Annual Review of Genetics, volume 52, issue 1, pages 223-247
Shelterin-Mediated Telomere Protection
1
Laboratory of Cell Biology and Genetics, Rockefeller University, New York, NY 10065, USA;
|
Publication type: Journal Article
Publication date: 2018-11-23
Journal:
Annual Review of Genetics
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 11.1
ISSN: 00664197, 15452948
Genetics
Abstract
For more than a decade, it has been known that mammalian cells use shelterin to protect chromosome ends. Much progress has been made on the mechanism by which shelterin prevents telomeres from inadvertently activating DNA damage signaling and double-strand break (DSB) repair pathways. Shelterin averts activation of three DNA damage response enzymes [the ataxia-telangiectasia-mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) kinases and poly(ADP-ribose) polymerase 1 (PARP1)], blocks three DSB repair pathways [classical nonhomologous end joining (c-NHEJ), alternative (alt)-NHEJ, and homology-directed repair (HDR)], and prevents hyper-resection at telomeres. For several of these functions, mechanistic insights have emerged. In addition, much has been learned about how shelterin maintains the telomeric 3' overhang, forms and protects the t-loop structure, and promotes replication through telomeres. These studies revealed that shelterin is compartmentalized, with individual subunits dedicated to distinct aspects of the end-protection problem. This review focuses on the current knowledge of shelterin-mediated telomere protection, highlights differences between human and mouse shelterin, and discusses some of the questions that remain.
Citations by journals
|
5
10
15
20
25
30
35
|
|
|
Nucleic Acids Research
|
Nucleic Acids Research
34 publications, 6.25%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
24 publications, 4.41%
|
|
Genes
|
Genes
18 publications, 3.31%
|
|
Nature Communications
|
Nature Communications
17 publications, 3.13%
|
|
eLife
|
eLife
13 publications, 2.39%
|
|
Frontiers in Cell and Developmental Biology
|
Frontiers in Cell and Developmental Biology
12 publications, 2.21%
|
|
Cancers
|
Cancers
12 publications, 2.21%
|
|
DNA Repair
|
DNA Repair
9 publications, 1.65%
|
|
Cells
|
Cells
8 publications, 1.47%
|
|
Journal of Molecular Biology
|
Journal of Molecular Biology
8 publications, 1.47%
|
|
Current Opinion in Genetics and Development
|
Current Opinion in Genetics and Development
8 publications, 1.47%
|
|
Communications Biology
|
Communications Biology
7 publications, 1.29%
|
|
Scientific Reports
|
Scientific Reports
7 publications, 1.29%
|
|
Cell Reports
|
Cell Reports
7 publications, 1.29%
|
|
Biomedicines
|
Biomedicines
6 publications, 1.1%
|
|
Nature Structural and Molecular Biology
|
Nature Structural and Molecular Biology
5 publications, 0.92%
|
|
Journal of Experimental and Clinical Cancer Research
|
Journal of Experimental and Clinical Cancer Research
5 publications, 0.92%
|
|
PLoS Genetics
|
PLoS Genetics
5 publications, 0.92%
|
|
Journal of Biological Chemistry
|
Journal of Biological Chemistry
5 publications, 0.92%
|
|
Genes and Development
|
Genes and Development
5 publications, 0.92%
|
|
Nature
|
Nature
4 publications, 0.74%
|
|
Aging Cell
|
Aging Cell
4 publications, 0.74%
|
|
Human Molecular Genetics
|
Human Molecular Genetics
4 publications, 0.74%
|
|
EMBO Journal
|
EMBO Journal
4 publications, 0.74%
|
|
Biogerontology
|
Biogerontology
4 publications, 0.74%
|
|
Cell
|
Cell
3 publications, 0.55%
|
|
Aging
|
Aging
3 publications, 0.55%
|
|
Biomolecules
|
Biomolecules
3 publications, 0.55%
|
|
Frontiers in Genetics
|
Frontiers in Genetics
3 publications, 0.55%
|
|
5
10
15
20
25
30
35
|
Citations by publishers
|
10
20
30
40
50
60
70
80
90
100
|
|
|
Elsevier
|
Elsevier
92 publications, 16.91%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
83 publications, 15.26%
|
|
Springer Nature
|
Springer Nature
77 publications, 14.15%
|
|
Oxford University Press
|
Oxford University Press
45 publications, 8.27%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
26 publications, 4.78%
|
|
Wiley
|
Wiley
22 publications, 4.04%
|
|
eLife Sciences Publications
|
eLife Sciences Publications
13 publications, 2.39%
|
|
EMBO press
|
EMBO press
9 publications, 1.65%
|
|
Cold Spring Harbor Laboratory
|
Cold Spring Harbor Laboratory
9 publications, 1.65%
|
|
Public Library of Science (PLoS)
|
Public Library of Science (PLoS)
7 publications, 1.29%
|
|
American Association for the Advancement of Science (AAAS)
|
American Association for the Advancement of Science (AAAS)
6 publications, 1.1%
|
|
Taylor & Francis
|
Taylor & Francis
6 publications, 1.1%
|
|
American Society for Biochemistry and Molecular Biology
|
American Society for Biochemistry and Molecular Biology
5 publications, 0.92%
|
|
Impact Journals
|
Impact Journals
4 publications, 0.74%
|
|
Genetics Society of America
|
Genetics Society of America
4 publications, 0.74%
|
|
Wolters Kluwer Health
|
Wolters Kluwer Health
3 publications, 0.55%
|
|
American Society of Hematology
|
American Society of Hematology
3 publications, 0.55%
|
|
Mary Ann Liebert
|
Mary Ann Liebert
2 publications, 0.37%
|
|
Portland Press
|
Portland Press
2 publications, 0.37%
|
|
Spandidos Publications
|
Spandidos Publications
2 publications, 0.37%
|
|
Federation of American Societies for Experimental Biology (FASEB)
|
Federation of American Societies for Experimental Biology (FASEB)
2 publications, 0.37%
|
|
Pleiades Publishing
|
Pleiades Publishing
2 publications, 0.37%
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
2 publications, 0.37%
|
|
American Society of Plant Biologists
|
American Society of Plant Biologists
2 publications, 0.37%
|
|
Rockefeller University Press
|
Rockefeller University Press
2 publications, 0.37%
|
|
Proceedings of the National Academy of Sciences (PNAS)
|
Proceedings of the National Academy of Sciences (PNAS)
2 publications, 0.37%
|
|
Annual Reviews
|
Annual Reviews
2 publications, 0.37%
|
|
Bentham Science
|
Bentham Science
1 publication, 0.18%
|
|
The Company of Biologists
|
The Company of Biologists
1 publication, 0.18%
|
|
10
20
30
40
50
60
70
80
90
100
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0],"imageUrls":["","","","","","",""],"datasets":[{"label":"Citations number","data":[2,53,99,126,108,123,33],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["0.37","9.74","18.2","23.16","19.85","22.61","6.07"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Nucleic Acids Research","International Journal of Molecular Sciences","Genes","Nature Communications","eLife","Frontiers in Cell and Developmental Biology","Cancers","DNA Repair","Cells","Journal of Molecular Biology","Current Opinion in Genetics and Development","Communications Biology","Scientific Reports","Cell Reports","Biomedicines","Nature Structural and Molecular Biology","Journal of Experimental and Clinical Cancer Research","PLoS Genetics","Journal of Biological Chemistry","Genes and Development","Nature","Aging Cell","Human Molecular Genetics","EMBO Journal","Biogerontology","Cell","Aging","Biomolecules","Frontiers in Genetics"],"ids":[23904,14627,8879,3231,24138,12128,22471,13424,25293,19701,11302,11778,13767,9130,24421,13408,5741,785,19451,7332,14611,17299,4947,16016,7607,16552,780,13780,13242],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/eIZgkq1MRZyJ3hBkdupnUUv7wgB6zCl9D99SlPN5_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/1UiI5HycPsvulDeXOySNp0OuaMMmIKfPnsdKPyH0_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp"],"datasets":[{"label":"","data":[34,24,18,17,13,12,12,9,8,8,8,7,7,7,6,5,5,5,5,5,4,4,4,4,4,3,3,3,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[6.25,4.41,3.31,3.13,2.39,2.21,2.21,1.65,1.47,1.47,1.47,1.29,1.29,1.29,1.1,0.92,0.92,0.92,0.92,0.92,0.74,0.74,0.74,0.74,0.74,0.55,0.55,0.55,0.55],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","Oxford University Press","Frontiers Media S.A.","Wiley","eLife Sciences Publications","EMBO press","Cold Spring Harbor Laboratory","Public Library of Science (PLoS)","American Association for the Advancement of Science (AAAS)","Taylor & Francis","American Society for Biochemistry and Molecular Biology","Impact Journals","Genetics Society of America","Wolters Kluwer Health","American Society of Hematology","Mary Ann Liebert","Portland Press","Spandidos Publications","Federation of American Societies for Experimental Biology (FASEB)","Pleiades Publishing","American Chemical Society (ACS)","American Society of Plant Biologists","Rockefeller University Press","Proceedings of the National Academy of Sciences (PNAS)","Annual Reviews","Bentham Science","The Company of Biologists"],"ids":[17,202,8,19,208,11,6627,9415,6909,344,189,18,2090,342,3356,32,2252,230,801,1097,3243,101,40,2122,22,162,6941,39,872],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/eIZgkq1MRZyJ3hBkdupnUUv7wgB6zCl9D99SlPN5_medium.webp","\/storage\/images\/resized\/1UiI5HycPsvulDeXOySNp0OuaMMmIKfPnsdKPyH0_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/OuA6WPZekwEiUM99mP2pSqj4yHPxHezM6xgLhAjO_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/9EVpRifnnUJt6oHGY5GfsfSXTEz5wzbdgnZqiF5m_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/QMhhcrIUiVtFnND3WWZ7hIbu6GYeoRoA2zoVsMEX_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/dfTCxFYwjmdhSAwAcIOV9PfBdAN17zTMvybxH2kG_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/JLpI53lI44aNyHLD8xZshTDqAobKeIZXi5qWe93H_medium.webp","\/storage\/images\/resized\/lEA1FyUnFAZR1DchuczZi5bjAixG3TNeWVz6oF4R_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/A7oGMwx1m3fFJlKJvQUVra8h0itmEa7JZW0q3Q0b_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/ko5EaisKGm66J1hHXtfEgVEeeWb9uOcMofpNuf0a_medium.webp"],"datasets":[{"label":"","data":[92,83,77,45,26,22,13,9,9,7,6,6,5,4,4,3,3,2,2,2,2,2,2,2,2,2,2,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[16.91,15.26,14.15,8.27,4.78,4.04,2.39,1.65,1.65,1.29,1.1,1.1,0.92,0.74,0.74,0.55,0.55,0.37,0.37,0.37,0.37,0.37,0.37,0.37,0.37,0.37,0.37,0.18,0.18],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
RIS
Copy
TY - JOUR
DO - 10.1146/annurev-genet-032918-021921
UR - https://doi.org/10.1146%2Fannurev-genet-032918-021921
TI - Shelterin-Mediated Telomere Protection
T2 - Annual Review of Genetics
AU - de Lange, Titia
PY - 2018
DA - 2018/11/23 00:00:00
PB - Annual Reviews
SP - 223-247
IS - 1
VL - 52
SN - 0066-4197
SN - 1545-2948
ER -
Cite this
BibTex
Copy
@article{2018_de Lange,
author = {Titia de Lange},
title = {Shelterin-Mediated Telomere Protection},
journal = {Annual Review of Genetics},
year = {2018},
volume = {52},
publisher = {Annual Reviews},
month = {nov},
url = {https://doi.org/10.1146%2Fannurev-genet-032918-021921},
number = {1},
pages = {223--247},
doi = {10.1146/annurev-genet-032918-021921}
}
Cite this
MLA
Copy
de Lange, Titia. “Shelterin-Mediated Telomere Protection.” Annual Review of Genetics, vol. 52, no. 1, Nov. 2018, pp. 223-247. https://doi.org/10.1146%2Fannurev-genet-032918-021921.