Open Access
Genome Biology, volume 15, issue 1, pages R6
Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes
van Heesch Sebastiaan
1
,
van Iterson Maarten
1
,
Jacobi Jetse
1
,
Boymans Sander
1
,
Essers Paul B.
2
,
De Bruijn Ewart
1
,
Hao Wensi
1
,
Macinnes Alyson W
2
,
Cuppen Edwin
1, 3
,
Simonis Marieke
1
1
Genome Biology Group, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
|
2
Ribosome Biogenesis and Disease Group, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
|
3
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
|
Publication type: Journal Article
Publication date: 2014-01-07
Journal:
Genome Biology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 12.3
ISSN: 14747596, 14656906, 1474760X
PubMed ID:
24393600
General Medicine
Abstract
BackgroundLong noncoding RNAs (lncRNAs) form an abundant class of transcripts, but the function of the majority of them remains elusive. While it has been shown that some lncRNAs are bound by ribosomes, it has also been convincingly demonstrated that these transcripts do not code for proteins. To obtain a comprehensive understanding of the extent to which lncRNAs bind ribosomes, we performed systematic RNA sequencing on ribosome-associated RNA pools obtained through ribosomal fractionation and compared the RNA content with nuclear and (non-ribosome bound) cytosolic RNA pools.ResultsThe RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1.ConclusionsMost studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes.
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van Heesch S. et al. Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes // Genome Biology. 2014. Vol. 15. No. 1. p. R6.
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van Heesch S., van Iterson M., Jacobi J., Boymans S., Essers P. B., De Bruijn E., Hao W., Macinnes A. W., Cuppen E., Simonis M. Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes // Genome Biology. 2014. Vol. 15. No. 1. p. R6.
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TY - JOUR
DO - 10.1186/gb-2014-15-1-r6
UR - https://doi.org/10.1186%2Fgb-2014-15-1-r6
TI - Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes
T2 - Genome Biology
AU - van Heesch, Sebastiaan
AU - van Iterson, Maarten
AU - Jacobi, Jetse
AU - Boymans, Sander
AU - Essers, Paul B.
AU - De Bruijn, Ewart
AU - Hao, Wensi
AU - Macinnes, Alyson W
AU - Cuppen, Edwin
AU - Simonis, Marieke
PY - 2014
DA - 2014/01/07 00:00:00
PB - Springer Nature
SP - R6
IS - 1
VL - 15
PMID - 24393600
SN - 1474-7596
SN - 1465-6906
SN - 1474-760X
ER -
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@article{2014_van Heesch,
author = {Sebastiaan van Heesch and Maarten van Iterson and Jetse Jacobi and Sander Boymans and Paul B. Essers and Ewart De Bruijn and Wensi Hao and Alyson W Macinnes and Edwin Cuppen and Marieke Simonis},
title = {Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes},
journal = {Genome Biology},
year = {2014},
volume = {15},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1186%2Fgb-2014-15-1-r6},
number = {1},
pages = {R6},
doi = {10.1186/gb-2014-15-1-r6}
}
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van Heesch, Sebastiaan, et al. “Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes.” Genome Biology, vol. 15, no. 1, Jan. 2014, p. R6. https://doi.org/10.1186%2Fgb-2014-15-1-r6.