Open Access
RNA, volume 19, issue 11, pages 1563-1574
Specific features of telomerase RNA from Hansenula polymorpha
Smekalova Elena M
1
,
Dontsova Olga A.
1
,
Zvereva Maria I.
,
Ravin N. V.
2
,
Mardanov Andrey V.
,
Skryabin Konstantin G.
2
,
Westhof Eric
,
Zvereva Maria
1
,
Mardanov A. V.
2
,
Westhof Eric
3
2
3Centre Bioengineering of RAS, Moscow 117312, Russia
|
Publication type: Journal Article
Publication date: 2013-09-17
PubMed ID:
24046481
Molecular Biology
Abstract
Telomerase, a ribonucleoprotein, is responsible for the maintenance of eukaryotic genome integrity by replicating the ends of chromosomes. The core enzyme comprises the conserved protein TERT and an RNA subunit (TER) that, in contrast, displays large variations in size and structure. Here, we report the identification of the telomerase RNA from thermotolerant yeast Hansenula polymorpha (HpTER) and describe its structural features. We show further that the H. polymorpha telomerase reverse transcribes the template beyond the predicted boundary and adds a nontelomeric dT in vitro. Sequencing of the chromosomal ends revealed that this nucleotide is specifically present as a terminal nucleotide at the 3′ end of telomeres. Mutational analysis of HpTER confirmed that the incorporation of dT functions to limit telomere length in this species.
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2 publications, 14.29%
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1 publication, 7.14%
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1 publication, 7.14%
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1 publication, 7.14%
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eLife
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eLife
1 publication, 7.14%
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1 publication, 7.14%
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1 publication, 7.14%
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1 publication, 7.14%
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Citations by publishers
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Springer Nature
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5 publications, 35.71%
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2 publications, 14.29%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 14.29%
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Oxford University Press
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Oxford University Press
1 publication, 7.14%
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Wiley
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Wiley
1 publication, 7.14%
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eLife Sciences Publications
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eLife Sciences Publications
1 publication, 7.14%
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1
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5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Smekalova E. M. et al. Specific features of telomerase RNA from Hansenula polymorpha // RNA. 2013. Vol. 19. No. 11. pp. 1563-1574.
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Smekalova E. M., Malyavko A. N., Zvereva M. I., Mardanov A. V., Ravin N. V., Skryabin K. G., Westhof E., Dontsova O. A., Zvereva M., Mardanov A. V., Westhof E. Specific features of telomerase RNA from Hansenula polymorpha // RNA. 2013. Vol. 19. No. 11. pp. 1563-1574.
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TY - JOUR
DO - 10.1261/RNA.038612.113
UR - https://doi.org/10.1261%2FRNA.038612.113
TI - Specific features of telomerase RNA from Hansenula polymorpha
T2 - RNA
AU - Smekalova, Elena M
AU - Malyavko, Alexander N
AU - Zvereva, Maria I.
AU - Mardanov, Andrey V.
AU - Ravin, N. V.
AU - Skryabin, Konstantin G.
AU - Westhof, Eric
AU - Dontsova, Olga A.
AU - Zvereva, Maria
AU - Mardanov, A. V.
AU - Westhof, Eric
PY - 2013
DA - 2013/09/17 00:00:00
PB - Cold Spring Harbor Laboratory
SP - 1563-1574
IS - 11
VL - 19
PMID - 24046481
SN - 1355-8382
SN - 1469-9001
ER -
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@article{2013_Smekalova,
author = {Elena M Smekalova and Alexander N Malyavko and Maria I. Zvereva and Andrey V. Mardanov and N. V. Ravin and Konstantin G. Skryabin and Eric Westhof and Olga A. Dontsova and Maria Zvereva and A. V. Mardanov and Eric Westhof},
title = {Specific features of telomerase RNA from Hansenula polymorpha},
journal = {RNA},
year = {2013},
volume = {19},
publisher = {Cold Spring Harbor Laboratory},
month = {sep},
url = {https://doi.org/10.1261%2FRNA.038612.113},
number = {11},
pages = {1563--1574},
doi = {10.1261/RNA.038612.113}
}
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MLA
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Smekalova, Elena M., et al. “Specific features of telomerase RNA from Hansenula polymorpha.” RNA, vol. 19, no. 11, Sep. 2013, pp. 1563-1574. https://doi.org/10.1261%2FRNA.038612.113.