Journal of Neurophysiology, volume 116, issue 1, pages 98-105

Integration of sensory, spinal, and volitional descending inputs in regulation of human locomotion.

Gerasimenko Yury 1, 2
Gad Parag 2
Mckinney Zach 3
Gorodnichev Ruslan 4
Puhov Aleksandr 4
Moshonkina Tatiana 1
Savochin Aleksandr 1
Selionov Victor 5
Kozlovskaya Inessa 6
Edgerton V. Reggie 2
2
 
Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California;
3
 
Department of Bioengineering, University of California, Los Angeles, Los Angeles, California;
4
 
Velikiye Luki State Academy of Physical Education and Sport, Velikiye Luki, Russia;
6
 
Russian Federation State Scientific Center-Institute for Bio-Medical Problems, Russian Academy of Sciences, Moscow, Russia
Publication typeJournal Article
Publication date2016-07-01
Quartile SCImago
Q1
Quartile WOS
Q3
Impact factor2.5
ISSN00223077, 15221598
General Neuroscience
Physiology
Abstract

We reported previously that both transcutaneous electrical spinal cord stimulation and direct pressure stimulation of the plantar surfaces of the feet can elicit rhythmic involuntary step-like movements in noninjured subjects with their legs in a gravity-neutral apparatus. The present experiments investigated the convergence of spinal and plantar pressure stimulation and voluntary effort in the activation of locomotor movements in uninjured subjects under full body weight support in a vertical position. For all conditions, leg movements were analyzed using electromyographic (EMG) recordings and optical motion capture of joint kinematics. Spinal cord stimulation elicited rhythmic hip and knee flexion movements accompanied by EMG bursting activity in the hamstrings of 6/6 subjects. Similarly, plantar stimulation induced bursting EMG activity in the ankle flexor and extensor muscles in 5/6 subjects. Moreover, the combination of spinal and plantar stimulation exhibited a synergistic effect in all six subjects, eliciting greater motor responses than either modality alone. While the motor responses to spinal vs. plantar stimulation seems to activate distinct but overlapping spinal neural networks, when engaged simultaneously, the stepping responses were functionally complementary. As observed during induced (involuntary) stepping, the most significant modulation of voluntary stepping occurred in response to the combination of spinal and plantar stimulation. In light of the known automaticity and plasticity of spinal networks in absence of supraspinal input, these findings support the hypothesis that spinal and plantar stimulation may be effective tools for enhancing the recovery of motor control in individuals with neurological injuries and disorders.

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Gerasimenko Y. et al. Integration of sensory, spinal, and volitional descending inputs in regulation of human locomotion. // Journal of Neurophysiology. 2016. Vol. 116. No. 1. pp. 98-105.
GOST all authors (up to 50) Copy
Gerasimenko Y., Gad P., Sayenko D., Mckinney Z., Gorodnichev R., Puhov A., Moshonkina T., Savochin A., Selionov V., Shigueva T., Tomilovskaya E., Kozlovskaya I., Edgerton V. R. Integration of sensory, spinal, and volitional descending inputs in regulation of human locomotion. // Journal of Neurophysiology. 2016. Vol. 116. No. 1. pp. 98-105.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1152/jn.00146.2016
UR - https://doi.org/10.1152%2Fjn.00146.2016
TI - Integration of sensory, spinal, and volitional descending inputs in regulation of human locomotion.
T2 - Journal of Neurophysiology
AU - Gerasimenko, Yury
AU - Gad, Parag
AU - Mckinney, Zach
AU - Gorodnichev, Ruslan
AU - Puhov, Aleksandr
AU - Moshonkina, Tatiana
AU - Savochin, Aleksandr
AU - Selionov, Victor
AU - Shigueva, Tatiana
AU - Kozlovskaya, Inessa
AU - Sayenko, Dimitry
AU - Edgerton, V. Reggie
AU - Tomilovskaya, Elena
PY - 2016
DA - 2016/07/01 00:00:00
PB - American Physiological Society
SP - 98-105
IS - 1
VL - 116
PMID - 27075538
SN - 0022-3077
SN - 1522-1598
ER -
BibTex |
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BibTex Copy
@article{2016_Gerasimenko
author = {Yury Gerasimenko and Parag Gad and Zach Mckinney and Ruslan Gorodnichev and Aleksandr Puhov and Tatiana Moshonkina and Aleksandr Savochin and Victor Selionov and Tatiana Shigueva and Inessa Kozlovskaya and Dimitry Sayenko and V. Reggie Edgerton and Elena Tomilovskaya},
title = {Integration of sensory, spinal, and volitional descending inputs in regulation of human locomotion.},
journal = {Journal of Neurophysiology},
year = {2016},
volume = {116},
publisher = {American Physiological Society},
month = {jul},
url = {https://doi.org/10.1152%2Fjn.00146.2016},
number = {1},
pages = {98--105},
doi = {10.1152/jn.00146.2016}
}
MLA
Cite this
MLA Copy
Gerasimenko, Yury, et al. “Integration of sensory, spinal, and volitional descending inputs in regulation of human locomotion..” Journal of Neurophysiology, vol. 116, no. 1, Jul. 2016, pp. 98-105. https://doi.org/10.1152%2Fjn.00146.2016.
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