A Critical and Comparative Review of Fluorescent Tools for Live-Cell Imaging
Fluorescent tools have revolutionized our ability to probe biological dynamics, particularly at the cellular level. Fluorescent sensors have been developed on several platforms, utilizing either small-molecule dyes or fluorescent proteins, to monitor proteins, RNA, DNA, small molecules, and even cellular properties, such as pH and membrane potential. We briefly summarize the impressive history of tool development for these various applications and then discuss the most recent noteworthy developments in more detail. Particular emphasis is placed on tools suitable for single-cell analysis and especially live-cell imaging applications. Finally, we discuss prominent areas of need in future fluorescent tool development—specifically, advancing our capability to analyze and integrate the plethora of high-content data generated by fluorescence imaging.
Citations by journals
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Angewandte Chemie - International Edition
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Angewandte Chemie - International Edition
9 publications, 2.82%
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Angewandte Chemie
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Angewandte Chemie
9 publications, 2.82%
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Analytical Chemistry
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Analytical Chemistry
8 publications, 2.51%
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Communications Biology
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Communications Biology
6 publications, 1.88%
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Dyes and Pigments
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Dyes and Pigments
6 publications, 1.88%
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Methods in Molecular Biology
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Methods in Molecular Biology
6 publications, 1.88%
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Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
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Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
5 publications, 1.57%
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Chemistry - A European Journal
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Chemistry - A European Journal
5 publications, 1.57%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
4 publications, 1.25%
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Nanomaterials
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Nanomaterials
4 publications, 1.25%
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Scientific Reports
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Scientific Reports
4 publications, 1.25%
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Bioconjugate Chemistry
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Bioconjugate Chemistry
4 publications, 1.25%
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Journal of the American Chemical Society
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Journal of the American Chemical Society
4 publications, 1.25%
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Organic and Biomolecular Chemistry
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Organic and Biomolecular Chemistry
4 publications, 1.25%
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Biosensors and Bioelectronics
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Biosensors and Bioelectronics
3 publications, 0.94%
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iScience
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iScience
3 publications, 0.94%
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Chinese Chemical Letters
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Chinese Chemical Letters
3 publications, 0.94%
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Talanta
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Talanta
3 publications, 0.94%
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TrAC - Trends in Analytical Chemistry
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TrAC - Trends in Analytical Chemistry
3 publications, 0.94%
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Advanced Optical Materials
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Advanced Optical Materials
3 publications, 0.94%
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Biochemistry
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Biochemistry
3 publications, 0.94%
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Chemical Reviews
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Chemical Reviews
3 publications, 0.94%
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ACS Sensors
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ACS Sensors
3 publications, 0.94%
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ACS Applied Nano Materials
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ACS Applied Nano Materials
3 publications, 0.94%
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Biomedical Optics Express
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Biomedical Optics Express
3 publications, 0.94%
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Chemical Communications
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Chemical Communications
3 publications, 0.94%
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The Analyst
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The Analyst
3 publications, 0.94%
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RSC Advances
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RSC Advances
2 publications, 0.63%
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Molecules
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Molecules
2 publications, 0.63%
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Citations by publishers
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Elsevier
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Elsevier
63 publications, 19.75%
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Wiley
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Wiley
47 publications, 14.73%
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Springer Nature
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Springer Nature
43 publications, 13.48%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
39 publications, 12.23%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
24 publications, 7.52%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
21 publications, 6.58%
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Frontiers Media S.A.
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Frontiers Media S.A.
6 publications, 1.88%
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Optical Society of America
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Optical Society of America
4 publications, 1.25%
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American Institute of Physics (AIP)
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American Institute of Physics (AIP)
3 publications, 0.94%
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The Company of Biologists
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The Company of Biologists
3 publications, 0.94%
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IOP Publishing
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IOP Publishing
3 publications, 0.94%
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Annual Reviews
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Annual Reviews
3 publications, 0.94%
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American Physical Society (APS)
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American Physical Society (APS)
2 publications, 0.63%
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Biophysical Society
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Biophysical Society
2 publications, 0.63%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
2 publications, 0.63%
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Oxford University Press
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Oxford University Press
2 publications, 0.63%
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American Association for the Advancement of Science (AAAS)
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American Association for the Advancement of Science (AAAS)
2 publications, 0.63%
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Pirogov Russian National Research Medical University
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Pirogov Russian National Research Medical University
1 publication, 0.31%
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Beilstein-Institut
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Beilstein-Institut
1 publication, 0.31%
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Bentham Science
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Bentham Science
1 publication, 0.31%
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CSIRO Publishing
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CSIRO Publishing
1 publication, 0.31%
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S. Karger AG
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S. Karger AG
1 publication, 0.31%
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The Royal Society
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The Royal Society
1 publication, 0.31%
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Future Medicine
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Future Medicine
1 publication, 0.31%
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Future Science
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Future Science, 1, 0.31%
Future Science
1 publication, 0.31%
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The Electrochemical Society
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The Electrochemical Society
1 publication, 0.31%
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Nuclear Receptor Signaling Atlas
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Nuclear Receptor Signaling Atlas, 1, 0.31%
Nuclear Receptor Signaling Atlas
1 publication, 0.31%
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Taylor & Francis
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Taylor & Francis
1 publication, 0.31%
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Cambridge University Press
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Cambridge University Press
1 publication, 0.31%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.