Global Epidemiology, Prevention, and Management of Hepatocellular Carcinoma
The incidence rate of hepatocellular carcinoma (HCC) is rising. It is one of the most common cancers worldwide and accounts for substantial morbidity and mortality. Chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, and nonalcoholic fatty liver disease (NAFLD) are the most important etiologies of HCC, and effective screening and management strategies are crucial to reduce the HCC risk. For HBV, which accounts for the majority of HCC cases, most infections were acquired via perinatal and early horizontal transmission. Universal vaccination of newborns has led to a decline in HCC incidence compared with the pre-vaccination era. Effective antiviral therapies with nucleos(t)ide analogues or pegylated interferon reduced the incidence of HCC. For HCV, the emergence of effective direct-acting antiviral (DAA) agents has substantially improved cure rates; therefore all patients with HCV should be considered for DAA treatment. The most important obstacle in eliminating HCV is access to therapy. For NAFLD, the global incidence is increasing rapidly, thus its impact on HCC incidence may be explosive. Progression to HCC in NAFLD happens particularly in those with nonalcoholic steatohepatitis (NASH) and exacerbated by metabolic syndrome, or PNPLA3 gene polymorphism. Lifestyle changes are imperative while drug therapy has yet to demonstrate substantive protective effects on HCC prevention. For management of HCC, early diagnosis via imaging surveillance among persons with HCC risk factors remains the most important strategy to identify early-stage disease appropriate for resection or transplantation.
Citations by journals
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Cancers
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Cancers
5 publications, 3.5%
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Frontiers in Oncology
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Frontiers in Oncology
4 publications, 2.8%
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Frontiers in Pharmacology
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Frontiers in Pharmacology
4 publications, 2.8%
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Molecules
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Molecules
3 publications, 2.1%
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Scientific Reports
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Scientific Reports
3 publications, 2.1%
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Future Oncology
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Future Oncology
2 publications, 1.4%
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Experimental and Therapeutic Medicine
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Experimental and Therapeutic Medicine
2 publications, 1.4%
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International Journal of Oncology
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International Journal of Oncology
2 publications, 1.4%
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Medicine (United States)
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Medicine (United States)
2 publications, 1.4%
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World Chinese Journal of Digestology
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World Chinese Journal of Digestology, 2, 1.4%
World Chinese Journal of Digestology
2 publications, 1.4%
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Hepatology International
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Hepatology International
2 publications, 1.4%
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Human Cell
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Human Cell
2 publications, 1.4%
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Cancer Management and Research
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Cancer Management and Research
2 publications, 1.4%
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Journal of Hepatocellular Carcinoma
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Journal of Hepatocellular Carcinoma
2 publications, 1.4%
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Annals of Translational Medicine
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Annals of Translational Medicine
2 publications, 1.4%
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Journal of Cancer Research and Clinical Oncology
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Journal of Cancer Research and Clinical Oncology
1 publication, 0.7%
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Doklady Biochemistry and Biophysics
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Doklady Biochemistry and Biophysics
1 publication, 0.7%
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Frontiers in Public Health
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Frontiers in Public Health
1 publication, 0.7%
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Open Biomarkers Journal
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Open Biomarkers Journal
1 publication, 0.7%
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Anti-Cancer Agents in Medicinal Chemistry
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Anti-Cancer Agents in Medicinal Chemistry
1 publication, 0.7%
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Liver Cancer
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Liver Cancer
1 publication, 0.7%
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Bioscience Reports
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Bioscience Reports
1 publication, 0.7%
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Hepatology Communications
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Hepatology Communications
1 publication, 0.7%
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Nursing
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Nursing
1 publication, 0.7%
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Hepatology
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Hepatology
1 publication, 0.7%
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Chinese Medical Journal
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Chinese Medical Journal
1 publication, 0.7%
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American Journal of Surgical Pathology
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American Journal of Surgical Pathology
1 publication, 0.7%
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World Journal of Clinical Cases
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World Journal of Clinical Cases
1 publication, 0.7%
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World Journal of Gastroenterology
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World Journal of Gastroenterology
1 publication, 0.7%
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Citations by publishers
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30
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Springer Nature
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Springer Nature
26 publications, 18.18%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
15 publications, 10.49%
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Frontiers Media S.A.
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Frontiers Media S.A.
14 publications, 9.79%
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Wiley
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Wiley
12 publications, 8.39%
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Elsevier
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Elsevier
12 publications, 8.39%
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Wolters Kluwer Health
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Wolters Kluwer Health
6 publications, 4.2%
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AME Publishing Company
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AME Publishing Company
5 publications, 3.5%
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Spandidos Publications
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Spandidos Publications
4 publications, 2.8%
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Dove Medical Press
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Dove Medical Press
4 publications, 2.8%
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Baishideng Publishing Group
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Baishideng Publishing Group
3 publications, 2.1%
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Taylor & Francis
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Taylor & Francis
3 publications, 2.1%
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Hindawi Limited
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Hindawi Limited
3 publications, 2.1%
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Pleiades Publishing
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Pleiades Publishing
2 publications, 1.4%
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Bentham Science
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Bentham Science
2 publications, 1.4%
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Future Medicine
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Future Medicine
2 publications, 1.4%
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S. Karger AG
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S. Karger AG
2 publications, 1.4%
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Shi Jie Wei Chang Bing Xue Za Zhi She
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Shi Jie Wei Chang Bing Xue Za Zhi She, 2, 1.4%
Shi Jie Wei Chang Bing Xue Za Zhi She
2 publications, 1.4%
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SAGE
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SAGE
2 publications, 1.4%
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Thieme
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Thieme
2 publications, 1.4%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
1 publication, 0.7%
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Oxford University Press
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Oxford University Press
1 publication, 0.7%
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Ob'edinennaya Redakcya OOO
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Ob'edinennaya Redakcya OOO, 1, 0.7%
Ob'edinennaya Redakcya OOO
1 publication, 0.7%
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Yonsei University
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Yonsei University, 1, 0.7%
Yonsei University
1 publication, 0.7%
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Media Sphere Publishing Group
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Media Sphere Publishing Group
1 publication, 0.7%
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Turk Biyokimya Dernegi
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Turk Biyokimya Dernegi, 1, 0.7%
Turk Biyokimya Dernegi
1 publication, 0.7%
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Scientific Centre for Family Health and Human Reproduction Problems
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Scientific Centre for Family Health and Human Reproduction Problems
1 publication, 0.7%
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Grodno State Medical University
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Grodno State Medical University
1 publication, 0.7%
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Jaypee Brothers Medical Publishing
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Jaypee Brothers Medical Publishing, 1, 0.7%
Jaypee Brothers Medical Publishing
1 publication, 0.7%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.