Open Access
PLoS Genetics, volume 9, issue 1, pages e1003214
Telomerase Is Required for Zebrafish Lifespan
Henriques Catarina M
1
,
Carneiro Madalena C.
1
,
Tenente Inês M
2
,
Jacinto António
3
,
Ferreira Miguel Godinho
1
1
Instituto Gulbenkian De Ciência, Oeiras, Portugal
|
2
Instituto Gulbenkian de Ciência, Oeiras, Portugal,
|
3
Instituto de Medicina Molecular, Lisbon, Portugal,
|
Publication type: Journal Article
Publication date: 2013-01-17
Journal:
PLoS Genetics
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 4.5
ISSN: 15537390, 15537404
PubMed ID:
23349637
Cancer Research
Molecular Biology
Genetics
Ecology, Evolution, Behavior and Systematics
Genetics (clinical)
Abstract
Telomerase activity is restricted in humans. Consequentially, telomeres shorten in most cells throughout our lives. Telomere dysfunction in vertebrates has been primarily studied in inbred mice strains with very long telomeres that fail to deplete telomeric repeats during their lifetime. It is, therefore, unclear how telomere shortening regulates tissue homeostasis in vertebrates with naturally short telomeres. Zebrafish have restricted telomerase expression and human-like telomere length. Here we show that first-generation tert−/− zebrafish die prematurely with shorter telomeres. tert−/− fish develop degenerative phenotypes, including premature infertility, gastrointestinal atrophy, and sarcopaenia. tert−/− mutants have impaired cell proliferation, accumulation of DNA damage markers, and a p53 response leading to early apoptosis, followed by accumulation of senescent cells. Apoptosis is primarily observed in the proliferative niche and germ cells. Cell proliferation, but not apoptosis, is rescued in tp53−/−tert−/− mutants, underscoring p53 as mediator of telomerase deficiency and consequent telomere instability. Thus, telomerase is limiting for zebrafish lifespan, enabling the study of telomere shortening in naturally ageing individuals.
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1 publication, 1.03%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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BibTex |
MLA
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GOST
Copy
Henriques C. M. et al. Telomerase Is Required for Zebrafish Lifespan // PLoS Genetics. 2013. Vol. 9. No. 1. p. e1003214.
GOST all authors (up to 50)
Copy
Henriques C. M., Carneiro M. C., Tenente I. M., Jacinto A., Ferreira M. G. Telomerase Is Required for Zebrafish Lifespan // PLoS Genetics. 2013. Vol. 9. No. 1. p. e1003214.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1371/journal.pgen.1003214
UR - https://doi.org/10.1371%2Fjournal.pgen.1003214
TI - Telomerase Is Required for Zebrafish Lifespan
T2 - PLoS Genetics
AU - Henriques, Catarina M
AU - Carneiro, Madalena C.
AU - Tenente, Inês M
AU - Jacinto, António
AU - Ferreira, Miguel Godinho
PY - 2013
DA - 2013/01/17 00:00:00
PB - Public Library of Science (PLoS)
SP - e1003214
IS - 1
VL - 9
PMID - 23349637
SN - 1553-7390
SN - 1553-7404
ER -
Cite this
BibTex
Copy
@article{2013_Henriques,
author = {Catarina M Henriques and Madalena C. Carneiro and Inês M Tenente and António Jacinto and Miguel Godinho Ferreira},
title = {Telomerase Is Required for Zebrafish Lifespan},
journal = {PLoS Genetics},
year = {2013},
volume = {9},
publisher = {Public Library of Science (PLoS)},
month = {jan},
url = {https://doi.org/10.1371%2Fjournal.pgen.1003214},
number = {1},
pages = {e1003214},
doi = {10.1371/journal.pgen.1003214}
}
Cite this
MLA
Copy
Henriques, Catarina M., et al. “Telomerase Is Required for Zebrafish Lifespan.” PLoS Genetics, vol. 9, no. 1, Jan. 2013, p. e1003214. https://doi.org/10.1371%2Fjournal.pgen.1003214.