Open Access
PLoS Genetics, volume 8, issue 6, pages e1002747
TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends
Publication type: Journal Article
Publication date: 2012-06-14
Journal:
PLoS Genetics
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 4.5
ISSN: 15537390, 15537404
PubMed ID:
22719262
Cancer Research
Molecular Biology
Genetics
Ecology, Evolution, Behavior and Systematics
Genetics (clinical)
Abstract
The long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency, centromeric instability, facial anomalies) patients correlates with short telomeres. To study the mechanism of telomere length control by TERRA in Saccharomyces cerevisiae, we mapped the transcriptional start site of TERRA at telomere 1L and inserted a doxycycline regulatable promoter upstream. Induction of TERRA transcription led to telomere shortening of 1L but not of other chromosome ends. TERRA interacts with the Exo1-inhibiting Ku70/80 complex, and deletion of EXO1 but not MRE11 fully suppressed the TERRA–mediated short telomere phenotype in presence and absence of telomerase. Thus TERRA transcription facilitates the 5′-3′ nuclease activity of Exo1 at chromosome ends, providing a means to regulate the telomere shortening rate. Thereby, telomere transcription can regulate cellular lifespan through modulation of chromosome end processing activities.
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Citations by publishers
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Pfeiffer V., Lingner J. TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends // PLoS Genetics. 2012. Vol. 8. No. 6. p. e1002747.
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Pfeiffer V., Lingner J. TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends // PLoS Genetics. 2012. Vol. 8. No. 6. p. e1002747.
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TY - JOUR
DO - 10.1371/journal.pgen.1002747
UR - https://doi.org/10.1371%2Fjournal.pgen.1002747
TI - TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends
T2 - PLoS Genetics
AU - Pfeiffer, Verena
AU - Lingner, Joachim
PY - 2012
DA - 2012/06/14 00:00:00
PB - Public Library of Science (PLoS)
SP - e1002747
IS - 6
VL - 8
PMID - 22719262
SN - 1553-7390
SN - 1553-7404
ER -
Cite this
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@article{2012_Pfeiffer,
author = {Verena Pfeiffer and Joachim Lingner},
title = {TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends},
journal = {PLoS Genetics},
year = {2012},
volume = {8},
publisher = {Public Library of Science (PLoS)},
month = {jun},
url = {https://doi.org/10.1371%2Fjournal.pgen.1002747},
number = {6},
pages = {e1002747},
doi = {10.1371/journal.pgen.1002747}
}
Cite this
MLA
Copy
Pfeiffer, Verena, and Joachim Lingner. “TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends.” PLoS Genetics, vol. 8, no. 6, Jun. 2012, p. e1002747. https://doi.org/10.1371%2Fjournal.pgen.1002747.