Open Access
Molecular Cancer, volume 16, issue 1, publication number 79
ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
Publication type: Journal Article
Publication date: 2017-04-13
PubMed ID:
28407774
Cancer Research
Oncology
Molecular Medicine
Abstract
Cancer cells are frequently confronted with metabolic stress in tumor microenvironments due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death through ROS-induced apoptosis. However, cancer cells can adapt to it by altering the metabolic pathways. AMPK and AKT are two primary effectors in response to metabolic stress: AMPK acts as an energy-sensing factor which rewires metabolism and maintains redox balance. AKT broadly promotes energy production in the nutrient abundance milieu, but the role of AKT under metabolic stress is in dispute. Recent studies show that AMPK and AKT display antagonistic roles under metabolic stress. Metabolic stress-induced ROS signaling lies in the hub between metabolic reprogramming and redox homeostasis. Here, we highlight the cross-talk between AMPK and AKT and their regulation on ROS production and elimination, which summarizes the mechanism of cancer cell adaptability under ROS stress and suggests potential options for cancer therapeutics.
Citations by journals
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International Journal of Molecular Sciences
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4 publications, 0.94%
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PLoS ONE
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3 publications, 0.7%
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3 publications, 0.7%
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Citations by publishers
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Elsevier
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Elsevier
89 publications, 20.89%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Springer Nature
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71 publications, 16.67%
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Frontiers Media S.A.
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Wiley
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Hindawi Limited
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Taylor & Francis
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Taylor & Francis
12 publications, 2.82%
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American Chemical Society (ACS)
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Mary Ann Liebert
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Mary Ann Liebert
5 publications, 1.17%
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Spandidos Publications
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4 publications, 0.94%
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Oxford University Press
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Oxford University Press
4 publications, 0.94%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
4 publications, 0.94%
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SAGE
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SAGE
3 publications, 0.7%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
3 publications, 0.7%
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Bioscientifica
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3 publications, 0.7%
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2 publications, 0.47%
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2 publications, 0.47%
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IOS Press
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S. Karger AG
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AME Publishing Company
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American Society for Clinical Investigation
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The Company of Biologists
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Pharmaceutical Society of Korea
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1 publication, 0.23%
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Federation of American Societies for Experimental Biology (FASEB)
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1 publication, 0.23%
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Dove Medical Press
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Dove Medical Press
1 publication, 0.23%
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Thieme
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Thieme
1 publication, 0.23%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Zhao Y. et al. ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway // Molecular Cancer. 2017. Vol. 16. No. 1. 79
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Zhao Y., HU X., Liu Y., Dong S., Wen Z., He W., Zhang S., Huang Q., Shi M. ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway // Molecular Cancer. 2017. Vol. 16. No. 1. 79
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TY - JOUR
DO - 10.1186/s12943-017-0648-1
UR - https://doi.org/10.1186%2Fs12943-017-0648-1
TI - ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
T2 - Molecular Cancer
AU - Zhao, Yang
AU - HU, XINGBIN
AU - Liu, Yajing
AU - Dong, Shumin
AU - Wen, Zhaowei
AU - He, Wanming
AU - Zhang, Shuyi
AU - Huang, Qiong
AU - Shi, Min
PY - 2017
DA - 2017/04/13 00:00:00
PB - Springer Nature
IS - 1
VL - 16
PMID - 28407774
SN - 1476-4598
ER -
Cite this
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@article{2017_Zhao,
author = {Yang Zhao and XINGBIN HU and Yajing Liu and Shumin Dong and Zhaowei Wen and Wanming He and Shuyi Zhang and Qiong Huang and Min Shi},
title = {ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway},
journal = {Molecular Cancer},
year = {2017},
volume = {16},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1186%2Fs12943-017-0648-1},
number = {1},
doi = {10.1186/s12943-017-0648-1}
}