Cancer Research, volume 79, issue 20, pages 5131-5139

Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma

Wong Samuel Y.S. ¹

Huang Feiyang ²

Lim Lee Jin ^{1, 3, 4}

Chong Samuel S. ⁵

Ooi London Lucien ^{6, 7}

Kon Oi Lian ¹

Lee Caroline ^{1, 3, 6, 8}

Hide authors affiliations Show authors affiliations: 8 affiliations

2Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, Singapore. |

3NUS High School of Math and Science, Singapore, Singapore. |

1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. |

⁴

4Raffles Institution, Singapore, Singapore. |

⁵

5Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. |

⁶

6Duke-NUS Graduate Medical School, Singapore, Singapore. |

⁷

7Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore. |

⁸

8NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore. |

Publication type: Journal Article

Publication date: 2019-10-15

American Association for Cancer Research (AACR)

Journal: Cancer Research

Quartile SCImago

Quartile WOS

Impact factor: 11.2

ISSN: 00085472, 15387445

DOI: 10.1158/0008-5472.CAN-19-0255

Copy DOI

Cancer Research

Oncology

Abstract

Next-generation sequencing has uncovered thousands of long noncoding RNAs (lncRNA). Many are reported to be aberrantly expressed in various cancers, including hepatocellular carcinoma (HCC), and play key roles in tumorigenesis. This review provides an in-depth discussion of the oncogenic mechanisms reported to be associated with deregulated HCC-associated lncRNAs. Transcriptional expression of lncRNAs in HCC is modulated through transcription factors, or epigenetically by aberrant histone acetylation or DNA methylation, and posttranscriptionally by lncRNA transcript stability modulated by miRNAs and RNA-binding proteins. Seventy-four deregulated lncRNAs have been identified in HCC, of which, 52 are upregulated. This review maps the oncogenic roles of these deregulated lncRNAs by integrating diverse datasets including clinicopathologic features, affected cancer phenotypes, associated miRNA and/or protein-interacting partners as well as modulated gene/protein expression. Notably, 63 deregulated lncRNAs are significantly associated with clinicopathologic features of HCC. Twenty-three deregulated lncRNAs associated with both tumor and metastatic clinical features were also tumorigenic and prometastatic in experimental models of HCC, and eight of these mapped to known cancer pathways. Fifty-two upregulated lncRNAs exhibit oncogenic properties and are associated with prominent hallmarks of cancer, whereas 22 downregulated lncRNAs have tumor-suppressive properties. Aberrantly expressed lncRNAs in HCC exert pleiotropic effects on miRNAs, mRNAs, and proteins. They affect multiple cancer phenotypes by altering miRNA and mRNA expression and stability, as well as through effects on protein expression, degradation, structure, or interactions with transcriptional regulators. Hence, these insights reveal novel lncRNAs as potential biomarkers and may enable the design of precision therapy for HCC.

By date By citations

Citations by journals

	1 2 3 4 5 6 7
Frontiers in Oncology	Frontiers in Oncology, 7, 5.22% Frontiers in Oncology 7 publications, 5.22%
Journal of Oncology	Journal of Oncology, 5, 3.73% Journal of Oncology 5 publications, 3.73%
Aging	Aging, 4, 2.99% Aging 4 publications, 2.99%
Oncology Letters	Oncology Letters, 3, 2.24% Oncology Letters 3 publications, 2.24%
Cancers	Cancers, 3, 2.24% Cancers 3 publications, 2.24%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 3, 2.24% Frontiers in Cell and Developmental Biology 3 publications, 2.24%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 3, 2.24% Biomedicine and Pharmacotherapy 3 publications, 2.24%
Journal of Cellular and Molecular Medicine	Journal of Cellular and Molecular Medicine, 3, 2.24% Journal of Cellular and Molecular Medicine 3 publications, 2.24%
Bioengineered	Bioengineered, 3, 2.24% Bioengineered 3 publications, 2.24%
Biomedicines	Biomedicines, 2, 1.49% Biomedicines 2 publications, 1.49%
Molecular Medicine Reports	Molecular Medicine Reports, 2, 1.49% Molecular Medicine Reports 2 publications, 1.49%
World Journal of Gastroenterology	World Journal of Gastroenterology, 2, 1.49% World Journal of Gastroenterology 2 publications, 1.49%
Frontiers in Genetics	Frontiers in Genetics, 2, 1.49% Frontiers in Genetics 2 publications, 1.49%
BMC Cancer	BMC Cancer, 2, 1.49% BMC Cancer 2 publications, 1.49%
Journal of Experimental and Clinical Cancer Research	Journal of Experimental and Clinical Cancer Research, 2, 1.49% Journal of Experimental and Clinical Cancer Research 2 publications, 1.49%
Human Cell	Human Cell, 2, 1.49% Human Cell 2 publications, 1.49%
Cell Death Discovery	Cell Death Discovery, 2, 1.49% Cell Death Discovery 2 publications, 1.49%
Archives of Medical Research	Archives of Medical Research, 2, 1.49% Archives of Medical Research 2 publications, 1.49%
Pathology Research and Practice	Pathology Research and Practice, 2, 1.49% Pathology Research and Practice 2 publications, 1.49%
Liver International	Liver International, 2, 1.49% Liver International 2 publications, 1.49%
Journal of Hepatocellular Carcinoma	Journal of Hepatocellular Carcinoma, 2, 1.49% Journal of Hepatocellular Carcinoma 2 publications, 1.49%
Disease Markers	Disease Markers, 2, 1.49% Disease Markers 2 publications, 1.49%
Heliyon	Heliyon, 2, 1.49% Heliyon 2 publications, 1.49%
Translational Cancer Research	Translational Cancer Research, 2, 1.49% Translational Cancer Research 2 publications, 1.49%
Journal of Cancer Research and Clinical Oncology	Journal of Cancer Research and Clinical Oncology, 1, 0.75% Journal of Cancer Research and Clinical Oncology 1 publication, 0.75%
Doklady Biochemistry and Biophysics	Doklady Biochemistry and Biophysics, 1, 0.75% Doklady Biochemistry and Biophysics 1 publication, 0.75%
Epigenomics	Epigenomics, 1, 0.75% Epigenomics 1 publication, 0.75%
Biomarkers in Medicine	Biomarkers in Medicine, 1, 0.75% Biomarkers in Medicine 1 publication, 0.75%
DNA and Cell Biology	DNA and Cell Biology, 1, 0.75% DNA and Cell Biology 1 publication, 0.75%
	1 2 3 4 5 6 7

Citations by publishers

	5 10 15 20 25
Springer Nature	Springer Nature, 22, 16.42% Springer Nature 22 publications, 16.42%
Elsevier	Elsevier, 22, 16.42% Elsevier 22 publications, 16.42%
Frontiers Media S.A.	Frontiers Media S.A., 18, 13.43% Frontiers Media S.A. 18 publications, 13.43%
Hindawi Limited	Hindawi Limited, 14, 10.45% Hindawi Limited 14 publications, 10.45%
Wiley	Wiley, 13, 9.7% Wiley 13 publications, 9.7%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 7, 5.22% Multidisciplinary Digital Publishing Institute (MDPI) 7 publications, 5.22%
Spandidos Publications	Spandidos Publications, 7, 5.22% Spandidos Publications 7 publications, 5.22%
Impact Journals	Impact Journals, 4, 2.99% Impact Journals 4 publications, 2.99%
Baishideng Publishing Group	Baishideng Publishing Group, 4, 2.99% Baishideng Publishing Group 4 publications, 2.99%
Taylor & Francis	Taylor & Francis, 4, 2.99% Taylor & Francis 4 publications, 2.99%
AME Publishing Company	AME Publishing Company, 4, 2.99% AME Publishing Company 4 publications, 2.99%
Future Medicine	Future Medicine, 3, 2.24% Future Medicine 3 publications, 2.24%
Dove Medical Press	Dove Medical Press, 3, 2.24% Dove Medical Press 3 publications, 2.24%
Pleiades Publishing	Pleiades Publishing, 1, 0.75% Pleiades Publishing 1 publication, 0.75%
Mary Ann Liebert	Mary Ann Liebert, 1, 0.75% Mary Ann Liebert 1 publication, 0.75%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 0.75% Public Library of Science (PLoS) 1 publication, 0.75%
Federation of American Societies for Experimental Biology (FASEB)	Federation of American Societies for Experimental Biology (FASEB), 1, 0.75% Federation of American Societies for Experimental Biology (FASEB) 1 publication, 0.75%
Walter de Gruyter	Walter de Gruyter, 1, 0.75% Walter de Gruyter 1 publication, 0.75%
Oxford University Press	Oxford University Press, 1, 0.75% Oxford University Press 1 publication, 0.75%
Begell House	Begell House, 1, 0.75% Begell House 1 publication, 0.75%
	5 10 15 20 25

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GOST Copy

Wong S. Y. et al. Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma // Cancer Research. 2019. Vol. 79. No. 20. pp. 5131-5139.

GOST all authors (up to 50) Copy

Wong S. Y., Huang F., Lim L. J., Chong S. S., Ooi L. L., Kon O. L., Lee C. Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma // Cancer Research. 2019. Vol. 79. No. 20. pp. 5131-5139.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1158/0008-5472.CAN-19-0255

UR - https://doi.org/10.1158%2F0008-5472.CAN-19-0255

TI - Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma

T2 - Cancer Research

AU - Lim, Lee Jin

AU - Wong, Samuel Y.S.

AU - Huang, Feiyang

AU - Chong, Samuel S.

AU - Ooi, London Lucien

AU - Kon, Oi Lian

AU - Lee, Caroline

PY - 2019

DA - 2019/10/15 00:00:00

PB - American Association for Cancer Research (AACR)

SP - 5131-5139

IS - 20

VL - 79

SN - 0008-5472

SN - 1538-7445

ER -

BibTex |

Cite this

BibTex Copy

@article{2019_Wong,

author = {Lee Jin Lim and Samuel Y.S. Wong and Feiyang Huang and Samuel S. Chong and London Lucien Ooi and Oi Lian Kon and Caroline Lee},

title = {Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma},

journal = {Cancer Research},

year = {2019},

volume = {79},

publisher = {American Association for Cancer Research (AACR)},

month = {oct},

url = {https://doi.org/10.1158%2F0008-5472.CAN-19-0255},

number = {20},

pages = {5131--5139},

doi = {10.1158/0008-5472.CAN-19-0255}

}

MLA

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MLA Copy

Wong, Samuel Y.S., et al. “Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma.” Cancer Research, vol. 79, no. 20, Oct. 2019, pp. 5131-5139. https://doi.org/10.1158%2F0008-5472.CAN-19-0255.

Found error?

Publisher

American Association for Cancer Research (AACR)

Journal

Cancer Research

Quartile SCImago

Quartile WOS

Impact factor

11.2

ISSN

00085472 (Print)
15387445 (Electronic)

Profiles

Lee, Caroline G