RNA, volume 27, issue 3, pages 265-272
Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation.
Publication type: Journal Article
Publication date: 2020-12-01
PubMed ID:
33262249
Molecular Biology
Abstract
We have recently reported on an experimental model of mitochondrial mistranslation conferred by amino acid exchange V338Y in the mitochondrial ribosomal protein MrpS5. Here we used a combination of RNA-Seq and metabolic profiling of homozygous transgenic MrpS5V338Y/V338Y mice to analyze the changes associated with the V338Y mutation in post-mitotic skeletal muscle. Metabolic profiling demonstrated age-dependent metabolic changes in the mutant V338Y animals, which included enhanced levels of age-associated metabolites and which were accompanied by increased glycolysis, lipid desaturation and eicosanoid biosynthesis, and alterations of the pentose phosphate pathway. In addition, transcriptome signatures of aged V338Y mutant muscle pointed to elevated inflammation, likely reflecting the increased levels of bioactive lipids. Our findings indicate that mistranslation-mediated chronic impairment of mitochondrial function affects specific bioenergetic processes in muscle in an age-dependent manner.
Citations by journals
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International Journal of Molecular Sciences
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4 publications, 40%
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
5 publications, 50%
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Frontiers Media S.A.
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2 publications, 20%
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Springer Nature
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Springer Nature
1 publication, 10%
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Elsevier
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Elsevier
1 publication, 10%
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Wolters Kluwer Health
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Wolters Kluwer Health
1 publication, 10%
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Shcherbakov D. et al. Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation. // RNA. 2020. Vol. 27. No. 3. pp. 265-272.
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Shcherbakov D., Duscha S., Juskeviciene R., Restelli L. M., Frank S., Laczko E., Böttger E. C. Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation. // RNA. 2020. Vol. 27. No. 3. pp. 265-272.
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TY - JOUR
DO - 10.1261/rna.077347.120
UR - https://doi.org/10.1261%2Frna.077347.120
TI - Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation.
T2 - RNA
AU - Shcherbakov, Dimitri
AU - Duscha, Stefan
AU - Juskeviciene, Reda
AU - Restelli, Lisa M
AU - Frank, Stephan
AU - Laczko, Endre
AU - Böttger, Erik C.
PY - 2020
DA - 2020/12/01 00:00:00
PB - Cold Spring Harbor Laboratory
SP - 265-272
IS - 3
VL - 27
PMID - 33262249
SN - 1355-8382
SN - 1469-9001
ER -
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@article{2020_Shcherbakov,
author = {Dimitri Shcherbakov and Stefan Duscha and Reda Juskeviciene and Lisa M Restelli and Stephan Frank and Endre Laczko and Erik C. Böttger},
title = {Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation.},
journal = {RNA},
year = {2020},
volume = {27},
publisher = {Cold Spring Harbor Laboratory},
month = {dec},
url = {https://doi.org/10.1261%2Frna.077347.120},
number = {3},
pages = {265--272},
doi = {10.1261/rna.077347.120}
}
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MLA
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Shcherbakov, Dimitri, et al. “Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation..” RNA, vol. 27, no. 3, Dec. 2020, pp. 265-272. https://doi.org/10.1261%2Frna.077347.120.