Open Access
Annual Review of Biophysics, volume 46, issue 1, pages 199-225
Progress in Human andTetrahymenaTelomerase Structure Determination
1
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569;, ,
|
Publication type: Journal Article
Publication date: 2017-05-22
Journal:
Annual Review of Biophysics
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 12.4
ISSN: 1936122X, 19361238
PubMed ID:
28301767
Biochemistry
Cell Biology
Structural Biology
Biophysics
Bioengineering
Abstract
Telomerase is an RNA-protein complex that extends the 3' ends of linear chromosomes, using a unique telomerase reverse transcriptase (TERT) and template in the telomerase RNA (TR), thereby helping to maintain genome integrity. TR assembles with TERT and species-specific proteins, and telomerase function in vivo requires interaction with telomere-associated proteins. Over the past two decades, structures of domains of TR and TERT as well as other telomerase- and telomere-interacting proteins have provided insights into telomerase function. A recently reported 9-Å cryo-electron microscopy map of the Tetrahymena telomerase holoenzyme has provided a framework for understanding how TR, TERT, and other proteins from ciliate as well as vertebrate telomerase fit and function together as well as unexpected insight into telomerase interaction at telomeres. Here we review progress in understanding the structural basis of human and Tetrahymena telomerase activity, assembly, and interactions.
Citations by journals
|
1
2
3
|
|
|
Nucleic Acids Research
|
Nucleic Acids Research
3 publications, 8.11%
|
|
Nature
|
Nature
3 publications, 8.11%
|
|
Cells
|
Cells
2 publications, 5.41%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
2 publications, 5.41%
|
|
Current Opinion in Structural Biology
|
Current Opinion in Structural Biology
2 publications, 5.41%
|
|
Wiley interdisciplinary reviews. RNA
|
Wiley interdisciplinary reviews. RNA
2 publications, 5.41%
|
|
Essays in Biochemistry
|
Essays in Biochemistry
1 publication, 2.7%
|
|
Molecules
|
Molecules
1 publication, 2.7%
|
|
Biomolecules
|
Biomolecules
1 publication, 2.7%
|
|
Nature Structural and Molecular Biology
|
Nature Structural and Molecular Biology
1 publication, 2.7%
|
|
Cellular and Molecular Life Sciences
|
Cellular and Molecular Life Sciences
1 publication, 2.7%
|
|
Ageing Research Reviews
|
Ageing Research Reviews
1 publication, 2.7%
|
|
Bioorganic Chemistry
|
Bioorganic Chemistry
1 publication, 2.7%
|
|
Cell
|
Cell
1 publication, 2.7%
|
|
BioEssays
|
BioEssays
1 publication, 2.7%
|
|
Plants
|
Plants
1 publication, 2.7%
|
|
RNA Biology
|
RNA Biology
1 publication, 2.7%
|
|
Expert Review of Gastroenterology and Hepatology
|
Expert Review of Gastroenterology and Hepatology
1 publication, 2.7%
|
|
Proceedings of the National Academy of Sciences of the United States of America
|
Proceedings of the National Academy of Sciences of the United States of America
1 publication, 2.7%
|
|
Annual Review of Biophysics
|
Annual Review of Biophysics
1 publication, 2.7%
|
|
RNA
|
RNA
1 publication, 2.7%
|
|
Cold Spring Harbor perspectives in biology
|
Cold Spring Harbor perspectives in biology
1 publication, 2.7%
|
|
Advances in Experimental Medicine and Biology
|
Advances in Experimental Medicine and Biology
1 publication, 2.7%
|
|
Journal of Molecular Biology
|
Journal of Molecular Biology
1 publication, 2.7%
|
|
1
2
3
|
Citations by publishers
|
1
2
3
4
5
6
7
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
7 publications, 18.92%
|
|
Springer Nature
|
Springer Nature
6 publications, 16.22%
|
|
Elsevier
|
Elsevier
6 publications, 16.22%
|
|
Oxford University Press
|
Oxford University Press
3 publications, 8.11%
|
|
Wiley
|
Wiley
3 publications, 8.11%
|
|
Taylor & Francis
|
Taylor & Francis
2 publications, 5.41%
|
|
Cold Spring Harbor Laboratory
|
Cold Spring Harbor Laboratory
2 publications, 5.41%
|
|
Portland Press
|
Portland Press
1 publication, 2.7%
|
|
Proceedings of the National Academy of Sciences (PNAS)
|
Proceedings of the National Academy of Sciences (PNAS)
1 publication, 2.7%
|
|
Annual Reviews
|
Annual Reviews
1 publication, 2.7%
|
|
1
2
3
4
5
6
7
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2017,2018,2019,2020,2021,2022,2023],"ids":[0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0],"imageUrls":["","","","","","",""],"datasets":[{"label":"Citations number","data":[4,5,9,6,8,2,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["10.81","13.51","24.32","16.22","21.62","5.41","8.11"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Nucleic Acids Research","Nature","Cells","International Journal of Molecular Sciences","Current Opinion in Structural Biology","Wiley interdisciplinary reviews. RNA","Essays in Biochemistry","Molecules","Biomolecules","Nature Structural and Molecular Biology","Cellular and Molecular Life Sciences","Ageing Research Reviews","Bioorganic Chemistry","Cell","BioEssays","Plants","RNA Biology","Expert Review of Gastroenterology and Hepatology","Proceedings of the National Academy of Sciences of the United States of America","Annual Review of Biophysics","RNA","Cold Spring Harbor perspectives in biology","Advances in Experimental Medicine and Biology","Journal of Molecular Biology"],"ids":[23904,14611,25293,14627,13702,8123,7813,1770,13780,13408,5151,5462,4196,16552,11017,17251,7613,17356,306,15936,12892,21200,17590,19701],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/A7oGMwx1m3fFJlKJvQUVra8h0itmEa7JZW0q3Q0b_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[3,3,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[8.11,8.11,5.41,5.41,5.41,5.41,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7,2.7],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","Elsevier","Oxford University Press","Wiley","Taylor & Francis","Cold Spring Harbor Laboratory","Portland Press","Proceedings of the National Academy of Sciences (PNAS)","Annual Reviews"],"ids":[202,8,17,19,11,18,6909,801,162,6941],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/A7oGMwx1m3fFJlKJvQUVra8h0itmEa7JZW0q3Q0b_medium.webp"],"datasets":[{"label":"","data":[7,6,6,3,3,2,2,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[18.92,16.22,16.22,8.11,8.11,5.41,5.41,2.7,2.7,2.7],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Chan H., Wang Y., Feigon J. Progress in Human andTetrahymenaTelomerase Structure Determination // Annual Review of Biophysics. 2017. Vol. 46. No. 1. pp. 199-225.
GOST all authors (up to 50)
Copy
Chan H., Wang Y., Feigon J. Progress in Human andTetrahymenaTelomerase Structure Determination // Annual Review of Biophysics. 2017. Vol. 46. No. 1. pp. 199-225.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1146/annurev-biophys-062215-011140
UR - https://doi.org/10.1146%2Fannurev-biophys-062215-011140
TI - Progress in Human andTetrahymenaTelomerase Structure Determination
T2 - Annual Review of Biophysics
AU - Chan, Henry
AU - Wang, Yaqiang
AU - Feigon, Juli
PY - 2017
DA - 2017/05/22 00:00:00
PB - Annual Reviews
SP - 199-225
IS - 1
VL - 46
PMID - 28301767
SN - 1936-122X
SN - 1936-1238
ER -
Cite this
BibTex
Copy
@article{2017_Chan,
author = {Henry Chan and Yaqiang Wang and Juli Feigon},
title = {Progress in Human andTetrahymenaTelomerase Structure Determination},
journal = {Annual Review of Biophysics},
year = {2017},
volume = {46},
publisher = {Annual Reviews},
month = {may},
url = {https://doi.org/10.1146%2Fannurev-biophys-062215-011140},
number = {1},
pages = {199--225},
doi = {10.1146/annurev-biophys-062215-011140}
}
Cite this
MLA
Copy
Chan, Henry, et al. “Progress in Human andTetrahymenaTelomerase Structure Determination.” Annual Review of Biophysics, vol. 46, no. 1, May. 2017, pp. 199-225. https://doi.org/10.1146%2Fannurev-biophys-062215-011140.