062917-011942

TI - Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

T2 - Annual Review of Biochemistry

AU - Lin, Jinzhong

AU - Zhou, Dejian

AU - Steitz, Thomas A.

AU - Polikanov, Yury S.

AU - Gagnon, Matthieu G

PY - 2018

DA - 2018/06/20 00:00:00

PB - Annual Reviews

SP - 451-478

IS - 1

VL - 87

SN - 0066-4154

SN - 1545-4509

ER -

BibTex |

Cite this

BibTex Copy

@article{2018_Lin,

author = {Jinzhong Lin and Dejian Zhou and Thomas A. Steitz and Yury S. Polikanov and Matthieu G Gagnon},

title = {Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design},

journal = {Annual Review of Biochemistry},

year = {2018},

volume = {87},

publisher = {Annual Reviews},

month = {jun},

url = {https://doi.org/10.1146%2Fannurev-biochem-062917-011942},

number = {1},

pages = {451--478},

doi = {10.1146/annurev-biochem-062917-011942}

}

MLA

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MLA Copy

Lin, Jinzhong, et al. “Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.” Annual Review of Biochemistry, vol. 87, no. 1, Jun. 2018, pp. 451-478. https://doi.org/10.1146%2Fannurev-biochem-062917-011942.

Found error?

Publisher

Annual Reviews

Journal

Annual Review of Biochemistry

Quartile SCImago

Quartile WOS

Impact factor

16.6

ISSN

00664154 (Print)
15454509 (Electronic)